Browsing Bergen Open Research Archive by Author "Gjerdevik, Miriam"
Now showing items 1-16 of 16
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Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma
Gagnat, Ane Aamli; Gjerdevik, Miriam; Lie, Stein Atle; Gulsvik, Amund; Bakke, Per S.; Nielsen, Rune (Journal article; Peer reviewed, 2020)Rationale There is limited knowledge on the effect of acute exacerbations in chronic obstructive pulmonary disease (AECOPD) on lung cancer risk in COPD patients with and without a history of asthma. This study aims to ... -
Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with DMD, FGF13, EGFL6, and Additional Loci at Xp22.2
Skare, Øivind; Lie, Rolv T.; Haaland, Øystein Ariansen; Gjerdevik, Miriam; Romanowska, Julia; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-22)Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These parent-of-origin (PoO) effects have not yet been explored on the X chromosome, which ... -
Design efficiency in genetic association studies
Gjerdevik, Miriam; Gjessing, Håkon K.; Romanowska, Julia; Haaland, Øystein Ariansen; Jugessur, Astanand; Czajkowski, Nikolai Olavi; Lie, Rolv T. (Journal article; Peer reviewed, 2020)Selecting the best design for genetic association studies requires careful deliberation; different study designs can be used to scan for different genetic effects, and each design has its own set of strengths and limitations. ... -
Family-based genetic association models
Gjerdevik, Miriam (Doctoral thesis, 2020-06-15)The high heritability and recurrence rates observed for several complex diseases justify the search for genetic risk factors. However, despite decades of intense and extensive research, the underlying genetic basis of most ... -
Gene-methylation interactions: Discovering region-wise DNA methylation levels that modify SNP-associated disease risk
Romanowska, Julia; Haaland, Øystein Ariansen; Jugessur, Astanand; Gjerdevik, Miriam; Xu, Zongli; Taylor, Jack A.; Wilcox, Allen J; Jonassen, Inge; Lie, Rolv T.; Gjessing, Håkon K. (Journal article; Peer reviewed, 2020)Background Current technology allows rapid assessment of DNA sequences and methylation levels at a single-site resolution for hundreds of thousands of sites in the human genome, in thousands of individuals simultaneously. ... -
Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios
Haaland, Øystein Ariansen; Jugessur, Astanand; Gjerdevik, Miriam; Romanowska, Julia; Shi, Min; Beaty, Terri H.; Marazita, Mary L.; Murray, Jeffrey C.; Wilcox, Allen J.; Lie, Rolv T.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2017-09-12)Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease ... -
A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption
Haaland, Øystein Ariansen; Romanowska, Julia; Gjerdevik, Miriam; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2019-06-24)Background: Although both genetic and environmental factors have been reported to influence the risk of isolated cleft lip with or without cleft palate (CL/P), the exact mechanisms behind CL/P are still largely unaccounted ... -
A genome-wide search for gene-environment effects in isolated cleft lip with or without cleft palate triads points to an interaction between maternal periconceptional vitamin use and variants in ESRRG
Haaland, Øystein Ariansen; Lie, Rolv T.; Romanowska, Julia; Gjerdevik, Miriam; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-26)Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these ... -
Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls
Gjerdevik, Miriam; Jugessur, Astanand; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Cordell, Heather J.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2019-04-02)Background: Log-linear and multinomial modeling offer a flexible framework for genetic association analyses of offspring (child), parent-of-origin and maternal effects, based on genotype data from a variety of child-parent ... -
Improving the error rates of the Begg and Mazumdar test for publication bias in fixed effects meta-analysis
Gjerdevik, Miriam; Heuch, Ivar (Peer reviewed; Journal article, 2014-09-22)Background: The rank correlation test introduced by Begg and Mazumdar is extensively used in meta-analysis to test for publication bias in clinical and epidemiological studies. It is based on correlating the standardized ... -
Isolated oral clefts and school grades: population-based cohort study from Norway
Gjerdevik, Miriam; Lie, Rolv T.; Haaland, Øystein Ariansen; Berg, Erik; Feragen, Kristin Billaud; Sivertsen, Åse (Journal article; Peer reviewed, 2021)Objective To compare school grades of adolescents in Norway born with isolated cleft with those of their unaffected peers. Design Population-based cohort study. Setting Norway. Patients A total of 347 419 individuals ... -
A new approach to chromosome-wide analysis of X-linked markers identifies new associations in Asian and European case-parent triads of orofacial clefts
Skare, Øivind; Gjessing, Håkon K.; Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand (Peer reviewed; Journal article, 2017-09-06)Background: GWAS discoveries on the X-chromosome are underrepresented in the literature primarily because the analytical tools that have been applied were originally designed for autosomal markers. Our objective here is ... -
Parent-of-origin-environment interactions in case-parent triads with or without independent controls
Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand; Gjessing, Håkon K. (Peer reviewed; Journal article, 2018-03)With case–parent triad data, one can frequently deduce parent of origin of the child's alleles. This allows a parent‐of‐origin (PoO) effect to be estimated as the ratio of relative risks associated with the alleles inherited ... -
Statistical methods to detect mother-father genetic interaction effects on risk of infertility: A genome-wide approach
Skodvin, Siri Nærland; Gjessing, Håkon Kristian; Jugessur, Astanand; Romanowska, Julia; Page, Christian Magnus; Corfield, Elizabeth Claire; Lee, Yunsung; Håberg, Siri Eldevik; Gjerdevik, Miriam (Journal article; Peer reviewed, 2023)Infertility is a heterogeneous phenotype, and for many couples, the causes of fertility problems remain unknown. One understudied hypothesis is that allelic interactions between the genotypes of the two parents may influence ... -
Testmetoder for identifisering av publikasjonsbias i metaanalyser
Gjerdevik, Miriam (Master thesis, 2012-10-24)Testmetoder for identifisering av publikasjonsbias i metaanalyser. -
The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome?
Romanowska, Julia; Nustad, Haakon Egdetveit; Page, Christian Magnus; Denault, William Robert Paul; Lee, Yunsung; Magnus, Maria Christine; Haftorn, Kristine Løkås; Gjerdevik, Miriam; Novakovic, Boris; Saffery, Richard; Gjessing, Håkon K.; lyle, robert; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand (Journal article; Peer reviewed, 2023)Background Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated ...