Browsing Bergen Open Research Archive by Author "Finne, Kenneth"

Now showing items 1-9 of 9

    • Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli 

      Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine Maria; Osman, Tarig Al-Hadi; Marti, Hans-Peter; Berven, Frode; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2019-11-14)
      Background IgA nephropathy (IgAN) involves mesangial matrix expansion, but the proteomic composition of this matrix is unknown. The present study aimed to characterize changes in extracellular matrix in IgAN. Methods In ...

    • Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis 

      Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter (Peer reviewed; Journal article, 2017)
      Clear cell renal cell carcinoma (ccRCC) represents the most common type of kidney cancer with high mortality in its advanced stages. Our study aim was to explore the correlation between tumor epithelial-to-mesenchymal ...

    • Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy 

      Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine Maria; Marti, Hans-Peter; Mollnes, Tom Eirik; Berven, Frode; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2017-08-14)
      Background: The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with ...

    • Hypoxia induced responses are reflected in the stromal proteome of breast cancer 

      Kjølle, Silje; Finne, Kenneth; Birkeland, Even; Ardawatia, Vandana; Winge, Ingeborg; Aziz, Sura Mohammed; Knutsvik, Gøril; Wik, Elisabeth; Paulo, Joao A.; Vethe, Heidrun; Kleftogiannis, Dimitrios; Akslen, Lars Andreas (Journal article; Peer reviewed, 2023)
      Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) ...

    • A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer 

      Ingebriktsen, Lise Martine; Finne, Kenneth; Akslen, Lars Andreas; Wik, Elisabeth (Journal article; Peer reviewed, 2022)
      Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC ...

    • Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats 

      Finne, Kenneth; Vethe, Heidrun; Skogstrand, Trude; Leh, Sabine Maria; Dahl, Tone Dolva; Tenstad, Olav; Berven, Frode S.; Reed, Rolf K.; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2014-08-16)
      Background It is well known that hypertension may cause glomerular damage, but the molecular mechanisms involved are still incompletely understood. Methods In the present study, we used formalin-fixed paraffin-embedded ...

    • Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN 

      Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine; Marti, Hans Peter; Berven, Frode Steingrimsen; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2022-03-24)
      Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ...

    • Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups 

      Askeland, Cecilie; Wik, Elisabeth; Finne, Kenneth; Birkeland, Even; Arnes, Jarle; Collett, Karin; Knutsvik, Gøril; Krüger, Kristi; Davidsen, Benedicte; Aas, Turid; Eide, Geir Egil; Stefansson, Ingunn; Foulkes, William; Akslen, Lars A. (Journal article; Peer reviewed, 2020)
      Studies indicate that stathmin expression associates with PI3K activation in breast cancer, suggesting stathmin as a marker for targetable patient subgroups. Here we assessed stathmin in relation to tumour proliferation, ...

    • VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats 

      Samuelsson, Anne-Maj; Bartolomaeus, Theda Ulrike Patricia; Anandakumar, Harithaa; Thowsen, Irene Matre; Nikpey, Elham; Han, Jianhua; Marko, Lajos; Finne, Kenneth; Tenstad, Olav; Eckstein, Johannes; Berndt, Nikolaus; Kühne, Titus; Kedziora, Sarah; Sultan, Ibrahim; Skogstrand, Trude; Karlsen, Tine Veronica; Nurmi, Harri; Forslund, Sofia K.; Bollano, Entela; Alitalo, Kari; Muller, Dominik N.; Wiig, Helge (Journal article; Peer reviewed, 2023)
      Aims: Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial ...