Blar i Bergen Open Research Archive på forfatter "Guldbrandsen, Astrid"
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Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis
Oveland, Eystein; Ahmad, Intakhar; Lereim, Ragnhild Reehorst; Kroksveen, Ann Cathrine; Barsnes, Harald; Guldbrandsen, Astrid; Myhr, Kjell-Morten; Bø, Lars; Berven, Frode Steingrimsen; Wergeland, Stig (Journal article; Peer reviewed, 2021)Two pathophysiological different experimental models for multiple sclerosis were analyzed in parallel using quantitative proteomics in attempts to discover protein alterations applicable as diagnostic-, prognostic-, or ... -
Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis
Guldbrandsen, Astrid; Lereim, Ragnhild Reehorst; Jacobsen, Mari; Garberg, Hilde Kristin; Kroksveen, Ann Cathrine; Barsnes, Harald; Berven, Frode (Journal article; Peer reviewed, 2020)Background: Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disease ... -
Essential Features and Use Cases of the Cerebrospinal Fluid Proteome Resource (CSF-PR)
Guldbrandsen, Astrid; Farag, Yehia Mohamed Mokhtar; Lereim, Ragnhild Reehorst; Berven, Frode; Barsnes, Harald (Peer reviewed; Journal article, 2019)Every year, a large number of published studies present biomarkers for various neurological disorders. Many of these studies are based on mass spectrometry proteomics data and describe comparison of the abundance of proteins ... -
In-depth cerebrospinal fluid quantitative proteome and deglycoproteome analysis: presenting a comprehensive picture of pathways and processes affected by multiple sclerosis
Kroksveen, Ann Cathrine; Guldbrandsen, Astrid; Vaudel, Marc; Lereim, Ragnhild Reehorst; Barsnes, Harald; Myhr, Kjell-Morten; Torkildsen, Øivind; Berven, Frode (Peer reviewed; Journal article, 2017)In the current study, we conducted a quantitative in-depth proteome and deglycoproteome analysis of cerebrospinal fluid (CSF) from relapsing-remitting multiple sclerosis (RRMS) and neurological controls using mass spectrometry ... -
In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR)
Guldbrandsen, Astrid; Vethe, Heidrun; Farag, Yehia Mohamed Mokhtar; Oveland, Eystein; Garberg, Hilde Kristin; Berle, Magnus Foldal; Myhr, Kjell-Morten; Opsahl, Jill Anette; Barsnes, Harald; Berven, Frode (Peer reviewed; Journal article, 2014-11)In this study, the human cerebrospinal fluid (CSF) proteome was mapped using three different strategies prior to Orbitrap LC-MS/MS analysis: SDS-PAGE and mixed mode reversed phase-anion exchange for mapping the global CSF ... -
Protein Post-Translational Modification Crosstalk in Acute Myeloid Leukemia Calls for Action
Hernandez-Valladares, Maria; Wangen, Rebecca; Berven, Frode; Guldbrandsen, Astrid (Peer reviewed; Journal article, 2019)Background: Post-translational modification (PTM) crosstalk is a young research field. However, there is now evidence of the extraordinary characterization of the different proteoforms and their interactions in a biological ...