Browsing Bergen Open Research Archive by Author "Fogg, Deryn Elizabeth"
Now showing items 1-9 of 9
-
Anionic Olefin Metathesis Catalysts Enable Modification of Unprotected Biomolecules in Water
Blanco, Christian O.; Ramos Castellanos, Richard; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2024)Stability problems have limited the uptake of cationic olefin metathesis catalysts in chemical biology. Described herein are anionic catalysts that improve water-solubility, robustness, and compatibility with biomolecules ... -
Bimolecular Coupling in Olefin Metathesis: Correlating Structure and Decomposition for Leading and Emerging Ruthenium−Carbene Catalysts
Nascimento, Daniel L.; Foscato, Marco; Occhipinti, Giovanni; Jensen, Vidar Remi; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2021)Bimolecular catalyst decomposition is a fundamental, long-standing challenge in olefin metathesis. Emerging ruthenium–cyclic(alkyl)(amino)carbene (CAAC) catalysts, which enable breakthrough advances in productivity and ... -
Challenging Metathesis Catalysts with Nucleophiles and Brønsted Base: Examining the Stability of State-of-the-Art Ruthenium Carbene Catalysts to Attack by Amines
do Nascimento, Daniel Luis; Reim, Immanuel; Foscato, Marco; Jensen, Vidar Remi; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2020)Critical to advancing the uptake of olefin metathesis in leadingcontexts, including pharmaceutical manufacturing, is identification of highlyactive catalysts that resist decomposition. Amines constitute an aggressivechallenge ... -
The Impact of Water on Ru-Catalyzed Olefin Metathesis: Potent Deactivating Effects Even at Low Water Concentrations
Blanco, Christian O.; Sims, Joshua; Nascimento, Daniel L.; Goudreault, Alexandre Y.; Steinmann, Stephan N.; Michel, Carine; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2021)Ruthenium catalysts for olefin metathesis are widely viewed as water-tolerant. Evidence is presented, however, that even low concentrations of water cause catalyst decomposition, severely degrading yields. Of 11 catalysts ... -
The Janus face of high trans-effect carbenes in olefin metathesis: gateway to both productivity and decomposition
Occhipinti, Giovanni; Nascimento, Daniel L.; Foscato, Marco; Fogg, Deryn Elizabeth; Jensen, Vidar Remi (Journal article; Peer reviewed, 2022)Ruthenium–cyclic(alkyl)(amino)carbene (CAAC) catalysts, used at ppm levels, can enable dramatically higher productivities in olefin metathesis than their N-heterocyclic carbene (NHC) predecessors. A key reason is the reduced ... -
Mesomeric Acceleration Counters Slow Initiation of Ruthenium-CAAC Catalysts for Olefin Metathesis (CAAC = Cyclic (Alkyl)(Amino) Carbene)
Ou, Xinrui; Occhipinti, Giovanni; Boisvert, Eliza-Jayne Y.; Jensen, Vidar Remi; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2023)Ruthenium catalysts bearing cyclic (alkyl)(amino)carbene (CAAC) ligands can attain very high productivities in olefin metathesis, owing to their resistance to unimolecular decomposition. Because the propagating methylidene ... -
Probing Catalyst Degradation in Metathesis of Internal Olefins: Expanding Access to Amine-Tagged ROMP Polymers
Cormier, Samantha K.; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2023)Ruthenium-promoted ring-opening metathesis polymerization (ROMP) offers potentially powerful routes to amine-functionalized polymers with antimicrobial, adhesive, and self-healing properties. However, amines readily degrade ... -
Routes to High-Performing Ruthenium–Iodide Catalysts for Olefin Metathesis: Ligand Lability Is Key to Efficient Halide Exchange
Blanco, Christian O.; Nascimento, Daniel L.; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2021)Clean, high-yielding routes are described to ruthenium–diiodide catalysts that were recently shown to enable high productivity in olefin metathesis. For the second-generation Grubbs and Hoveyda catalysts (GII: RuCl2(H2IM ... -
Water-Accelerated Decomposition of Olefin Metathesis Catalysts
Blanco, Christian O.; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2023)Water is ubiquitous in olefin metathesis, at levels ranging from contaminant to cosolvent. It is also non-benign. Water-promoted catalyst decomposition competes with metathesis, even for “robust” ruthenium catalysts. ...