• Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice 

      Svärd, Jessica; Røst, Therese Halvorsen; Sommervoll, Camilla Elise Nergård; Haugen, Christine; Gudbrandsen, Oddrun Anita; Christensen, Anne Elisabeth; Rødahl, Eyvind; Fernø, Johan; Dankel, Simon N; Sagen, Jørn V.; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)
      Studies have implicated the extracellular matrix (ECM) of adipose tissue in insulin resistance. The proteoglycan decorin, a component of ECM, has been associated with glucose tolerance, but possible causal effects on ...
    • The Active Tamoxifen Metabolite Endoxifen (4OHNDtam) Strongly Down-Regulates Cytokeratin 6 (CK6) in MCF-7 Breast Cancer Cells 

      Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N; Fenne, Ingvild Sveinsgjerd; Skartveit, Linn; Drangevåg, Andreas; Bozickovic, Olivera; Flågeng, Marianne Hauglid; Søiland, Håvard; Mellgren, Gunnar; Lien, Ernst Asbjørn (Peer reviewed; Journal article, 2015-04-13)
      Introduction: Tamoxifen is an anti-estrogen drug used in treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sumof tamoxifen and all itsmetabolites. 4-Hydroxytamoxifen ...
    • COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1 

      Dankel, Simon N; Grytten, Elise; Bjune, Jan-Inge; Nielsen, Hans Jørgen; Dietrich, Arne; Blüher, Matthias; Sagen, Jørn V.; Mellgren, Gunnar (Journal article; Peer reviewed, 2020)
      Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a ...
    • A MicroRNA Linking Human Positive Selection and Metabolic Disorders 

      Wang, Lifeng; Sinnott-Armstrong, Nicholas A; Wagschal, Alexandre; Wark, Abigail R.; Camporez, Joao-Paulo; Perry, Rachel J.; Ji, Fei; Sohn, Yoojin; Oh, Justin; Wu, Su; Chery, Jessica; Moud, Bahareh Nemati; Saadat, Alham; Dankel, Simon N; Mellgren, Gunnar; Tallapragada, Divya Sri Priyanka; Strobel, Sophie Madlen; Lee, Mi-Jeong; Tewhey, Ryan; Sabeti, Pardis C.; Schaefer, Anne; Petri, Andreas; Kauppinen, Sakari; Chung, Raymond T.; Soukas, Alexander; Avruch, Joseph; Fried, Susan K.; Hauner, Hans; Sadreyev, Ruslan I.; Shulman, Gerald I.; Claussnitzer, Melina; Näär, Anders M. (Journal article; Peer reviewed, 2020)
      Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also ...
    • Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats 

      Nilsen, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon N; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)
      Objective Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ...
    • Primary Hyperparathyroidism Influences the Expression of Inflammatory and Metabolic Genes in Adipose Tissue 

      Christensen, Monika H. E.; Dankel, Simon N; Nordbø, Yngve; Varhaug, Jan Erik; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar (Peer reviewed; Journal article, 2011-06-17)
      Background: Primary hyperparathyroidism (PHPT) is characterised by increased production of parathyroid hormone (PTH) resulting in elevated serum calcium levels. The influence on bone metabolism with altered bone resorption ...
    • The Rho GTPase RND3 regulates adipocyte lipolysis 

      Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné; Fandalyuk, Zinayida; Skurk, Thomas; Hauner, Hans; Sagen, Jørn V.; Rydén, Mikael; Arner, Peter; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)
      Background: Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyte ...
    • Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance 

      Jersin, Regine Å.; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona S.; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)
      Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ...
    • Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis 

      Gudbrandsen, Oddrun Anita; Dankel, Simon N; Skumsnes, Lillian; Flølo, Tone Nygaard; Folkestad, Oddry H; Nielsen, Hans Jørgen; Våge, Villy; Mohn, Arne-Christian; Nedrebø, Bjørn Gunnar; Sagen, Jørn V.; Fernø, Johan; Mellgren, Gunnar (Peer reviewed; Journal article, 2019-10-15)
      The objective of this study was to compare the biochemical changes related to glucose tolerance and lipid metabolism in non-diabetic patients shortly after vertical sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). ...
    • Switch from stress response to homeobox transcription factors in Adipose tissue after profound fat loss 

      Dankel, Simon N; Fadnes, Dag J.; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen Thi Van; Veum, Vivian L.; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar (Peer reviewed; Journal article, 2010-06-09)
      Background In obesity, impaired adipose tissue function may promote secondary disease through ectopic lipid accumulation and excess release of adipokines, resulting in systemic low-grade inflammation, insulin resistance ...