Browsing Bergen Open Research Archive by Author "Dhar, Indu"
Now showing items 1-17 of 17
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B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Bjørnestad, Espen Øglænd; Ulvik, Arve; Saeed, Sahrai; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background Calcium channel blockers (CCBs) are used for the treatment of cardiovascular disease (CVD), including angina pectoris, and hypertension; however, the effect on survival remains uncertain. CCBs impair fibrinolysis ... -
Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease
Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Ørn, Stein; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for ... -
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease
Bjørnestad, Espen Ø.; Olset, Hilde; Dhar, Indu; Løland, Kjetil Halvorsen; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Svardal, Asbjørn M.; Berge, Rolf K; Ueland, Per Magne; Tell, Grethe S.; Nilsen, Dennis W.T.; Jan E., Nordrehaug; Nygaard, Ellisif; Nygård, Ottar (Journal article; Peer reviewed, 2020)Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ... -
Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease
Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2019-09-09)Purpose: We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery ... -
Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients.
Hilvo, M; Meikle, PJ; Pedersen, ER; Tell, Grethe S.; Dhar, Indu; Brenner, H; Schöttker, B; Lääperi, M; Kauhanen, D; Koistinen, KM; Jylhä, A; Huynh, K; Mellett, NA; Tonkin, AM; Sullivan, DR; Simes, J; Nestel, P; Koenig, W; Rothenbacher, D; Nygård, Ottar; Laaksonen, R (Peer reviewed; Journal article, 2020)Aims: Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular death. As phospholipids have also been linked with CVD risk, we investigated whether the ... -
Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease
Dhar, Indu; Lysne, Vegard; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Gregory, Jesse F.; Bønaa, Kaare Harald; Nygård, Ottar (Journal article; Peer reviewed, 2019)Background Elevated circulating cystathionine levels are related to atherosclerotic cardiovascular disease, a leading cause of death globally. Objective We investigated whether plasma cystathionine was associated with ... -
Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin
Dhar, Indu; Siddique, Sumia; Pedersen, Eva Kristine Ringdal; Svingen, Gard FT; Lysne, Vegard; Olsen, Thomas; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S; Nygård, Ottar (Journal article; Peer reviewed, 2020)Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ–mediated ... -
Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Ulvik, Arve; Bjørnestad, Espen Øglænd; Dankel, Simon N; Mellgren, Gunnar; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Physical activity (PA) influences sympathetic stimulation, platelet activation as well as vascular function, and has been associated with improved health outcomes in patients with coronary heart disease. β-blocker ... -
Plasma cystathionine and risk of incident stroke in patients with suspected stable angina pectoris
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Lysne, Vegard; Svenningsson, Mads Malm; Tell, Grethe S.; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background: Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6‐dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, ... -
Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study
Dhar, Indu; Lysne, Vegard; Ulvik, Arve; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Bjørnestad, Espen Øglænd; Olsen, Thomas; Borsholm, Robert Andre; Laupsa-Borge, Johnny; Ueland, Per Magne; Tell, Grethe Seppola; Berge, Rolf Kristian; Mellgren, Gunnar; Bønaa, Kaare Harald; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and is considered a marker of vitamin B12 deficiency. Moreover, MMA-dependent reactions have been ... -
Primary cardiovascular risk prediction by LDL-cholesterol in Caucasian middle-aged and older adults: a joint analysis of three cohorts
Hilvo, Mika; Dhar, Indu; Lääperi, Mitja; Lysne, Vegard; Sulo, Gerhard; Tell, Grethe S.; Jousilahti, Pekka; Nygård, Ottar Kjell; Brenner, Hermann; Schöttker, Ben; Laaksonen, Reijo (Journal article; Peer reviewed, 2022)Aims Low-density lipoprotein cholesterol (LDL-C) is an established causal driver of atherosclerotic cardiovascular disease (ASCVD), but its performance and age-dependency as a biomarker for incident events and mortality ... -
The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A
Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Dhar, Indu; Tell, Grethe S.; Blomhoff, Rune; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background. Plasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease, but the mechanisms remain unclear. Vitamin A (Vit-A) is involved in homocysteine metabolism and we therefore ... -
SGLT1 inhibition boon or bane for diabetes-associated cardiomyopathy
Kalra, Jaspreet; Mangali, Suresh Babu; Dasari, Deepika; Bhat, Audesh; Goyal, Srashti; Dhar, Indu; Sriram, Dharamrajan; Dhar, Arti (Peer reviewed; Journal article, 2020)Chronic hyperglycaemia is a peculiar feature of diabetes mellitus (DM). Sequential metabolic abnormalities accompanying glucotoxicity are some of its implications. Glucotoxicity most likely corresponds to the vascular ... -
Transsulfuration metabolites and the association with incident atrial fibrillation – An observational cohort study among Norwegian patients with stable angina pectoris
Svenningsson, Mads Malm; Svingen, Gard Frodahl Tveitevåg; Lysne, Vegard; Ueland, Per Magne; Tell, Grethe S.; Pedersen, Eva Ringdal; Dhar, Indu; Nilsen, Dennis W.T.; Nygård, Ottar (Journal article; Peer reviewed, 2020)Background/aim Plasma total homocysteine (tHcy) is elevated in patients with persistent vs. paroxysmal atrial fibrillation (AF), and has been related to increased risk of new-onset AF. Homocysteine is degraded to cystathionine ... -
Trimethyllysine predicts all-cause and cardiovascular mortality in community-dwelling adults and patients with coronary heart disease
Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Ørn, Stein; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)Aims Trimethyllysine (TML) is involved in carnitine synthesis, serves as a precursor of trimethylamine N-oxide (TMAO) and is associated with cardiovascular events in patients with established coronary heart disease (CHD). ... -
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial
Borowczyk, Kamila; Piechocka, Justyna; Głowacki, Rafał; Dhar, Indu; Midttun, Øivind; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Jakubowski, Hieronim (Peer reviewed; Journal article, 2018)Objectives: No individual homocysteine (Hcy) metabolite has been studied as a risk marker for coronary artery disease (CAD). Our objective was to examine Hcy‐thiolactone, a chemically reactive metabolite generated by ... -
β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Olsen, Thomas; Lysne, Vegard; Bjørnestad, Espen Øglænd; Ueland, Per Magne; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)Aims Blockade of β-adrenoceptors reduces sympathetic nervous system activity and improves survival in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, any improvement in ...