• Adults with attention-deficit/hyperactivity disorder. A brain magnetic resonance spectroscopy study 

      Dramsdahl, Margaretha; Ersland, Lars; Plessen, Kerstin von; Haavik, Jan; Hugdahl, Kenneth; Specht, Karsten (Peer reviewed; Journal article, 2011-11-23)
      Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the ...
    • Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy 

      Erchinger, Vera Jane; Miller, Jeremy; Jones, Thomas; Kessler, Ute; Bustillo, Juan R.; Haavik, Jan; Petrillo, Jonathan; Ziomek, Gregory; Hammar, Åsa; Ødegaard, Ketil Joachim; Calhoun, Vince D.; McClintock, Shawn M.; Ersland, Lars; Oltedal, Leif; Abbott, Christopher (Journal article; Peer reviewed, 2020-09-17)
      Objective The anticonvulsant hypothesis posits that ECT’s mechanism of action is related to enhancement of endogenous anticonvulsant brain mechanisms. Results of prior studies investigating the role of the inhibitory ...
    • Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites 

      Mikkelsen, Mark; Rimbault, Daniel L.; Barker, Peter B.; Bhattacharyya, Pallab K.; Brix, Maiken Kirkegaard; Buur, Pieter F.; Cecil, Kim M.; Chan, Kimberly L.; Chen, David Y.-T.; Craven, Alexander R.; Cuypers, Koen; Dacko, Michael; Duncan, Niall W.; Dydak, Ulrike; Edmondson, David A.; Ende, Gabriele; Ersland, Lars; Forbes, Megan A.; Gao, Fei; Greenhouse, Ian; Harris, Ashley D.; He, Naying; Heba, Stefanie; Hoggard, Nigel; Hsu, Tun-Wei; Jansen, Jacobus F.A.; Kangarlu, Alayar; Lange, Thomas; Lebel, R. Marc; Li, Yan; Lin, Chien-Yuan E.; Liou, Jy-Kang; Lirng, Jiing-Feng; Liu, Feng; Long, Joanna R.; Ma, Ruoyun; Maes, Celine; Moreno-Ortega, Marta; Murray, Scott O.; Noah, Sean; Noeske, Ralph; Noseworthy, Michael D.; Oeltzschner, Georg; Porges, Eric C.; Prisciandaro, James J.; Puts, Nicolaas A.J.; Roberts, Timothy P.L.; Sack, Markus; Sailasuta, Napapon; Saleh, Muhammad G.; Schallmo, Michael-Paul; Simard, Nicholas; Stoffers, Diederick; Swinnen, Stephan P.; Tegenthoff, Martin; Truong, Peter; Wang, Guangbin; Wilkinson, Iain D.; Wittsack, Hans-Jörg; Woods, Adam J.; Xu, Hongmin; Yan, Fuhua; Zhang, Chencheng; Zipunnikov, Vadim; Zöllner, Helge J.; Edden, Richard A.E. (Peer reviewed; Journal article, 2019)
      Accurate and reliable quantification of brain metabolites measured in vivo using 1H magnetic resonance spectroscopy (MRS) is a topic of continued interest. Aside from differences in the basic approach to quantification, ...
    • “Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited” 

      Brix, Maiken Kirkegaard; Ersland, Lars; Hugdahl, Kenneth; Grüner, Renate; Posserud, Maj-Britt; Hammar, Åse; Craven, Alexander R.; Noeske, Ralph; Evans, C. John; Walker, Hanne B.; Midtvedt, Tore; Beyer, Mona K. (Peer reviewed; Journal article, 2015-06-22)
      Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) ...
    • Combined fMRI Region- and Network-Analysis Reveal New Insights of Top-Down Modulation of Bottom-Up Processes in Auditory Laterality 

      Kazimierczak, Katarzyna; Craven, Alexander R.; Ersland, Lars; Specht, Karsten; Dumitru, Magda L.; Sandøy, Lydia B.; Hugdahl, Kenneth (Journal article; Peer reviewed, 2022)
      Dichotic listening along with the right-ear advantage (REA) has been a standard method of investigating auditory laterality ever since it was first introduced into neuropsychology in the early 1960s. Beginning in the 1980s, ...
    • Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites 

      Považan, Michal; Mikkelsen, Mark; Berrington, Adam; Bhattacharyya, Pallab K.; Brix, Maiken Kirkegaard; Buur, Pieter F.; Cecil, Kim M.; Chan, Kimberly L.; Chen, David Y.T.; Craven, Alexander R.; Cuypers, Koen; Dacko, Michael; Duncan, Niall W.; Dydak, Ulrike; Edmondson, David A.; Ende, Gabriele; Ersland, Lars; Forbes, Megan A.; Gao, Fei; Ian, Greenhouse; Harris, Ashley D.; He, Naying; Heba, Stefanie; Hoggard, Nigel; Hsu, Tun-Wei; Jansen, Jacobus F. A.; Kangarlu, Alayar; Lange, Thomas; Lebel, R. Marc; Li, Yan; Lin, Chien-Yuan E.; Liou, Jy-Kang; Lirng, Jiing-Feng; Liu, Feng; Long, Joanna R.; Ma, Ruoyun; Maes, Celine; Moreno-Ortega, Marta; Murray, Scott O.; Noah, Sean; Noeske, Ralph; Noseworthy, Michael D.; Oeltzschner, Georg; Porges, Eric C.; Prisciandaro, James J.; Puts, Nicolaas A. J.; Roberts, Timothy P. L.; Sack, Markus; Sailasuta, Napapon; Saleh, Muhammad G.; Schallmo, Michael-Paul; Simard, Nicholas; Stoffers, Diederick; Swinnen, Stephan P.; Tegenthoff, Martin; Truong, Peter; Wang, Guangbin; Wilkinson, Iain D.; Wittsack, Hans-Jörg; Woods, Adam J.; Xu, Hongmin; Yan, Fuhua; Zhang, Chencheng; Zipunnikov, Vadim; Zöllner, Helge J.; Edden, Richard A.E.; Barker, Peter B. (Journal article; Peer reviewed, 2020)
      Background: The hardware and software differences between MR vendors and individual sites influence the quantification of MR spectroscopy data. An analysis of a large data set may help to better understand sources of the ...
    • Comparison of seven modelling algorithms for γ-aminobutyric acid–edited proton magnetic resonance spectroscopy 

      Craven, Alexander R.; Bhattacharyya, Pallab K.; Clarke, William T.; Dydak, Ulrike; Edden, Richard A.E.; Ersland, Lars; Mandal, Pravat K.; Mikkelsen, Mark; Murdoch, James B.; Near, Jamie; Rideaux, Reuben; Shukla, Deepika; Wang, Min; Wilson, Martin; Zöllner, Helge J.; Hugdahl, Kenneth Jan; Oeltzschner, Georg (Journal article; Peer reviewed, 2022)
      Edited MRS sequences are widely used for studying γ-aminobutyric acid (GABA) in the human brain. Several algorithms are available for modelling these data, deriving metabolite concentration estimates through peak fitting ...
    • Comparison of seven modelling algorithms for γ-aminobutyric acid–edited proton magnetic resonance spectroscopy 

      Craven, Alexander R.; Bhattacharyya, Pallab K.; Clarke, William T.; Dydak, Ulrike; Edden, Richard A.E.; Ersland, Lars; Mandal, Pravat K.; Mikkelsen, Mark; Murdoch, James B.; Near, Jamie; Rideaux, Reuben; Shukla, Deepika; Wang, Min; Wilson, Martin; Zöllner, Helge J.; Hugdahl, Kenneth; Oeltzschner, Georg (Journal article; Peer reviewed, 2022)
      Edited MRS sequences are widely used for studying γ-aminobutyric acid (GABA) in the human brain. Several algorithms are available for modelling these data, deriving metabolite concentration estimates through peak fitting ...
    • Default-mode network functional connectivity is closely related to metabolic activity 

      Passow, Susanne; Specht, Karsten; Adamsen, Tom Christian; Biermann, Martin; Brekke, Njål; Craven, Alexander R.; Ersland, Lars; Grüner, Renate; Kleven-Madsen, Nina; Kvernenes, Ole Heine; Schwarzlmüller, Thomas; Olesen, Rasmus Aamand; Hugdahl, Kenneth (Peer reviewed; Journal article, 2015-06)
      Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ...
    • Dynamic switching between intrinsic and extrinsic mode networks as demands change from passive to active processing 

      Riemer, Frank; Gruner, Eli Renate; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Ersland, Lars; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020-12-08)
      In this study we report on the relationship between default and extrinsic mode networks across alternating brief periods of rest and active task processing. Three different visual tasks were used in a classic fMRI ON–OFF ...
    • Dynamic up- and down-regulation of thedefault (DMN) and extrinsic (EMN) modenetworks during alternating task-on and task-offperiods 

      Hugdahl, Kenneth; Kazimierczak, Katarzyna Anna; Beresniewicz, Justyna; Kompus, Kristiina; Westerhausen, René; Ersland, Lars; Grüner, Renate; Specht, Karsten (Peer reviewed; Journal article, 2019)
      Using fMRI, Hugdahl et al. (2015) reported the existence of a general-domain cortical network during active task-processing which was non-specific to the cognitive task being processed. They labelled this network the ...
    • Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function 

      Oltedal, Leif; Kessler, Ute; Ersland, Lars; Grüner, Renate; Andreassen, Ole Andreas; Haavik, Jan; Hoff, Per Ivar; Hammar, Åsa; Dale, Anders Martin; Hugdahl, Kenneth; Ødegaard, Ketil Joachim (Peer reviewed; Journal article, 2015-05-01)
      Background Major depression can be a serious and debilitating condition. For some patients in a treatment resistant depressive episode, electroconvulsive treatment (ECT) is the only treatment that is effective. Although ...
    • Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate 

      Erchinger, Vera Jane; Craven, Alexander R.; Ersland, Lars; Oedegaard, Ketil J.; Bartz-Johannessen, Christoffer; Hammar, Åsa Karin; Haavik, Jan; Riemer, Frank; Kessler, Ute; Oltedal, Leif (Journal article; Peer reviewed, 2023)
      Introduction: Based on previous research on electroconvulsive therapy (ECT) we have proposed a model where disruption, potentiation, and rewiring of brain networks occur in sequence and serve as the underlying therapeutic ...
    • fMRI fluctuations within the language network are correlated with severity of hallucinatory symptoms in schizophrenia 

      Spironelli, Chiara; Marino, Marco; Mantini, Dante; Montalti, Riccardo; Craven, Alexander R.; Ersland, Lars; Angrilli, Alessandro; Hugdahl, Kenneth Jan (Journal article; Peer reviewed, 2023)
      Although schizophrenia (SZ) represents a complex multiform psychiatric disorder, one of its most striking symptoms are auditory verbal hallucinations (AVH). While the neurophysiological origin of this pervasive symptom has ...
    • Frequency drift in MR spectroscopy at 3T 

      Hui, Steve C.N.; Mikkelsen, Mark; Zöllner, Helge J.; Craig-Craven, Alexander Richard; Ersland, Lars; Edden, Richard A.E. (Journal article; Peer reviewed, 2021)
      Purpose Heating of gradient coils and passive shim components is a common cause of instability in the B0 field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical ...
    • GABA, glutamatergic dynamics and BOLD contrast assessed concurrently using functional MRS during a cognitive task 

      Craven, Alexander R.; Dwyer, Gerard Eric; Ersland, Lars; Kazimierczak, Katarzyna Anna; Noeske, Ralph; Sandøy, Lydia Brunvoll; Johnsen, Erik; Hugdahl, Kenneth Jan (Journal article; Peer reviewed, 2023)
      A recurring issue in functional neuroimaging is how to link task-driven haemodynamic blood oxygen level dependent functional MRI (BOLD-fMRI) responses to underlying neurochemistry at the synaptic level. Glutamate and ...
    • Glutamate- and GABA-Modulated Connectivity in Auditory Hallucinations—A Combined Resting State fMRI and MR Spectroscopy Study 

      Weber, Sarah; Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2021)
      Background: Auditory verbal hallucinations (AVH) have been linked to aberrant interhemispheric connectivity between the left and the right superior temporal gyrus (STG), labeled the interhemispheric miscommunication theory. ...
    • Hallucinating schizophrenia patients have longer left arcuate fasciculus fiber tracks: a DTI tractography study 

      Falkenberg, Liv E.; Westerhausen, René; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Kompus, Kristiina; Ersland, Lars; Sandøy, Lydia Brunvoll; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      The arcuate fasciculus (AF) has been implicated in the pathology behind schizophrenia and auditory verbal hallucinations (AVHs). White matter tracts forming the arcuate fasciculus can be quantified and visualized using ...
    • Intra-Regional Glu-GABA vs Inter-Regional Glu-Glu Imbalance: A 1H-MRS Study of the Neurochemistry of Auditory Verbal Hallucinations in Schizophrenia. 

      Hjelmervik, Helene; Craven, Alexander R.; Sinkeviciute, Igne; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Gruner, Eli Renate; Hugdahl, Kenneth (Peer reviewed; Journal article, 2019-10-18)
      Glutamate (Glu), gamma amino-butyric acid (GABA), and excitatory/inhibitory (E/I) imbalance have inconsistently been implicated in the etiology of schizophrenia. Elevated Glu levels in language regions have been suggested ...
    • Magnetic Resonance Spectroscopy in Depressed Subjects Treated With Electroconvulsive Therapy—A Systematic Review of Literature 

      Erchinger, Vera Jane; Ersland, Lars; Aukland, Stein Magnus; Abbott, Christopher; Oltedal, Leif (Journal article; Peer reviewed, 2021)
      Electroconvulsive therapy (ECT) is considered to be the most effective acute treatment for otherwise treatment resistant major depressive episodes, and has been used for over 80 years. Still, the underlying mechanism of ...