Browsing Bergen Open Research Archive by Author "Delaleu, Nicolas Hervé"
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The autonomy of different aspects of Sjögren´s syndrome and their treatment in an experimental model: the use of comprehensive biomarker analyses to characterize the disease and the effect of heat-shock proteins in treatment intervention
Delaleu, Nicolas Hervé (Doctoral thesis, 2008-06-20)Sjögren’s syndrome (SS) is a systemic rheumatic disease, in which the salivary and lacrimal glands are the principal targets of a pathological autoimmune reaction. Clinically, SS is manifested by keratoconjunctivitis sicca ... -
Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations
Delaleu, Nicolas Hervé; Immervoll, Heike; Cornelius, Janet; Jonsson, Roland (Peer reviewed; Journal article, 2008-02-20)Introduction Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The aim of this study was to investigate the involvement of 87 proteins measured in serum and 75 proteins ... -
Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in non-obese diabetic mice
Berggreen, Ellen; Nyløkken, Krister; Delaleu, Nicolas Hervé; Hajdaragic-Ibricevic, Hamijeta; Jonsson, Malin Viktoria (Peer reviewed; Journal article, 2009-02-06)Introduction Decreased vascular responses to salivary gland stimulation are observed in Sjögren's syndrome patients. We investigate whether impaired vascular responses to parasympathetic stimulation and muscarinic receptor ... -
Sjögren’s syndrome: studying the disease in mice
Delaleu, Nicolas Hervé; Nguyen, Cuong Q.; Peck, Ammon B.; Jonsson, Roland (Peer reviewed; Journal article, 2011-06-13)Sjögren’s syndrome (SS), a systemic autoimmune disease, is characterized by infl ammation of exocrine tissues accompanied by a signifi cant loss of their secretory function. Clinical symptoms develop late and there are no ... -
Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue's extracellular milieu precede immune responses in Sjögren's syndrome
Delaleu, Nicolas Hervé; Nguyen, Cuong Q.; Tekle, Kidane Mebrahtu; Jonsson, Roland; Peck, Ammon B. (Peer reviewed; Journal article, 2013-10-31)Introduction: Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, ...