Blar i Bergen Open Research Archive på forfatter "Govasli Larsen, Morten Andreas"
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Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization
Jakubec, Martin; Bariås, Espen; Furse, Samuel Robert; Govasli Larsen, Morten Andreas; George, Vinnit; Turcu, Diana Cornelia; Iashchishyn, Igor A.; Morozova-Roche, Ludmilla A.; Halskau, Øyvind (Journal article; Peer reviewed, 2021)Dysregulation of the biosynthesis of cholesterol and other lipids has been implicated in many neurological diseases, including Parkinson's disease. Misfolding of α-synuclein (α-Syn), the main actor in Parkinson's disease, ... -
Development of an enterotoxigenic Escherichia colivaccine based on the heat-stable toxin
Zegeye, Ephrem Debebe; Govasli Larsen, Morten Andreas; Sommerfelt, Halvor; Puntervoll, Pål (Peer reviewed; Journal article, 2018)Infection with enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea-related illness and death among children under 5 years of age in low– and middle-income countries (LMIC). Recent studies have found ... -
Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles
Dobrovolska, Olena; Strømland, Øyvind; Handegård, Ørjan Sele; Jakubec, Martin; Govasli Larsen, Morten Andreas; Skjevik, Åge Aleksander; Frøystein, Nils Åge; Teigen, Knut; Halskau, Øyvind (Journal article; Peer reviewed, 2021)The driving forces and conformational pathways leading to amphitropic protein-membrane binding and in some cases also to protein misfolding and aggregation is the subject of intensive research. In this study, a chimeric ... -
Virus-like particle-display of the enterotoxigenic Escherichia coli heat-stable toxoid STh-A14T elicits neutralizing antibodies in mice
Govasli Larsen, Morten Andreas; Diaz, Yuleima; Puntervoll, Pål (Peer reviewed; Journal article, 2019-09-09)Enterotoxigenic Escherichia coli (ETEC) causes diarrhoea by secreting enterotoxins into the small intestine. Human ETEC strains may secrete any combination of three enterotoxins: the heat-labile toxin (LT) and the heat-stable ...