Browsing Bergen Open Research Archive by Author "El-Salhy, Magdy"
Now showing items 1-20 of 29
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Amelioration of Severe TNBS Induced Colitis by Novel AP-1 and NF-κB Inhibitors in Rats
El-Salhy, Magdy; Umezawa, Kazuo; Gilja, Odd Helge; Hatlebakk, Jan G; Gundersen, Doris Irene; Hausken, Trygve (Peer reviewed; Journal article, 2014-01-30)AP-1 and NF-κB inhibitors, namely, DTCM-G and DHMEQ, were investigated in male Wistar rats with severe colitis, induced by TNBS. The animals were randomized into 3 groups. The control group received 0.5 mL of 0.5% of the ... -
Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome
El-Salhy, Magdy; Valeur, Jørgen; Hausken, Trygve; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2020)Background Short‐chain fatty acids (SCFAs) may play a role in the pathophysiology of irritable bowel syndrome (IBS). This study analyzed fecal SCFAs after performing fecal microbiota transplantation (FMT) in the IBS ... -
Changes in the symptom pattern and the densities of large-intestinal endocrine cells following Campylobacter infection in irritable bowel syndrome: a case report
El-Salhy, Magdy; Mazzawi, Tarek; Gundersen, Doris; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2013-09-29)Background Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder. Post-infectious IBS (PI-IBS) is a subset of IBS that accounts for a large proportion of IBS patients. The PI-IBS symptoms ... -
Chromogranin A Cell Density as a Diagnostic Marker for Lymphocytic Colitis
El-Salhy, Magdy; Gundersen, Doris; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2012-06-15)Background: Lymphocytic colitis (LC) can be mistakenly diagnosed as irritable bowel syndrome (IBS). In a previous study on IBS, some patients showed extremely high colonic chromogranin A cell density. Further examination ... -
Chromogranin A cells in the stomachs of patients With sporadic irritable bowel syndrome
El-Salhy, Magdy; Gilja, Odd Helge; Hausken, Trygve (Peer reviewed; Journal article, 2014-10)Several abnormalities have been demonstrated in the intestines of patients with irritable bowel syndrome (IBS); however, the endocrine cells in the stomachs of these patients have not been investigated. The aim of the ... -
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels
Mazzawi, Tarek; Hausken, Trygve; Hov, Johannes Espolin Roksund; Valeur, Jørgen; Sangnes, Dag André; El-Salhy, Magdy; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Lied, Gülen Arslan (Peer reviewed; Journal article, 2019)Objectives: Irritable bowel syndrome (IBS) may be associated with disturbances in gut microbiota composition and functions. We recently performed a study of fecal microbiota transplantation (FMT) in diarrhea-predominant ... -
Densities of rectal peptide YY and somatostatin cells as biomarkers for the diagnosis of irritable bowel syndrome
El-Salhy, Magdy; Hatlebakk, Jan G; Gilja, Odd Helge; Hausken, Trygve (Peer reviewed; Journal article, 2015-03-09)Irritable bowel syndrome (IBS) is a common chronic disorder. IBS diagnosis is a diagnosis of exclusion since there are no blood tests, radiological or endoscopic examinations for this disorder. Although several attempts ... -
Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome
El-Salhy, Magdy; Hausken, Trygve; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2020)Irritable bowel syndrome (IBS) affects ~12% of the global population. Although the etiology of IBS is not completely understood, several factors are known to serve a pivotal role in its pathophysiology, including genetic ... -
Diet in irritable bowel syndrome
El-Salhy, Magdy; Gundersen, Doris Irene (Peer reviewed; Journal article, 2015-04-14)Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that is characterized by intermittent abdominal pain/discomfort, altered bowel habits and abdominal bloating/distension. This review aimed at ... -
Diet in Irritable Bowel Syndrome (IBS): Interaction with Gut Microbiota and Gut Hormones
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2019-08-07)Diet plays an important role not only in the pathophysiology of irritable bowel syndrome (IBS), but also as a tool that improves symptoms and quality of life. The effects of diet seem to be a result of an interaction with ... -
Dietary guidance normalizes large intestinal endocrine cell densities in patients with irritable bowel syndrome
Mazzawi, Tarek; Hausken, Trygve; Gundersen, Doris Irene; El-Salhy, Magdy (Peer reviewed; Journal article, 2015-11-25)Background/Objectives: To determine the large intestinal endocrine cell types affected following dietary guidance in patients with irritable bowel syndrome (IBS). Subjects/Methods: The study included 13 IBS patients and ... -
Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome
El-Salhy, Magdy; Gilja, Odd Helge; Gundersen, Doris Irene; Hatlebakk, Jan G; Hausken, Trygve (Peer reviewed; Journal article, 2014-06-16)Background and Aim. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS). Methods. The present study was undertaken to ... -
Effect of dietary management on the gastric endocrine cells in patients with irritable bowel syndrome
Mazzawi, Tarek; Hausken, Trygve; Gundersen, Doris; El-Salhy, Magdy (Peer reviewed; Journal article, 2014-08-06)Background/objectives: The gastric endocrine cells in patients with irritable bowel syndrome (IBS) tend to normalize following dietary guidance. The aim of the present study was to identify the gastric endocrine cell types ... -
Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome
Mazzawi, Tarek; Hausken, Trygve; Gundersen, Doris Irene; El-Salhy, Magdy (Peer reviewed; Journal article, 2013-09)Diet is important in triggering the symptoms of irritable bowel syndrome (IBS). This study investigated the impact of dietary guidance on the symptoms, quality of life and habitual diet of patients with IBS. Forty‑six ... -
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Gilja, Odd Helge; Bråthen Kristoffersen, Anja; Hausken, Trygve (Peer reviewed; Journal article, 2020)Objective: Faecal microbiota transplantation (FMT) from healthy donors to patients with irritable bowel syndrome (IBS) has been attempted in two previous double-blind, placebo-controlled studies. While one of those studies ... -
Endocrine cells in the ileum of patients with irritable bowel syndrome
El-Salhy, Magdy; Gilja, Odd Helge; Gundersen, Doris Irene; Hatlebakk, Jan G; Hausken, Trygve (Peer reviewed; Journal article, 2014-03-07)AIM: To study the ileal endocrine cell types in irritable bowel syndrome (IBS) patients. METHODS: Ninety-eight patients with IBS (77 females and 21 males; mean age 35 years, range 18-66 years) were included, of which 35 ... -
Endocrine cells in the oxyntic mucosa of the stomach in patients with irritable bowel syndrome
El-Salhy, Magdy; Gilja, Odd Helge; Gundersen, Doris Irene; Hausken, Trygve (Peer reviewed; Journal article, 2014-05)AIM: To study the different endocrine cell types in the oxyntic mucosa of patients with irritable bowel syndrome (IBS). METHODS: Seventy-six patients with IBS were included in the study (62 females and 14 males; mean age ... -
Increased chromogranin A cell density in the large intestine of patients with irritable bowel syndrome after receiving dietary guidance
Mazzawi, Tarek; Gundersen, Doris Irene; Hausken, Trygve; El-Salhy, Magdy (Peer reviewed; Journal article, 2015)The large intestine contains five types of endocrine cells that regulate its functions by sensing its luminal contents and releasing specific hormones. Chromogranin A (CgA) is a common marker for the gastrointestinal ... -
Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome
Mazzawi, Tarek; Gundersen, Doris; Hausken, Trygve; El-Salhy, Magdy (Peer reviewed; Journal article, 2014-11)The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated ... -
Increasing the Dose and/or Repeating Faecal Microbiota Transplantation (FMT) Increases the Response in Patients with Irritable Bowel Syndrome (IBS)
El-Salhy, Magdy; Hausken, Trygve; Hatlebakk, Jan Gunnar (Peer reviewed; Journal article, 2019-06-24)Background: Faecal microbiome transplantation (FMT) appears to be an effective method for treating irritable bowel syndrome (IBS) patients. However, it is not clear if a high transplant dose and/or repeating FMT are/is ...