• Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 

      Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2019)
      Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, virally ...
    • Adenosine Deaminase Activity Is a Sensitive Marker for the Diagnosis of Tuberculous Pleuritis in Patients with Very Low CD4 Counts 

      Baba, Kamaldeen; Hoosen, Anwar A.; Langeland, Nina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2008-07-30)
      Background: Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive ...
    • Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID‑19 

      Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Stiksrud, Birgitte; Berge, Tone; Barratt-Due, Andreas; Aukrust, Pål; Heggelund, Lars; Blennow, Kaj; Zetterberg, Henrik; Harbo, Hanne Flinstad; Quist‑Paulsen, Else (Journal article; Peer reviewed, 2021)
      Objective To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for ...
    • Burden and characteristics of the comorbidity tuberculosis - diabetes in Europe : TBnet prevalence survey and case-control study 

      Sane Schepisi, Monica; Navarra, Assunta; Altet Gómez, Maria de las Nieves; Dudnyk, Andrii; Dyrhol-Riise, Anne Ma; Esteban, Jaime; Giorgetti, Pier Francesco; Gualano, Gina; Guglielmetti, Lorenzo; Heyckendorf, Jan; Kaluzhenina, Anna; Lange, Berit; Lange, Christoph; Manika, Katerina; Miah, Jalal; Nanovic, Zorica; Pontali, Emanuele; Prego, Monica Rios; Solovič, Ivan; Tiberi, Simon; Palmieri, Fabrizio; Girardi, Enrico (Peer reviewed; Journal article, 2019-01)
      Background: The growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment ...
    • Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the ISARIC WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study 

      Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan J.C.; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan Ahmad; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, François; Bekken, Gry Klouman; Dudman, Susanne Gjeruldsen; Dyrhol-Riise, Anne Ma; Heggelund, Lars; Hesstvedt, Liv; Holten, Aleksander Rygh; Holter, Jan Cato; Jenum, Synne; Johal, Simreen Kaur; Lind, Andreas; Müller, Fredrik; Muller, Karl Erik; Pettersen, Frank O.; Quist-Paulsen, Else; Reikvam, Dag Henrik; Skeie, Linda Gail; Skogen, Vegard; Stiksrud, Birgitte; Tonby, Kristian (Journal article; Peer reviewed, 2022)
      Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained ...
    • The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection 

      Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2016-10-24)
      Background: Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. ...
    • Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice 

      Mortensen, Rasmus; Clemmensen, Helena Strand; Woodworth, Joshua S.; Therkelsen, Marie Louise; Mustafa, Tehmina; Tonby, Kristian; Jenum, Synne; Agger, Else Marie; Dyrhol-Riise, Anne Ma; Andersen, Peter (Peer reviewed; Journal article, 2019)
      Tuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health ...
    • Cytokine Patterns in Tuberculosis Infection; IL-1ra, IL-2 and IP-10 Differentiate Borderline QuantiFERON-TB Samples from Uninfected Controls 

      Wergeland, Ida; Assmus, Jörg; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2016-09-29)
      Background: Interferon gamma release assays (IGRAs) do not discriminate between active tuberculosis (TB) and latent TB infection (LTBI), which limit their use in TB endemic areas. Subjects with QuantiFERON-TB (QFT) results ...
    • Detailed stratified GWAS analysis for severe COVID-19 in four European populations 

      Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Müller, Fredrik; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Dudman, Susanne Gjeruldsen; Folseraas, Trine; Skogen, Vegard; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Rühlemann, Malte C.; Arora, Jatin; Özer, Onur; Wacker, Eike Matthias; Wienbrandt, Lars; Ortiz, Aron Blandino; de Salazar, Adolfo; Chercoles, Adolfo Garrido; Palom, Adriana; Ruiz, Agustin; Garzia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Mayer, Alena; Bandera, Alessandra; Franke, Andre (Journal article; Peer reviewed, 2022)
      Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ...
    • Diagnosis and follow-up of treatment of latent tuberculosis; the utility of the QuantiFERON-TB Gold In-tube assay in outpatients from a tuberculosis low-endemic country 

      Dyrhol-Riise, Anne Ma; Gran, Gerd; Wentzel-Larsen, Tore; Blomberg, Bjørn; Haanshuus, Christel Gill; Mørkve, Odd (Peer reviewed; Journal article, 2010-03-08)
      Background Interferon-gamma (IFN-γ) Release Assays (IGRA) are more specific than the tuberculosis skin test (TST) in the diagnosis of latent tuberculosis (TB) infection (LTBI). We present the performance of the QuantiFERON®-TB ...
    • Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting 

      Hoel, Ida Marie; Sviland, Lisbeth; Syre, Heidi; Dyrhol-Riise, Anne Ma; Skarstein, Ingerid; Jebsen, Peter Wilhelm; Jørstad, Melissa Davidsen; Wiker, Harald G; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)
      Background Extrapulmonary tuberculosis (EPTB) poses diagnostic challenges due to the paucibacillary nature of the disease. The immunochemistry-based MPT64 antigen detection test (MPT64 test) has shown promising results ...
    • DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients 

      Olsen, Maria Belland; Huse, Camilla; Sousa, Mirta; Murphy, Sarah Louise Mikalsen; Sarno, Antonio; Obermann, Tobias Sebastian; Yang, Kuan; Holter, Jan Cato; Jørgensen, Marthe Jøntvedt; Christensen, Erik Egeland; Wang, Wei; Ji, Ping; Heggelund, Lars; Hoel, Hedda; Dyrhol-Riise, Anne Ma; Gregersen, Ida; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente; Dahl, Tuva Børresdatter (Journal article; Peer reviewed, 2022)
      Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ...
    • Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement 

      Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor; Michelsen, Annika; Otterdal, Kari; Muller, Karl Erik; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma; Holter, Jan Cato; Trøseid, Marius (Journal article; Peer reviewed, 2021)
      Background A high proportion of COVID‐19 patients have cardiac involvement, even those without known cardiac disease. Downregulation of angiotensin converting enzyme 2 (ACE2), a receptor for SARS‐CoV‐2 and the renin‐angiotensin ...
    • Evaluation of immune responses in HIV infected patients with pleural tuberculosis by the QuantiFERON® TB-Gold interferon-gamma assay 

      Baba, Kamaldeen; Sørnes, Steinar; Hoosen, Anwar A.; Lekabe, Jacob M.; Mpe, Mathew J.; Langeland, Nina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2008-03-14)
      Background: Diagnosis of tuberculous (TB) pleuritis is difficult and better diagnostic tools are needed. New blood based interferon-gamma (IFN-γ) tests are promising, but sensitivity could be low in HIV positive patients. ...
    • Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting 

      Jørstad, Melissa Davidsen; Dyrhol-Riise, Anne Ma; Aßmus, Jörg; Marijani, Msafiri; Sviland, Lisbeth; Mustafa, Tehmina (Peer reviewed; Journal article, 2019-05-16)
      Background Diagnosing extrapulmonary tuberculosis (EPTB) is challenging and many patients are initiated on empirical anti-TB treatment without a laboratory confirmed diagnosis. Monitoring treatment response is thus important ...
    • Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19 

      Trøseid, Marius; Holter, Jan Cato; Holm, Kristian; Vestad, Beate; Sazonova, Taisiia; Granerud, Beathe Kiland; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh; Tonby, Kristian; Kildal, Anders Benjamin; Heggelund, Lars; Tveita, Anders Aune; Bøe, Simen; Müller, Karl Erik; Jenum, Synne; Hov, Johannes Espolin Roksund; Ueland, Thor (Journal article; Peer reviewed, 2023)
      Background Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut ...
    • High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections 

      Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2018-11-23)
      Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces ...
    • HIV patients with latent tuberculosis living in a low-endemic country do not develop active disease during a 2 year follow-up; a Norwegian prospective multicenter study 

      Pullar, Nadine Durema; Steinum, Harald; Bruun, Johan Nikolai; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2014-12-17)
      Background: Interferon-γ release assays (IGRA) serve as immunodiagnostics of tuberculosis (TB) infection to identify individuals with latent TB infection (LTBI) eligible for preventive anti-TB therapy. In this longitudinal ...
    • Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial 

      Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (Peer reviewed; Journal article, 2017-05-02)
      Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ...
    • In vitro analysis of antigen induced T cell-monocyte conjugates by imaging flow cytometry 

      Mekonnen, Meseret Habtamu; Abebe, Markos; Aseffa, Abraham; Dyrhol-Riise, Anne Ma; Spurkland, Anne; Abrahamsen, Greger (Peer reviewed; Journal article, 2018)
      There is a lack of suitable correlates of immune protection against Mycobacterium tuberculosis (Mtb) infection. T cells and monocytes play key roles in host immunity against Mtb. Thus, a method that allows assessing their ...