• Candidate markers for stratification and classification in rheumatoid arthritis 

      Bader, Lucius; Gullaksen, Stein-Erik; Blaser, Nello; Brun, Morten; Bringeland, Gerd Haga; Sulen, Andre; Gjesdal, Clara Gram; Vedeler, Christian A.; Gavasso, Sonia (Peer reviewed; Journal article, 2019-07-05)
      Rheumatoid arthritis (RA) is a chronic autoimmune, inflammatory disease, characterized by synovitis in small- and medium-sized joints and, if not treated early and efficiently, joint damage, and destruction. RA is a ...
    • Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation 

      Reikvam, Håkon; Skavland, Jørn; Gullaksen, Stein-Erik; Hovland, Randi; Gedde-Dahl, Tobias; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2018-09-23)
      Chronic myeloid leukemia (CML) is a myeloproliferative disorder in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein BCR-ABL1. Allogeneic stem cell transplantation (allo-SCT) was ...
    • Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells 

      Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik; Sundøy, Silje Maria; Gjertsen, Bjørn Tore; Kotopoulis, Spiros; Mc Cormack, Emmet (Peer reviewed; Journal article, 2019-07-06)
      Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption ...
    • Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells 

      Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius; McClymont, David; Skavland, Jørn; Gavasso, Sonia; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-11)
      Hydrogen sulfide (H2S) is an endogenous gasotransmitter in human physiology and inflammatory disease, however, with limited knowledge of how signal transduction pathways are involved in immune cells. To examine the effects ...
    • Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib 

      Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Thobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Mohammed Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2017-08)
      Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted ...
    • Titrating complex mass cytometry panels 

      Gullaksen, Stein-Erik; Bader, Lucius; Hellesøy, Monica; Sulen, Andre; Fagerholt, Oda Helen Eck; Engen, Caroline Benedicte Nitter; Skavland, Jørn; Gjertsen, Bjørn Tore; Gavasso, Sonia (Peer reviewed; Journal article, 2019-07-13)
      We describe here a simple and efficient antibody titration approach for cell‐surface markers and intracellular cell signaling targets for mass cytometry. The iterative approach builds upon a well‐characterized backbone ...
    • Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines ( 

      Omsland, Maria; Andresen, Vibeke; Gullaksen, Stein-Erik; Ayuda-Duran, Maria del Pilar; Popa, Mihaela Lucia; Hovland, Randi; Brendehaug, Atle; Enserink, Jorrit; Mc Cormack, Emmet; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2020)
      Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where mechanisms of inter‐leukemic communication and cell‐to‐cell interactions are proposed to be important for optimal therapy response. Tunneling ...