Browsing Bergen Open Research Archive by Author "Dyer, Laurence"
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Meal patterns associated with energy intake in people with obesity
Horn, Cathrine; Laupsa-Borge, Johnny; Andersen, Amanda; Dyer, Laurence; Revheim, Ingrid; Leikanger, Trine; Næsheim, Nicole Tandrevold; Storås, Inghild; Johannessen, Kristine Kjerpeseth; Mellgren, Gunnar; Dierkes, Jutta; Dankel, Simon N (Journal article; Peer reviewed, 2022)It is widely assumed that people with obesity have several common eating patterns, including breakfast-skipping (1), eating during the night (2) and high fast-food consumption (3). However, differences in individual meal ... -
Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
Bjune, Mona Synnøve; Dyer, Laurence; Laupsa-Borge, Johnny; Sommersten, Cathrine Horn; McCann, Adrian; Glastad, Robert Clay; Johnston, Iain; Kern, Matthias; Blüher, Matthias; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2023)Background: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated ... -
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance
Jersin, Regine Åsen; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona Synnøve; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ... -
Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance
Strand, Kristina; Stiglund, Natalie; Haugstøyl, Martha Eimstad; Kamyab, Seyedeh Zahra; Langhelle, Victoria Puntervold; Dyer, Laurence; Busch, Christian; Cornillet, Martin; Hjellestad, Iren Drange; Nielsen, Hans Jørgen; Njølstad, Pål Rasmus; Mellgren, Gunnar; Björkström, Niklas K.; Fernø, Johan (Journal article; Peer reviewed, 2022)A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis ...