Browsing Bergen Open Research Archive by Author "Dick, Fiona"
Now showing items 1-6 of 6
-
Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson's disease
Dick, Fiona; Tysnes, Ole-Bjørn; Alves, Guido Werner; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)Aberrant proteostasis is thought to be implicated in Parkinson’s disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation ... -
Brain Proteome Profiling Reveals Common and Divergent Signatures in Parkinson’s Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy
Dick, Fiona; Johanson, Gard Aasmund Skulstad; Tysnes, Ole-Bjørn; Alves, Guido Werner; Dölle, Christian; Tzoulis, Charalampos (Journal article; Peer reviewed, 2024)The molecular pathogenesis of degenerative parkinsonisms, including Parkinson’s disease (PD), progressive supranuclear palsy (PSP), and Multiple system atrophy (MSA), remains largely unknown. To gain novel insight into ... -
Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition
Sanchez Nido, Gonzalo; Dick, Fiona; Toker, Lilah; Petersen, Kjell; Alves, Guido Werner; Tysnes, Ole-Bjørn; Jonassen, Inge; Haugarvoll, Kristoffer; Tzoulis, Charalampos (Journal article; Peer reviewed, 2020-04-21)The etiology of Parkinson’s disease is largely unknown. Genome-wide transcriptomic studies in bulk brain tissue have identified several molecular signatures associated with the disease. While these studies have the potential ... -
Differential transcript usage in the Parkinson’s disease brain
Dick, Fiona; Sanchez Nido, Gonzalo; Alves, Guido Werner; Tysnes, Ole-Bjørn; Nilsen, Gry Hilde; Dölle, Christian; Tzoulis, Charalampos (Peer reviewed; Journal article, 2020)Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson’s disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, ... -
Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L
Solheim, Eirik Tveit; Gerking, Yola; Kråkenes, Torbjørn; Herdlevær, Ida; Birkeland, Even; Totland, Cecilie; Dick, Fiona; Vedeler, Christian Alexander (Journal article; Peer reviewed, 2024)Background Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens ... -
Studies of gene expression in the Parkinson’s disease brain
Dick, Fiona (Doctoral thesis, 2021-10-01)Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, affecting ~1.8% of the population above 65 years. A combination of genetic and environmental factors contributes to the risk of PD, but the ...