Blar i Bergen Open Research Archive på forfatter "Ferrario, Eugenio"
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The balance between NAD+ biosynthesis and consumption in ageing
Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ... -
Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage
Ferrario, Eugenio; Kallio, Juha Pekka; Emdadi, Mahdi; Strømland, Øyvind; Rack, Johannes Gregor M; Ziegler, Mathias (Journal article; Peer reviewed, 2024)Tuberculosis necrotizing toxin (TNT) is a protein domain discovered on the outer membrane of Mycobacterium tuberculosis (Mtb), and the fungal pathogen Aspergillus fumigatus. TNT domains have pure NAD(P) hydrolytic activity, ... -
Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase
Ferrario, Eugenio; Kallio, Juha Pekka; Strømland, Øyvind; Ziegler, Mathias (Journal article; Peer reviewed, 2023)Nicotinamide adenine dinucleotide (NAD) is an essential molecule in all kingdoms of life, mediating energy metabolism and cellular signaling. Recently, a new class of highly active fungal surface NADases was discovered. ...