Browsing Bergen Open Research Archive by Author "Fang, Fei"

Now showing items 1-5 of 5

    • Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation 

      Liang, Xiao; Chen, Anbin; Kianian, Atefeh; Kristiansen, Cecilie Katrin; Tsering Yangzom, Tsering Yangzom; Furriol Palmer, Jessica; Høyland, Lena Elise; Ziegler, Mathias; Kråkenes, Torbjørn; Tzoulis, Charalampos; Fang, Fei; Sullivan, Gareth John; Bindoff, Laurence Albert (Journal article; Peer reviewed, 2024)
      Mitochondrial diseases are associated with neuronal death and mtDNA depletion. Astrocytes respond to injury or stimuli and damage to the central nervous system. Neurodegeneration can cause astrocytes to activate and acquire ...

    • Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease 

      Knapskog, Anne Brita; Aksnes, Mari; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Saltvedt, Ingvild Tina; Giil, Lasse Melvær; Watne, Leiv (Journal article; Peer reviewed, 2023)
      Introduction: The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a possible ...

    • Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies 

      Wang, Heling; Siow, Richard; Schmauck-Medina, Tomás Alejandro; Zhang, Jianying; Sandset, Per Morten; Filshie, Clare; Lund, Øystein; Partridge, Linda; Bergersen, Linda Hildegard; Juel Rasmussen, Lene; Palikaras, Konstantinos; Sotiropoulos, Ioannis; Storm-Mathisen, Jon; Rubinsztein, David C.; Spillantini, Maria Grazia; De Zeeuw, Chris I.; Watne, Leiv; Vyhnalek, Martin; Veverova, Katerina; Liang, Xiao; Tavernarakis, Nektarios; Bohr, Vilhelm A.; Yokote, Koutaro; Saarela, Janna Saija; Nilsen, Hilde; Gonos, Efstathios S.; Scheibye-Knudsen, Morten; Chen, Guobing; Kato, Hisaya; Selbæk, Geir; Fladby, Tormod; Nilsson, Per; Simonsen, Anne Gjøen; Aarsland, Dag; Hindkjær Lautrup, Sofie; Ottersen, Ole Petter; Cox, Lynne S.; Fang, Fei (Journal article; Peer reviewed, 2024)
      Unhealthy aging poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the aging process offers a promising approach to reduce the burden of a number of age-related diseases, such ...

    • The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease 

      Hong, Yu; Zhang, Zhuoyuan; Yangzom, Tsering; Chen, Anbin; Lundberg, Bjørn Christian; Fang, Fei; Siller, Richard; Sullivan, Gareth John; Zeman, Jiri; Tzoulis, Charalampos; Bindoff, Laurence Albert; Liang, Xiao (Journal article; Peer reviewed, 2024)
      Alpers' syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase-gamma (POLG), which is essential for mitochondrial DNA ...

    • Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease 

      Knapskog, Anne-Brita; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Solvang, Stein-Erik Hafstad; Saltvedt, Ingvild Tina; Watne, Leiv; Aksnes, Mari (Journal article; Peer reviewed, 2024-07-27)
      Background: Sex differences in neuroinflammation could contribute to women’s increased risk of Alzheimer’s disease (AD), providing rationale for exploring sex-specific AD biomarkers. In AD, dysregulation of the kynurenine ...