Browsing Bergen Open Research Archive by Author "Edson, Amanda Jayne"

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Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction

Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Edson, Amanda Jayne; Goris, Marianne; Altankhuyag, Altanchimeg; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2019)

Biomolecular interactions between proteins and polyphosphoinositides (PPIn) are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the ...
Reintroduction of dj-1 in müller cells inhibits retinal degeneration in the dj-1 deficient retina

Gharbi, Naouel; Røise, Dagne; Førre, Jorunn-Elise; Edson, Amanda Jayne; Hushagen, Helena Amalie; Tronci, Valentina; Frøyset, Ann-Kristin; Fladmark, Kari E. (Journal article; Peer reviewed, 2021)

The eye is continuously under oxidative stress due to high metabolic activity and reactive oxygen species generated by daily light exposure. The redox-sensitive protein DJ-1 has proven to be essential in order to protect ...
SAF-A/hnRNP U binds polyphosphoinositides via a lysine rich polybasic motif located in the SAP domain

Edson, Amanda Jayne; Jacobsen, Rhian Gaenor; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2023)

Polyphosphoinositides (PPIn) play essential functions as lipid signalling molecules and many of their functions have been elucidated in the cytoplasm. However, PPIn are also intranuclear where they contribute to chromatin ...