Blar i Bergen Open Research Archive på forfatter "Grudic, Amra"
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Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres
Grudic, Amra; Jul-Larsen, Åsne; Haring, SJ; Wold, MS; Lønning, Per Eystein; Bjerkvig, Rolf; Bøe, Stig Ove (Peer reviewed; Journal article, 2007-10-24)The activation of a telomere maintenance mechanism is required for cancer development in humans. While most tumors achieve this by expressing the enzyme telomerase, a fraction (5–15%) employs a recombination-based mechanism ... -
Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein
Jul-Larsen, Åsne; Grudic, Amra; Bjerkvig, Rolf; Bøe, Stig O. (Peer reviewed; Journal article, 2010-11-21)Background The promyelocytic leukemia (PML) protein participates in a number of cellular processes, including transcription regulation, apoptosis, differentiation, virus defense and genome maintenance. This protein is ...