Browsing Bergen Open Research Archive by Author "Eigenmann, Miro Julian"

Now showing items 1-2 of 2

    • Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches 

      Eigenmann, Miro Julian; Karlsen, Tine Veronica; Krippendorff, Ben-Fillippo; Tenstad, Olav; Fronton, Ludivine; Otteneder, Michael B.; Wiig, Helge (Peer reviewed; Journal article, 2017-12)
      For most therapeutic antibodies, the interstitium is the target space. Although experimental methods for measuring antibody pharmacokinetics (PK) in this space are not well established, thus making quantitative assessment ...

    • Pharmacokinetics and pharmacodynamics of t-cell bispecifics in the tumour interstitial fluid 

      Eigenmann, Miro Julian; Karlsen, Tine Veronica; Wagner, Marek; Tenstad, Olav; Weinzierl, Tina; Fauti, Tanja; Grimm, Hans Peter; Skogstrand, Trude; Klein, Christian; Sam, Johannes; Umana, Pablo; Bacac, Marina; Wiig, Helge; Walz, Antje-Christine (Journal article; Peer reviewed, 2021)
      The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent ...