Browsing Bergen Open Research Archive by Author "Finn, Roderick Nigel"
Now showing items 1-17 of 17
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Aquaporin evolution in fishes
Finn, Roderick Nigel; Cerdà, Joan (Peer reviewed; Journal article, 2011-07-26)Aquaporins represent a primordial group of transmembrane solvent channels that have been documented throughout the living biota. This facet alone emphasizes the positive selection pressure for proteins associated with ... -
Aquaporin splice variation differentially modulates channel function during marine teleost egg hydration
Ferré, Alba; Chauvigné, Francois; Zapater, Cinta; Finn, Roderick Nigel; Cerdà, Joan (Journal article; Peer reviewed, 2023)Aquaporin-mediated oocyte hydration is a developmentally regulated adaptive mechanism that co-occurs with meiosis resumption in marine teleosts. It provides the early embryos with vital water until osmoregulatory systems ... -
Auto-Adhesion Potential of Extraocular Aqp0 during Teleost Development
Chauvigné, Francois; Fjelldal, Per Gunnar; Cerdà, Joan; Finn, Roderick Nigel (Peer reviewed; Journal article, 2016-05-06)AQP0 water channels are the most abundant proteins expressed in the mammalian lens fiber membranes where they are essential for lens development and transparency. Unlike other aquaporin paralogs, mammalian AQP0 has a low ... -
Developmental RNA-Seq transcriptomics of haploid germ cells and spermatozoa uncovers novel pathways associated with teleost spermiogenesis
Castro-Arnau, Júlia; Chauvigné, Francois; Gómez-Garrido, Jessica; Esteve-Codina, Anna; Dabad, Marc; Alioto, Tyler; Finn, Roderick Nigel; Cerdà, Joan (Journal article; Peer reviewed, 2022)In non-mammalian vertebrates, the molecular mechanisms involved in the transformation of haploid germ cells (HGCs) into spermatozoa (spermiogenesis) are largely unknown. Here, we investigated this process in the marine ... -
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
Ferré, Alba; Chauvigné, Francois; Vlasova, Anna; Norberg, Birgitta; Bargelloni, Luca; Guigó, Roderic; Finn, Roderick Nigel; Cerdà, Joan (Journal article; Peer reviewed, 2023)Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this vital process are ... -
Insect glycerol transporters evolved by functional co-option and gene replacement
Finn, Roderick Nigel; Chauvigné, Francois; Stavang, Jon Anders; Belles, Xavier; Cerdà, Joan (Peer reviewed; Journal article, 2015-07-17)Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable ... -
Lineage-level divergence of copepod glycerol transporters and the emergence of isoform-specific trafficking regulation
Catalán-García, Marc; Chauvigné, Francois; Stavang, Jon Anders; Nilsen, Frank; Cerdà, Joan; Finn, Roderick Nigel (Journal article; Peer reviewed, 2021)Transmembrane conductance of small uncharged solutes such as glycerol typically occurs through aquaglyceroporins (Glps), which are commonly encoded by multiple genes in metazoan organisms. To date, however, little is known ... -
The lineage-specific evolution of aquaporin gene clusters facilitated tetrapod terrestrial adaptation
Finn, Roderick Nigel; Chauvigné, Francois; Hlidberg, Jón Baldur; Cutler, Christopher P.; Cerdà, Joan (Peer reviewed; Journal article, 2014-11-26)A major physiological barrier for aquatic organisms adapting to terrestrial life is dessication in the aerial environment. This barrier was nevertheless overcome by the Devonian ancestors of extant Tetrapoda, but the origin ... -
Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility
Chauvigné, François; Boj, Mónica; Finn, Roderick Nigel; Cerdà, Joan (Peer reviewed; Journal article, 2015-01-14)Reactive oxygen species (ROS), particularly hydrogen peroxide (H2O2), cause oxidative cell damage and inhibit sperm function. In most oviparous fishes that spawn in seawater (SW), spermatozoa may be exposed to harmful ROS ... -
Neurohypophysial and paracrine vasopressinergic signaling regulates aquaporin trafficking to hydrate marine teleost oocytes
Ferré, Alba; Chauvigné, Francois; Gozdowska, Magdalena; Kulczykowska, Ewa; Finn, Roderick Nigel; Cerdà, Joan (Journal article; Peer reviewed, 2023)The dual aquaporin (Aqp1ab1/Aqp1ab2)-mediated hydration of marine teleost eggs, which occurs during oocyte meiosis resumption (maturation), is considered a key adaptation underpinning their evolutionary success in the ... -
The pH sensitivity of Aqp0 channels in tetraploid and diploid teleosts
Chauvigné, Francois; Zapater, Cinta; Stavang, Jon Anders; Taranger, Geir Lasse; Cerdà, Joan; Finn, Roderick Nigel (Peer reviewed; Journal article, 2015)Water homeostasis and the structural integrity of the vertebrate lens is partially mediated by AQP0 channels. Emerging evidence indicates that external pH may be involved in channel gating. Here we show that a tetraploid ... -
Phylogenomic and functional analyses of salmon lice aquaporins uncover the molecular diversity of the superfamily in Arthropoda
Stavang, Jon Anders; Chauvigné, Francois; Kongshaug, Heidi; Cerdà, Joan; Nilsen, Frank; Finn, Roderick Nigel (Peer reviewed; Journal article, 2015-08-19)Background An emerging field in biomedical research is focusing on the roles of aquaporin water channels in parasites that cause debilitating or lethal diseases to their vertebrate hosts. The primary vectorial agents are ... -
A transcriptomic analysis of diploid and triploid Atlantic salmon lenses with and without cataracts
Olsvik, Pål Asgeir; Finn, Roderick Nigel; Remø, Sofie C.; Fjelldal, Per Gunnar; Chauvigné, Francois; Glover, Kevin; Hansen, Tom Johnny; Waagbø, Rune (Journal article; Peer reviewed, 2020)To avoid negative environmental impacts of escapees and potential inter-breeding with wild populations, the Atlantic salmon farming industry has and continues to extensively test triploid fish that are sterile. However, ... -
Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters
Yilmaz, Ozlem; Chauvigné, Francois; Ferré, Alba; Nilsen, Frank; Fjelldal, Per Gunnar; Cerdà, Joan; Finn, Roderick Nigel (Journal article; Peer reviewed, 2020)Transmembrane glycerol transport is an ancient biophysical property that evolved in selected subfamilies of water channel (aquaporin) proteins. Here, we conducted broad level genome (>550) and transcriptome (>300) analyses ... -
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter
Chauvigné, Francois; Yilmaz, Ozlem; Ferré, Alba; Fjelldal, Per Gunnar; Finn, Roderick Nigel; Cerdà, Joan (Peer reviewed; Journal article, 2019-12-11)Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in ... -
Vertebrate Vitellogenin Gene Duplication in Relation to the ‘‘3R Hypothesis’’: Correlation to the Pelagic Egg and the Oceanic Radiation of Teleosts
Finn, Roderick Nigel; Kristoffersen, Børge André (Peer reviewed; Journal article, 2007)The spiny ray-finned teleost fishes (Acanthomorpha) are the most successful group of vertebrates in terms of species diversity. Their meteoric radiation and speciation in the oceans during the late Cretaceous and Eocene ... -
The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate specificities similar to mammals
Tingaud-Sequeira, Angèle; Calusinska, Magdalena; Finn, Roderick Nigel; Chauvigné, François; Lozano, Juanjo; Cerdà, Joan (Peer reviewed; Journal article, 2010-02-11)Background: Aquaporins are integral membrane proteins that facilitate the transport of water and small solutes across cell membranes. These proteins are vital for maintaining water homeostasis in living organisms. In ...