• AXL is a driver of stemness in normal mammary gland and breast cancer 

      Engelsen, Agnete; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien; Vatter, Fanny A. Pelissier; Tiron, Crina Elena; Villadsen, René; Miyano, Masaru; Lotsberg, Maria Lie; Madeleine, Noëlly; Panahandeh, Pouda; Dhakal, Sushil; Tan, Tuan Zea; Peters, Stacey D'Mello; Grøndal, Sturla Magnus; Aziz, Sura Mohammed; Nord, Silje; Herfindal, Lars; Stampfer, Martha R.; Sørlie, Therese; Brekken, Rolf A; Straume, Oddbjørn; Halberg, Nils; Gausdal, Gro; Thiery, Jean Paul; Akslen, Lars A.; Petersen, Ole W.; LaBarge, Mark A.; Lorens, James (Journal article; Peer reviewed, 2020)
      The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ...
    • AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells 

      Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane; Tan, Tuan Zea; Lu, Ning; Trachsel-Moncho, Laura; Røsland, Gro Vatne; Siraji, Muntequa Ishtiaq; Hellesøy, Monica; Rayford, Austin James; Jacobsen, Kirstine; Ditzel, Henrik J; Vintermyr, Olav Karsten; Bivona, Trever G; Minna, John; Brekken, Rolf A; Baguley, Bruce; Micklem, David; Akslen, Lars A.; Gausdal, Gro; Simonsen, Anne; Thiery, Jean Paul; Chouaib, Salem; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2020)
      Introduction Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine ...
    • AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction 

      Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)
      The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ...
    • Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model 

      Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)
      Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ...
    • Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis 

      Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter (Peer reviewed; Journal article, 2017)
      Clear cell renal cell carcinoma (ccRCC) represents the most common type of kidney cancer with high mortality in its advanced stages. Our study aim was to explore the correlation between tumor epithelial-to-mesenchymal ...
    • Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis 

      Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frédéric; Rouhee, Nazanin; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Døskeland, Stein Ove (Peer reviewed; Journal article, 2013)
      We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect ...
    • Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen 

      Herfindal, Lars; Myhren, Lene Elisabeth; Gjertsen, Bjørn Tore; Døskeland, Stein Ove; Gausdal, Gro (Peer reviewed; Journal article, 2013-07-11)
      Background: The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline ...
    • A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target 

      Tutusaus, Anna; de Gregorio, Estefanía; Cucarull, Blanca; Cristóbal, Helena; Aresté, Cristina; Graupera, Isabel; Coll, Mar; Colell, Anna; Gausdal, Gro; Lorens, James; García de Frutos, Pablo; Morales, Albert; Marí, Montserrat (Peer reviewed; Journal article, 2019)
      Background and Aims GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) ...
    • Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells 

      Myhren, Lene Elisabeth; Nygård, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Døskeland, Stein Ove; Selheim, Frode; Herfindal, Lars (Peer reviewed; Journal article, 2013-01-30)
      Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ...
    • New lessons from an “old” drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia 

      Gausdal, Gro (Doctoral thesis, 2007-12-18)
      Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogenous leukemia (AML). Even though the mechanism of action of anthracyclines has been extensively studied over the years, ...