Blar i Bergen Open Research Archive på forfatter "Gravdal, Karsten"
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The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Mannelqvist, Monica; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2021)The prognostic importance of transcription factors promoting epithelial–mesenchymal transition (EMT) and angiogenesis has not been well explored in prostate cancer patients with long follow-up, nor the interplay between ... -
FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Beisland, Christian; Akslen, Lars A.; Halvorsen, Ole Johan (Peer reviewed; Journal article, 2019)Epithelial–mesenchymal transition (EMT) is important for tumour cell invasion and metastasis and is a feature of aggressive carcinomas. EMT is characterised by reduced E‐cadherin and increased N‐cadherin expression ... -
Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer
Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ... -
A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary prostate biopsy
Nygård, Yngve; Haukaas, Svein A.; Halvorsen, Ole J.; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian (Peer reviewed; Journal article, 2016-07-08)Background: The standard of care in patients with suspected prostate cancer (PCa) is systematic prostate biopsies. This approach leads to unnecessary biopsies in patients without PCa and also to the detection of clinical ... -
Transitioning from transrectal to transperineal prostate biopsy using a freehand cognitive approach
Honore, Alfred; Moen, Christian Arvei; Juliebø-Jones, Patrick; Reisæter, Lars Anders Rokne; Gravdal, Karsten; Chaudhry, Adeel Asghar; Rawal, Ravi; Sandøy, Andrine; Beisland, Christian (Journal article; Peer reviewed, 2024)Objectives To report a single-centre experience of a complete transition from transrectal (TR) to transperineal (TP) prostate biopsy under local anaesthesia using a freehand cognitive coaxial approach and without use ...