Browsing Bergen Open Research Archive by Author "Glastad, Robert Clay"
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Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck
Edwards, David; Røyrvik, Ellen Christine; Chustecki, Joanne; Giannakis, Konstantinos; Glastad, Robert Clay; Radzvilavicius, Arunas; Johnston, Iain (Journal article; Peer reviewed, 2021)Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic “bottleneck” ... -
\lambda Polarization in Heavy Ion Collisions
Glastad, Robert Clay (Master thesis, 2015-06-02)Results on transverse lambda polarization in peripheral heavy ion collisions in an exact, analytic, self-similar rotating hydrodynamics model using the gradient and curl of the inverse temperature field. We estimate the ... -
Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
Bjune, Mona Synnøve; Dyer, Laurence; Laupsa-Borge, Johnny; Sommersten, Cathrine Horn; McCann, Adrian; Glastad, Robert Clay; Johnston, Iain; Kern, Matthias; Blüher, Matthias; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2023)Background: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated ... -
Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions
Glastad, Robert Clay; Johnston, Iain (Journal article; Peer reviewed, 2023)Mitochondria are highly dynamic organelles, containing vital populations of mitochondrial DNA (mtDNA) distributed throughout the cell. Mitochondria form diverse physical structures in different cells, from cell-wide ...