• Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat 

      Jassim, Goran; Skrede, Silje; Vázquez, María Jesús; Wergedahl, Hege; Vik-Mo, Audun O.; Lunder, Niclas; Diéguez, Carlos; Vidal-Puig, Antonio; Berge, Rolf Kristian; López, Miguel; Steen, Vidar Martin; Fernø, Johan (Peer reviewed; Journal article, 2011-07-12)
      This study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent of ...
    • The brain and brown fat 

      Contreras, Cristina; Gonzalez, Francisco; Fernø, Johan; Diéguez, Carlos; Rahmouni, Kamal; Nogueiras, Rubén; López, Miguel (Peer reviewed; Journal article, 2015-06-10)
      Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and ...
    • Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation 

      Fernø, Johan; Varela, Luis; Skrede, Silje; Vázquez, María Jesús; Nogueiras, Rubén; Diéguez, Carlos; Vidal-Puig, Antonio; Steen, Vidar Martin; López, Miguel (Peer reviewed; Journal article, 2011-06-13)
      The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine ...