Browsing Bergen Open Research Archive by Author "El Jellas, Khadija"
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Carboxyl-ester lipase in human pancreatic disease. A study with focus on genetics, glycosylation and ABO blood groups
El Jellas, Khadija (Doctoral thesis, 2018-09-28)Glycosylation is a post-translational modification where carbohydrates are attached to a protein or other organic molecule. Defects in glycosylation are seen in many human pathologies and may even be the underlying cause ... -
The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants
El Jellas, Khadija; Johansson, Bente Berg; Fjeld, Karianne; Antonopoulos, Aristotelis; Immervoll, Heike; Choi, Man Hung; Hoem, Dag; Lowe, Mark E.; Lombardo, Dominique; Njølstad, Pål Rasmus; Dell, Anne; Mas, Eric; Haslam, Stuart M.; Molven, Anders (Peer reviewed; Journal article, 2018)Carboxyl-ester lipase (CEL) is a pancreatic fat-digesting enzyme associated with human disease. Rare mutations in the CEL gene cause a syndrome of pancreatic exocrine and endocrine dysfunction denoted MODY8, whereas a ...