Blar i Bergen Open Research Archive på forfatter "Eikrem, Øystein Solberg"
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Abnormal Uroguanylin Immunoreactive Cells Density in the Duodenum of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Changes following Fecal Microbiota Transplantation
Mazzawi, Tarek; Eikrem, Øystein Solberg; Lied, Gülen Arslan; Hausken, Trygve (Journal article; Peer reviewed, 2020)Altered densities of enteroendocrine cells play an important role in patients with irritable bowel syndrome (IBS). Uroguanylin activates guanylate cyclase-C to regulate intestinal electrolyte and water transport. Aim. To ... -
AGAP2-AS1 as a prognostic biomarker in low-risk clear cell renal cell carcinoma patients with progressing disease
Strauss, Philipp; Marti, Hans-Peter; Furriol, Jessica; Nakken, Sigrid; Vidar, Beisvåg; Eikrem, Øystein Solberg; Beisland, Christian; Flatberg, Arnar; Bostad, Leif; Scherer, Andreas; Eleni, Skandalou (Journal article; Peer reviewed, 2021)Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and one of the most common cancers. While survival for localized ccRCC is good, the survival of metastatic disease is not, and ... -
AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction
Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ... -
Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis
Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter (Peer reviewed; Journal article, 2017)Clear cell renal cell carcinoma (ccRCC) represents the most common type of kidney cancer with high mortality in its advanced stages. Our study aim was to explore the correlation between tumor epithelial-to-mesenchymal ... -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2018-03-10)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys
Eikrem, Øystein Solberg; Walther, Tedd Christian; Flatberg, Arnar; Beisvag, Vidar; Strauss, Philipp; Farstad, Magnus; Beisland, Christian; Koch, Even; Mueller, Thomas F.; Marti, Hans-Peter (Peer reviewed; Journal article, 2018-09-18)Background: Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current ... -
A multiomics disease progression signature of low-risk ccRCC
Strauss, Philipp; Rivedal, Mariell; Scherer, Andreas; Eikrem, Øystein Solberg; Nakken, Sigrid; Beisland, Christian; Bostad, Leif; Flatberg, Arnar; Skandalou, Eleni; Beisvag, Vidar; Furriol, Jessica; Marti, Hans Peter (Journal article; Peer reviewed, 2022)Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ... -
New methods clear the dust off old biopsies. RNA sequencing of FFPE kidney biopsies
Eikrem, Øystein Solberg (Doctoral thesis, 2019-06-07)Background and aims: Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. We wanted to exploit renal biopsies also on the mRNA level to elucidate pathophysiological mechanisms ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
Eikrem, Øystein Solberg; Beisland, Christian; Hjelle, Karin Margrethe; Flatberg, Arnar; Scherer, Andreas; Landolt, Lea Zoe; Skogstrand, Trude; Leh, Sabine Maria; Beisvag, Vidar; Marti, Hans-Peter (Peer reviewed; Journal article, 2016-02-22)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ... -
Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys
Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ...