Blar i Bergen Open Research Archive på forfatter "Donald, Carey"
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Alkyl-phenanthrenes in early life stage fish: differential toxicity in Atlantic haddock (Melanogrammus aeglefinus) embryos
Donald, Carey; Nakken, Charlotte L.; Sørhus, Elin; Perrichon, Prescilla; Jørgensen, Kåre Bredeli; Bjelland, Hege K.; Stølen, Christine; Kancherla, Sindhu; Mayer, Philipp; Meier, Sonnich (Journal article; Peer reviewed, 2023)Tricyclic polycyclic aromatic hydrocarbons (PAHs) are believed to be the primary toxic components of crude oil. Such compounds including phenanthrene are known to have direct effects on cardiac tissue, which lead to ... -
Co-Exposure of Phenanthrene and the cyp-Inducer 3-Methylchrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae
Donald, Carey; Sørhus, Elin; Perrichon, Prescilla; Nakken, Charlotte L.; Goksøyr, Anders; Jørgensen, Kåre Bredeli; Mayer, Philipp; da Silva, Denis A.M.; Meier, Sonnich (Journal article; Peer reviewed, 2023)Polycyclic aromatic hydrocarbons (PAHs) have frequently been suspected of governing crude oil toxicity because of similar morphological defects in fish. However, PAH concentrations are often not high enough to explain the ... -
Co-exposure to UV radiation and crude oil increases acute embryotoxicity and sublethal malformations in the early life stages of Atlantic haddock (Melanogrammus aeglefinus)
Sørhus, Elin; Donald, Carey; Nakken, Charlotte L.; Perrichon, Prescilla; Durif, Caroline; Shema, Steven; Browman, Howard; Skiftesvik, Anne Berit; Lie, Kai Kristoffer; Rasinger, Josef; Müller, Mette Helen Bjørge; Meier, Sonnich (Journal article; Peer reviewed, 2023)Crude oil causes severe abnormalities in developing fish. Photomodification of constituents in crude oil increases its toxicity several fold. We report on the effect of crude oil, in combination with ultraviolet (UV) ... -
Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene
Nakken, Charlotte Langeland; Meier, Sonnich; Mjøs, Svein Are; Bijlsma, Lubertus; Rowland, Steven J; Donald, Carey (Journal article; Peer reviewed, 2024)Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated ... -
Exposure of Polycyclic Aromatic Hydrocarbons (PAHs) and Crude Oil to Atlantic Haddock (Melanogrammus aeglefinus): A Unique Snapshot of the Mercapturic Acid Pathway
Nakken, Charlotte Langeland; Berntssen, Marc HG; Meier, Sonnich; Bijlsma, Lubertus; Mjøs, Svein Are; Sørhus, Elin; Donald, Carey (Journal article; Peer reviewed, 2024)Fish exposed to xenobiotics like petroleum-derived polycyclic aromatic hydrocarbons (PAHs) will immediately initiate detoxification systems through effective biotransformation reactions. Yet, there is a discrepancy between ... -
Expression and localization of the aryl hydrocarbon receptors and cytochrome P450 1A during early development of Atlantic cod (Gadus morhua)
Aranguren Abadía, Libe; Donald, Carey; Eilertsen, Mariann; Gharbi, Naouel; Tronci, Valentina; Sørhus, Elin; Mayer, Philipp; Nilsen, Tom Ole; Meier, Sonnich; Goksøyr, Anders; Karlsen, Odd Andre (Journal article; Peer reviewed, 2020)The aryl hydrocarbon receptor (Ahr) is a ligand-activated transcription factor that mediates the toxicity of dioxins and dioxin-like compounds (DLCs) in vertebrates. Two clades of the Ahr family exist in teleosts (Ahr1 and ... -
Mind the gap – Relevant design for laboratory oil exposure of fish as informed by a numerical impact assessment model
Frøysa, Håvard Guldbrandsen; Nepstad, Raymond; Meier, Sonnich; Donald, Carey; Sørhus, Elin; Bockwoldt, Mathias; Carroll, JoLynn; Vikebø, Frode Bendiksen (Journal article; Peer reviewed, 2023)Laboratory experiments provide knowledge of species-specific effects thresholds that are used to parameterize impact assessment models of oil contamination on marine ecosystems. Such experiments typically place individuals ... -
Photo-enhanced toxicity of crude oil on early developmental stages of Atlantic cod (Gadus morhua)
Aranguren Abadía, Libe; Yadetie, Fekadu; Donald, Carey; Sørhus, Elin; Myklatun, Lars Eirik; Zhang, Xiaokang; Lie, Kai Kristoffer; Perrichon, Prescilla; Nakken, Charlotte Langeland; Durif, Caroline; Shema, Steven; Browman, Howard; Skiftesvik, Anne Berit; Goksøyr, Anders; Meier, Sonnich; Karlsen, Odd André (Journal article; Peer reviewed, 2022)Photo-enhanced toxicity of crude oil is produced by exposure to ultraviolet (UV) radiation. Atlantic cod (Gadus morhua) embryos were exposed to crude oil with and without UV radiation (290–400 nm) from 3 days post fertilization ...