Browsing Bergen Open Research Archive by Author "García de Jalón, Elvira"

Now showing items 1-4 of 4

    • Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model 

      García de Jalón, Elvira; Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; Bjørge, Line; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)
      Purpose Fluorescence imaging (FLI) using targeted near-infrared (NIR) conjugates aids the detection of tumour lesions pre- and intraoperatively. The optimisation of tumour visualisation and contrast is essential and can ...

    • CytoCy5S™, a compound of many structures. in vitro and in vivo evaluation of four near-infrared fluorescent substrates of nitroreductase (NTR) 

      García de Jalón, Elvira; Ruiz de Garibay, Gorka; Haug, Bengt Erik; Mccormack, Emmet Matin (Journal article; Peer reviewed, 2021)
      CytoCy5S™, a quenched, red-shifted fluorescent probe, has been used to exploit the imaging potential of the nitroreductase (NTR) reporter gene platform. Its use has been reported in a number of publications, however there ...

    • Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16 

      Casey, Nicholas Paul; Kleinmanns, Katrin; Forcados, Christopher; Gelebart, Pascal Francois; Joaquina, Sandy; Lode, Martine Rott; Benard, Emmanuelle; Kaveh, Fatemeh; Caulier, Benjamin William; Gjerde, Christiane Helgestad; García de Jalón, Elvira; Warren, David; Lindemann, Kristina Yvonne Kathe; Rokkones, Erik; Davidson, Ben; Myhre, Marit; Kvalheim, Gunnar; Bjørge, Line; Mc Cormack, Emmet; Inderberg, Else Marit; Wälchli, Sébastien (Journal article; Peer reviewed, 2024)
      Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, ...

    • Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy 

      Ruiz de Garibay, Gorka; García de Jalón, Elvira; Stigen, Endre; Lund, Kjetil B.; Popa, Mihaela-Lucia; Davidson, Ben; Mayoral Safont, Mireia; Rygh, Cecilie Brekke; Espedal, Heidi; Barrett, Torill; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)
      Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene ...