Browsing Bergen Open Research Archive by Author "Fladmark, Kari Espolin"

Now showing items 1-10 of 10

    • Accelerated Sarcopenia Phenotype in the DJ-1/Park7-Knockout Zebrafish 

      Rostad, Kristine Ovidia; Trognitz, Tobias; Frøyset, Ann Kristin; Bifulco, Ersilia; Fladmark, Kari Espolin (Journal article; Peer reviewed, 2024)
      Age-dependent loss of muscle mass and function is associated with oxidative stress. DJ-1/Park7 acts as an antioxidant through multiple signalling pathways. DJ-1-knockout zebrafish show a decline in swimming performance and ...

    • Algal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometry 

      Hjørnevik, Linda Veka; Frøyset, Ann Kristin; Grønset, Toril Anne; Rungruangsak-Torrissen, Krisna; Fladmark, Kari Espolin (Peer reviewed; Journal article, 2015-12-14)
      Azaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and ...

    • Comprehensive Analysis of Exported Proteins from Mycobacterium tuberculosis H37Rv 

      Målen, Hiwa; Berven, Frode S.; Fladmark, Kari Espolin; Wiker, Harald G. (Proteomics, Peer reviewed; Journal article, 2007-04-21)
      Proteins secreted by Mycobacterium tuberculosis play an essential role in the pathogenesis of tuberculosis. The culture filtrates of M. tuberculosis H37Rv made by Sadamu Nagai (Japan), are considerably enriched for secreted ...

    • Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid 

      Opsahl, Jill Anette; Ljostveit, Sonja; Saunders, Threrese Solstad; Risa, Kristin; Roepstorff, Peter; Fladmark, Kari Espolin (Peer reviewed; Journal article, 2013)
      Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact. When cells are exposed to high concentrations of okadaic ...

    • Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation 

      Førde, Jan-Lukas; Alhourani, Abdelnour; Carey, Tian; Arbab, Adrees; Fladmark, Kari Espolin; Skrede, Silje; Mollnes, Tom Eirik; Herfindal, Lars; Hagland, Hanne Røland (Journal article; Peer reviewed, 2024)
      Graphene, a material composed of a two-dimensional lattice of carbon atoms, has due to its many unique properties a wide array of potential applications in the biomedical field. One of the most common production methods ...

    • The N-terminal acetyltransferase Naa10 is essential for zebrafish development 

      Ree, Rasmus Moen; Myklebust, Line Merethe; Thiel, Puja; Foyn, Håvard; Fladmark, Kari Espolin; Arnesen, Thomas (Peer reviewed; Journal article, 2015-08-06)
      N-terminal acetylation, catalysed by N-terminal acetyltransferases (NATs), is among the most common protein modifications in eukaryotes and involves the transfer of an acetyl group from acetyl-CoA to the α-amino group of ...

    • A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae 

      Førde, Jan-Lukas; Reiten, Ingeborg Nerbø; Fladmark, Kari Espolin; Kittang, Astrid Marta Olsnes; Herfindal, Lars (Journal article; Peer reviewed, 2022)
      Acute myeloid leukemia and myelodysplastic syndromes are cancers of the bone marrow with poor prognosis in frail and older patients. To investigate cancer pathophysiology and therapies, confocal imaging of fluorescent ...

    • Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish 

      Chavali, Lakshmi Narasimha Murthy; Yddal, Ingeborg; Bifulco, Ersilia; Mannsåker, Simen; Røise, Dagne; Law, Jack Owen; Frøyset, Ann Kristin; Grellscheid, Sushma Nagaraja; Fladmark, Kari Espolin (Journal article; Peer reviewed, 2023)
      DJ-1 is a redox sensitive protein with a wide range of functions related to oxidative stress protection. Mutations in the park7 gene, which codes for DJ-1 are associated with early onset familial Parkinson’s disease and ...

    • Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA) 

      Frøyset, Ann Kristin; Khan, Essa Ahsan; Fladmark, Kari Espolin (Peer reviewed; Journal article, 2016-07-12)
      The non-protein amino acid β-methylamino-L-alanine (BMAA) is a neurotoxin present in microalgae and shown to accumulate in the food web. BMAA has been linked to the complex neurodegenerative disorder of Guam and to increased ...

    • Redox control of protein degradation 

      Pajares, Marta; Jiménez-Moreno, Natalia; Dias, Irundika H.K.; Debelec, Bilge; Vucetic, Milica; Fladmark, Kari Espolin; Basaga, Huveyda; Ribaric, Samo; Milisav, Irina; Cuadrado, Antonio (Peer reviewed; Journal article, 2015-12)
      Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well ...