Blar i Bergen Open Research Archive på forfatter "Darbakk, Christine"
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Functional characterization of N-terminal acetyltransferase 10 (NAA10) variants potentially causing disease
Darbakk, Christine (Master thesis, 2019-12-14)Approximately 80-90 % of all eukaryotic proteins are co- or post-translationally acetylated on their N-terminus by a group of enzymes called N-terminal acetyltransferases (NATs) (Arnesen et al., 2009). To date, eight NATs ... -
NAA10 p.(D10G) and NAA10 p.(L11R) variants hamper formation of the NatA N-terminal acetyltransferase complex
Mc Tiernan, Nina; Darbakk, Christine; Ree, Rasmus; Arnesen, Thomas (Journal article; Peer reviewed, 2020)The majority of the human proteome is subjected to N-terminal (Nt) acetylation catalysed by N-terminal acetyltransferases (NATs). The NatA complex is composed of two core subunits—the catalytic subunit NAA10 and the ribosomal ...