Browsing Bergen Open Research Archive by Author "Grellscheid, Sushma Nagaraja"

Now showing items 1-8 of 8

    • A bending rigidity parameter for stress granule condensates 

      Law, Jack Owen; Jones, Carl Matthew; Stevenson, Thomas; Williamson, Thomas A.; Turner, Matthew S.; Kusumaatmaja, Halim; Grellscheid, Sushma Nagaraja (Journal article; Peer reviewed, 2023)
      Interfacial tension plays an important role in governing the dynamics of droplet coalescence and determining how condensates interact with and deform lipid membranes and biological filaments. We demonstrate that an interfacial ...

    • Deep conservation of ribosome stall sites across RNA processing genes 

      Chyzynska, Katarzyna; Labun, Kornel; Jones, Carl Matthew; Grellscheid, Sushma Nagaraja; Valen, Eivind Dale (Journal article; Peer reviewed, 2021)
      The rate of translation can vary depending on the mRNA template. During the elongation phase the ribosome can transiently pause or permanently stall. A pause can provide the nascent protein with the time to fold or be ...

    • FAIR+E pathogen data for surveillance and research: lessons from COVID-19 

      Neves, Aitana; Cuesta, Isabel; Hjerde, Erik; Klemetsen, Terje; Salgado, David; van Helden, Jacques; Rahman, Nadim; Fatima, Nazeefa; Karathanasis, Nestoras; Zmora, Pawel; Åkerström, Wolmar Nyberg; Grellscheid, Sushma Nagaraja; Waheed, Zahra; Blomberg, Niklas (Journal article; Peer reviewed, 2023)
      The COVID-19 pandemic has exemplified the importance of interoperable and equitable data sharing for global surveillance and to support research. While many challenges could be overcome, at least in some countries, many ...

    • Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner 

      Lagnado, Anthony; Leslie, Jack; Ruchaud-Sparagano, Marie-Helene; Victorelli, Stella; Hirsova, Petra; Ogrodnik, Mikolaj; Collins, Amy L; Vizioli, Maria Grazia; Habiballa, Leena; Saretzki, Gabriele; Evans, Shane A; Salmonowicz, Hanna; Hruby, Adam; Geh, Daniel; Pavelko, Kevin D; Dolan, David William Peter; Reeves, Helen L; Grellscheid, Sushma Nagaraja; Wilson, Colin H; Pandanaboyana, Sanjay; Doolittle, Madison; von Zglinicki, Thomas; Oakley, Fiona; Gallage, Suchira; Wilson, Caroline L; Birch, Jodie; Carroll, Bernadette; Chapman, James; Heikenwalder, Mathias; Neretti, Nicola; Khosla, Sundeep; Masuda, Claudio Akio; Tchkonia, Tamar; Kirkland, James L; Jurk, Diana; Mann, Derek A.; Passos, João F (Journal article; Peer reviewed, 2021)
      Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro-inflammatory phenotype, thought to contribute to aging and age-related diseases. Neutrophils have essential roles in inflammatory ...

    • Particle detection and tracking with DNA 

      O’Hare, Ciaran A. J.; Matsos, Vassili G.; Newton, Joseph; Smith, Karl; Hochstetter, Joel; Jaiswar, Ravi; Kyaw, Wunna; McNamara, Aimee; Kuncic, Zdenka; Grellscheid, Sushma Nagaraja; Bœhm, Céline (Journal article; Peer reviewed, 2022)
      We present the first proof-of-concept simulations of detectors using biomaterials to detect particle interactions. The essential idea behind a “DNA detector” involves the attachment of a forest of precisely-sequenced single ...

    • Peptide-Based Coacervate-Core Vesicles with Semipermeable Membranes 

      Abbas, Manzar; Law, Jack Owen; Grellscheid, Sushma Nagaraja; Huck, Wilhelm T. S.; Spruijt, Evan (Journal article; Peer reviewed, 2022)
      Coacervates droplets have long been considered as potential protocells to mimic living cells. However, these droplets lack a membrane and are prone to coalescence, limiting their ability to survive, interact, and organize ...

    • Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish 

      Chavali, Lakshmi Narasimha Murthy; Yddal, Ingeborg; Bifulco, Ersilia; Mannsåker, Simen; Røise, Dagne; Law, Jack Owen; Frøyset, Ann Kristin; Grellscheid, Sushma Nagaraja; Fladmark, Kari Espolin (Journal article; Peer reviewed, 2023)
      DJ-1 is a redox sensitive protein with a wide range of functions related to oxidative stress protection. Mutations in the park7 gene, which codes for DJ-1 are associated with early onset familial Parkinson’s disease and ...

    • PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects 

      Atkinson, Robert; Georgiou, Maria; Yang, Chunbo; Szymanska, Katarzyna; Lahat, Albert; Vasconcelos, Elton J. R.; Ji, Yanlong; Moya Molina, Marina; Collin, Joseph; Queen, Rachel; Dorgau, Birthe; Watson, Avril; Kurzawa-Akanbi, Marzena; Laws, Ross; Saxena, Abhijit; Shyan Beh, Chia; Siachisumo, Chileleko; Görtler, Franziska Stilla Maria; Karwatka, Magdalena; Davey, Tracey; Inglehearn, Chris F.; McKibbin, Martin; Lührmann, Reinhard; Steel, David H.; Elliott, David J.; Armstrong, Lyle; Urlaub, Henning; Ali, Robin R.; Grellscheid, Sushma Nagaraja; Johnson, Colin A.; Mozaffari-Jovin, Sina; Lako, Majlinda (Journal article; Peer reviewed, 2024)
      The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity ...