Browsing Bergen Open Research Archive by Author "Ewe, Chee Kiang"
Now showing items 1-3 of 3
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Evolution and developmental system drift in the endoderm gene regulatory network of Caenorhabditis and other nematodes
Ewe, Chee Kiang; Torres Cleuren, Yamila Nicole; Rothman, Joel H (Journal article; Peer reviewed, 2020)Developmental gene regulatory networks (GRNs) underpin metazoan embryogenesis and have undergone substantial modification to generate the tremendous variety of animal forms present on Earth today. The nematode Caenorhabditis ... -
Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network
Torres Cleuren, Yamila Nicole; Ewe, Chee Kiang; Chipman, Kyle C; Mears, Emily R; Wood, Cricket G; Al-Alami, Coco Emma Alma; Alcorn, Melissa R; Turner, Thomas L; Joshi, Pradeep M; Snell, Russell G; Rothman, Joel H (Peer reviewed; Journal article, 2019-08-15)Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, ... -
Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways
Flowers, Sagen; Kothari, Rushali; Torres Cleuren, Yamila Nicole; Alcorn, Melissa R.; Ewe, Chee Kiang; Alok, Geneva; Fiallo, Samantha L.; Joshi, Pradeep M.; Rothman, Joel H. (Journal article; Peer reviewed, 2023)The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). ‘Purifying selection’ mechanisms operate to remove such dysfunctional mtDNAs. We found that activators ...