• Algal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometry 

      Hjørnevik, Linda Veka; Frøyset, Ann Kristin; Grønset, Toril Anne; Rungruangsak-Torrissen, Krisna; Fladmark, Kari Espolin (Peer reviewed; Journal article, 2015-12-14)
      Azaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and ...
    • Comprehensive Analysis of Exported Proteins from Mycobacterium tuberculosis H37Rv 

      Målen, Hiwa; Berven, Frode S.; Fladmark, Kari Espolin; Wiker, Harald G. (Proteomics, Peer reviewed; Journal article, 2007-04-21)
      Proteins secreted by Mycobacterium tuberculosis play an essential role in the pathogenesis of tuberculosis. The culture filtrates of M. tuberculosis H37Rv made by Sadamu Nagai (Japan), are considerably enriched for secreted ...
    • Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid 

      Opsahl, Jill Anette; Ljostveit, Sonja; Saunders, Threrese Solstad; Risa, Kristin; Roepstorff, Peter; Fladmark, Kari Espolin (Peer reviewed; Journal article, 2013)
      Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact. When cells are exposed to high concentrations of okadaic ...
    • The N-terminal acetyltransferase Naa10 is essential for zebrafish development 

      Ree, Rasmus Moen; Myklebust, Line Merethe; Thiel, Puja; Foyn, Håvard; Fladmark, Kari Espolin; Arnesen, Thomas (Peer reviewed; Journal article, 2015-08-06)
      N-terminal acetylation, catalysed by N-terminal acetyltransferases (NATs), is among the most common protein modifications in eukaryotes and involves the transfer of an acetyl group from acetyl-CoA to the α-amino group of ...
    • Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA) 

      Frøyset, Ann Kristin; Khan, Essa Ahsan; Fladmark, Kari Espolin (Peer reviewed; Journal article, 2016-07-12)
      The non-protein amino acid β-methylamino-L-alanine (BMAA) is a neurotoxin present in microalgae and shown to accumulate in the food web. BMAA has been linked to the complex neurodegenerative disorder of Guam and to increased ...
    • Redox control of protein degradation 

      Pajares, Marta; Jiménez-Moreno, Natalia; Dias, Irundika H.K.; Debelec, Bilge; Vucetic, Milica; Fladmark, Kari Espolin; Basaga, Huveyda; Ribaric, Samo; Milisav, Irina; Cuadrado, Antonio (Peer reviewed; Journal article, 2015-12)
      Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well ...