• Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 

      Lee, Yunsung; Løkås Haftorn, Kristine; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian; Moen, Gunn-Helen; Magnus, Maria C.; Gjessing, Håkon K.; Harris, Jennifer R.; Magnus, Per; Håberg, Siri E.; Jugessur, Astanand; Bohlin, Jon; Lyle, Robert; Lee-Ødegård, Sindre; Groop, Leif C.; Prasad, Rashmi B.; Sletner, Line; Sommer, Christine (Journal article; Peer reviewed, 2020)
      Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ...
    • Detecting diferentially methylated regions using a fast wavelet‑based approach to functional association analysis 

      Denault, William Robert Paul; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      Background We present here a computational shortcut to improve a powerful wavelet-based method by Shim and Stephens (Ann Appl Stat 9(2):665–686, 2015. https://doi.org/10.1214/14-AOAS776) called WaveQTL that was originally ...
    • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 

      Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit; Lyle, Robert; Gjessing, Håkon Kristian; Malmberg, Anni; Magnus, Maria Christine; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand; Bohlin, Jon (Journal article; Peer reviewed, 2021)
      Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate ...
    • Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents 

      Lubczyńska, Małgorzata J.; Muetzel, Ryan L.; El Marroun, Hanan; Basagaña, Xavier; Strak, Maciej; Denault, William Robert Paul; Jaddoe, Vincent W.V.; Hillegers, Manon; Vernooij, Meike W.; Hoek, Gerard; White, Tonya; Brunekreef, Bert; Tiemeier, Henning; Guxens, Mònica (Journal article; Peer reviewed, 2020)
      Background: Air pollution has been related to brain structural alterations, but a relationship with white matter microstructure is unclear. Objectives: We assessed whether pregnancy and childhood exposures to air ...
    • A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population 

      Denault, William Robert Paul; Romanowska, Julia; Helgeland, Øyvind; Jacobsson, Bo; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      Background Birth weight (BW) is one of the most widely studied anthropometric traits in humans because of its role in various adult-onset diseases. The number of loci associated with BW has increased dramatically since ...
    • Wavelet Screening identifies regions highly enriched for differentially methylated loci for orofacial clefts 

      Denault, William Robert Paul; Romanowska, Julia; Haaland, Øystein Ariansen; Lyle, Robert; Taylor, Jack A.; Xu, Zongli; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)
      DNA methylation is the most widely studied epigenetic mark in humans and plays an essential role in normal biological processes as well as in disease development. More focus has recently been placed on understanding ...