• Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma 

      Gagnat, Ane Aamli; Gjerdevik, Miriam; Lie, Stein Atle; Gulsvik, Amund; Bakke, Per S.; Nielsen, Rune (Journal article; Peer reviewed, 2020)
      Rationale There is limited knowledge on the effect of acute exacerbations in chronic obstructive pulmonary disease (AECOPD) on lung cancer risk in COPD patients with and without a history of asthma. This study aims to ...
    • Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study 

      Ratanachina, Jate; Amaral, Andre F.S.; De Matteis, Sara; Lawin, Herve; Mortimer, Kevin; Obaseki, Daniel O.; Harrabi, Imed; Denguezli, Meriam; Wouters, Emiel F.M.; Janson, Christer; Nielsen, Rune; Gulsvik, Amund; Cherkaski, Hamid Hacene; Mejza, Filip; Mahesh, Padukudru Anand; Elsony, Asma; Ahmed, Rana; Tan, Wan C.; Loh, Li Cher; Rashid, Abdul; Studnicka, Michael; Nafees, Asaad A.; Seemungal, Terence; Aquart-Stewart, Althea; Al Ghobain, Mohammed; Zheng, Jinping; Juvekar, Sanjay; Salvi, Sundeep; Jogi, Rain; Mannino, David M.; Gislason, Thorarinn; Buist, A. Sonia; Cullinan, Paul; Burney, Peter G.J.; Hafizi, Hasan; Aliko, Anila; Bardhi, Donika; Tafa, Holta; Thanasi, Natasha; Mezini, Arian; Teferici, Alma; Todri, Dafina; Nikolla, Jolanda; Kazasi, Rezarta; Bengrait, Amira; Haddad, Tabarek; Zgaoula, Ibtissem; Ghit, Maamar; Roubhia, Abdelhamid; Boudra, Soumaya; Atoui, Feryal; Yakoubi, Randa; Benali, Rachid; Bencheikh, Abdelghani; Ait-Khaled, Nadia; Jenkins, Christine; Marks, Guy; Bird, Tessa; Espinel, Paola; Hardaker, Kate; Toelle, Brett; Dawes, Torkil; Lamprecht, Bernd; Schirhofer, Lea; Islam, Akramul; Ahmed, Syed Masud; Islam, Shayla; Islam, Qazi Shafayetul; Mesbah-Ul-Haque, NN; Chowdhury, Tridib Roy; Chatterjee, Sukantha Kumar; Mia, Dulal; Das, Shyamal Chandra; Rahman, Mizanur; Islam, Nazrul; Uddin, Shahaz; Islam, Nurul; Khatun, Luiza; Parvin, Monira; Khan, Abdul Awal; Islam, Maidul; Kpangon, Arsene; Kpossou, Karl; Agodokpessi, Gildas; Ayelo, Paul; Fayomi, Benjamin; Mbatchou, Bertrand; Ashu, Atongno Humphrey; Wang, Wen; Zhong, NanShan; Liu, Shengming; Lu, Jiachun; Ran, Pixin; Wang, Dali; Zhou, Yumin; Laja, Hendrik; Ulst, Katrin; Zobel, Vappu; Lill, Toomas-Julius; Adegnika, Ayola Akim; Welte, Tobias; Bodemann, Isabelle; Geldmacher, Henning; Schweda-Linow, Alexandra; Benedikdtsdottir, Bryndis; Jörundsdottir, Kristin; Gudmundsdottir, Lovisa; Gudmundsdottir, Sigrun; Gundmundsson, Gunnar; Koul, Parvaiz A.; Malik, Sajjad; Hakim, Nissar A.; Khan, Umar Hafiz; Chowgule, Rohini; Shetye, Vasant; Raphael, Jonelle; Almeda, Rosel; Tawde, Mahesh; Tadvi, Rafiq; Katkar, Sunil; Kadam, Milind; Dhanawade, Rupesh; Ghurup, Umesh; Hirve, Siddhi; Sambhudas, Somnath; Chaidhary, Bharat; Tambe, Meera; Pingale, Savita; Umap, Arati; Umap, Archana; Shelar, Nitin; Devchakke, Sampada; Chaudhary, Sharda; Bondre, Suvarna; Walke, Savita; Gawhane, Ashleshsa; Sapkal, Anil; Argade, Rupali; Gaikwad, Vijay; Brashier, Sundeep Bill; Londhe, Jyoti; Madas, Sapna; Aikman, Althea Akosua Francia; Sooronbaev, Talant M.; Estebesova, Bermet M.; Akmatalieva, Meerim; Usenbaeva, Saadat; Kydyrova, Jypara; Bostonova, Eliza; Sheraliev, Ulan; Marajapov, Nuridin; Toktogulova, Nurgul; Emilov, Berik; Azilova, Toktogul; Beishekeeva, Gulnara; Dononbaeva, Nasyikat; Tabyshova, Aijamal; Mwangoka, Ernest; Kambwili, Mayamiko; Chipeta, Martha; Banda, Gloria; Mkandawire, Suzgo; Banda, Justice; Sholehah, Siti; Benjelloun, Mohamed C.; Nejjari, Chakib; Elbiaze, Mohamed; El Rhazi, Karima; Franssen, F.F.E.; Wesseling, G.J.; Erhabor, Gregory; Awopeju, Olayemi; Adewole, Olufemi; Endresen, Tina; Svendsen, Lene Løvendahl; Irfan, Muhammad; Fatmi, Zafar; Zahidie, Aysha; Shaukat, Natasha; Iqbal, Meesha; Idolor, Luisito F.; de Guia, Teresita S.; Francisco, Norberto A.; Roa, Camilo C.; Ayuyao, Fernando G.; Tady, Cecil Z.; Tan, Daniel T.; Banal-Yang, Sylvia; Balanag, Vincent M.; Reyes, Maria Teresita N.; Dantes, Renato B.; Amarillo, Lourdes; Berratio, Lakan U.; Fernandez, Lenora C.; Garcia, Gerard S.; Naval, Sullian S.; Reyes, Thessa; Roa, Camilo C.; Sanchez, Ma. Flordeliza; Simpao, Leander P.; Nizankowska-Mogilnicka, Ewa; Frey, Jakub; Harat, Rafal; Nastalek, Pawel; Pajak, Andrzej; Skucha, Wojciech; Szczeklik, Andrzej; Twardowska, Magda; Bárbara, Cristina; Rodrigues, Fátima; Dias, Hermínia; Cardoso, João; Almeida, João; Matos, Maria João; Simão, Paula; Santos, Moutinho; Ferreira, Reis; Alorainy, H.; El-Hamad, E.; Al Hajjaj, Hajjaj; Hashi, A.; Dela, R.; Fanuncio, R.; Doloriel, E.; Marciano, I.; Safia, L.; Bateman, Eric; Jithoo, Anamika; Adams, Desiree; Barnes, Edward; Freeman, Jasper; Hayes, Anton; Hlengwa, Sipho; Johannisen, Christine; Koopman, Mariana; Louw, Innocentia; Ludick, Ina; Olckers, Alta; Ryck, Johanna; Storbeck, Janita; Gunasekera, Kirthi; Wickremasinghe, Rajitha; Elsadig, Hana A.; Osman, Nada Bakery; Noory, Bandar Salah; Mohamed, Monjda Awad; Osman, Hasab Alrasoul Akasha Ahmed; ed Elhassan, Namarig Moham; El Zain, Abdel Mu'is; Mohamaden, Marwa Mohamed; Khalifa, Suhaiba; Elhadi, Mahmoud; Hassan, Mohand; Abdelmonam, Dalia; Kamal, Rashid; Eltigani, Hind; Umar, Stephen's; Abdeen, Aya; Osman, Mihad; Mohamed, Malaz; Eltayeb, Roa; Abelazeez, Mohamed; Altaher, Hoyam; Mohamed, Lina; Abdarahman, Rabee; Mohamed, Rayan; Haram, NN; Ismaeel, Rimaz; Olafsdottir, Inga Sif; Nisser, Katarina; Spetz-Nyström, Ulrike; Hägg, Gunilla; Lund, Gun-Marie; Lutchmansingh, Fallon; Conyette, Liane; Tabka, Zouhair; Daldoul, Hager; Boukheroufa, Zaki; Chouikha, Firas; Khalifa, Wahbi Belhaj; Kocabaş, Ali; Hancioglu, Attila; Hanta, Ismail; Kuleci, Sedat; Turkyilmaz, Ahmet Sinan; Umut, Sema; Unalan, Turgay; Gnatiuc, Louisa; Azar, Hadia; Patel, Jaymini; Amor, Caron; Potts, James; Tumilty, Michael; McLean, Fiona; Dudhaiya, Risha; McBurnie, Mary Ann; Vollmer, William M.; Gillespie, Suzanne; Sullivan, Sean; Lee, Todd A.; Weiss, Kevin B.; Jensen, Robert L.; Crapo, Robert; Enright, Paul; Cain, John; Copeland, Rebecca; Hazen, Dana; Methvin, Jennifer (Journal article; Peer reviewed, 2023)
      Background Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive ...
    • Can spirometric norms be set using pre- or post- bronchodilator test results in older people? 

      Kato, Bernet; Gulsvik, Amund; Vollmer, William; Janson, Christer; Studnika, Michael; Buist, Sonia; Burney, Peter (Peer reviewed; Journal article, 2012-11-16)
      Background: Chronic Obstructive Pulmonary Disease (COPD) is defined by post-bronchodilator spirometry. Data on “normal values” come predominantly from pre-bronchodilator spirometry. The effects of this on diagnosis are ...
    • Change in pulmonary diffusion capacity in a general population sample over 9 years 

      Storebø, Michael Langballe; Eagan, Tomas Mikal; Eide, Geir Egil; Gulsvik, Amund; Thorsen, Einar; Bakke, Per S. (Peer reviewed; Journal article, 2016-09-02)
      Rationale: Data on the change in diffusion capacity of the lung for carbon monoxide (DLCO) over time are limited. We aimed to examine change in DLCO (ΔDLCO) over a 9-year period and its predictors. Methods: A Norwegian ...
    • Change in pulmonary diffusion capacity in a general population sample over 9 years 

      Storebø, Michael Langballe; Eagan, Tomas Mikal; Eide, Geir Egil; Gulsvik, Amund; Thorsen, Einar; Bakke, Per S. (Peer reviewed; Journal article, 2016-09-02)
      Rationale: Data on the change in diffusion capacity of the lung for carbon monoxide (DL_CO) over time are limited. We aimed to examine change in DL_CO (ΔDL_CO) over a 9-year period and its predictors. Methods: A Norwegian ...
    • Chronic airflow obstruction and ambient particulate air pollution 

      Amaral, André F.S.; Burney, Peter G.J.; Patel, Jaymini; Minelli, Cosetta; Mejza, F; Mannino, David M.; Seemungal, Terence A.R.; Mahesh, Padukudru Anand; Lo, Li Cher; Janson, Christer; Juvekar, Sanjay; Denguezli, Meriam; Harrabi, Imed; Wouters, Emiel F.M.; Cherkaski, Hamid; Mortimer, Kevin; Jogi, Rain; Bateman, Eric D.; Fuertes, Elaine; Al Ghobain, Mohammed; Tan, Wan; Obaseki, Daniel O.; El Sony, Asma; Studnicka, Michael; Aquart-Stewart, Althea; Koul, Parvaiz; Lawin, Herve; Nafees, Asaad Ahmed; Awopeju, Olayemi; Erhabor, Gregory E.; Gislason, Thorarinn; Welte, Tobias; Gulsvik, Amund; Nielsen, Rune; Gnatiuc, Louisa; Kocabas, Ali; Marks, Guy B.; Sooronbaev, Talant; Ngahane, Bertrand Hugo Mbatchou; Barbara, Cristina; Sonia Buist, Buist (Journal article; Peer reviewed, 2021)
      Smoking is the most well-established cause of chronic airflow obstruction (CAO) but particulate air pollution and poverty have also been implicated. We regressed sex-specific prevalence of CAO from 41 Burden of Obstructive ...
    • Diagnostic validity of fatal cerebral strokes and coronary deaths 

      Gulsvik, Anne K.; Gulsvik, Amund; Svendsen, Einar; Mæhle, Bjørn Ove; Thelle, Dag S.; Wyller, Torgeir B. (Peer reviewed; Journal article, 2011-03)
      Mortality statistics represent important endpoints in epidemiological studies. The diagnostic validity of cerebral stroke and ischemic heart disease recorded as the underlying cause of death in Norwegian mortality statistics ...
    • Early life environment and snoring in adulthood 

      Franklin, Karl A.; Janson, Christer; Gíslason, Thórarinn; Gulsvik, Amund; Gunnbjörnsdottir, Maria; Lærum, Birger Norderud; Lindberg, Eva; Norrman, Eva; Nyström, Lennarth; Omenaas, Ernst; Torén, Kjell; Svanes, Cecilie (Peer reviewed; Journal article, 2008-08-22)
      Background: To our knowledge, no studies of the possible association of early life environment with snoring in adulthood have been published. We aimed to investigate whether early life environment is associated with snoring ...
    • Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease 

      Lee, Jin H.; Cho, Michael H.; Hersh, Craig P.; McDonald, Merry-Lynn N.; Crapo, James D.; Bakke, Per; Gulsvik, Amund; Comellas, Alejandro P.; Wendt, Christine H.; Lomas, David A.; Kim, Victor; Silverman, Edwin K.; on behalf of the COPDGene and ECLIPSE Investigators (Peer reviewed; Journal article, 2014-09-21)
      Background: Chronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, and ...
    • Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease 

      Qiu, Weiliang; Cho, Michael H.; Riley, John H.; Anderson, Wayne H.; Singh, Dave; Bakke, Per; Gulsvik, Amund; Litonjua, Augusto A.; Lomas, David A.; Crapo, James D.; Beaty, Terri H.; Celli, Bartolome R.; Rennard, Stephen I.; Tal-Singer, Ruth; Fox, Steven M.; Silverman, Edwin K.; Hersh, Craig P. (Peer reviewed; Journal article, 2011-09-16)
      Previous expression quantitative trait loci (eQTL) studies have performed genetic association studies for gene expression, but most of these studies examined lymphoblastoid cell lines from non-diseased individuals. We ...
    • A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry 

      Lutz, Sharon M; Cho, Michael H; Young, Kendra; Hersh, Craig P; Castaldi, Peter J; McDonald, Merry-Lynn; Regan, Elizabeth; Mattheisen, Manuel; DeMeo, Dawn L; Parker, Margaret; Foreman, Marilyn; Make, Barry J; Jensen, Robert L; Casaburi, Richard; Lomas, David A; Bhatt, Surya P; Bakke, Per; Gulsvik, Amund; Crapo, James D; Beaty, Terri H; Laird, Nan M; Lange, Christoph; Hokanson, John E; Silverman, Edwin K (Peer reviewed; Journal article, 2015-12-03)
      Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ...
    • A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci 

      Pillai, Sreekumar G.; Ge, Dongliang; Zhu, Guohua; Kong, Xiangyang; Shianna, Kevin V.; Need, Anna C.; Feng, Sheng; Hersh, Craig P.; Bakke, Per S.; Gulsvik, Amund; Ruppert, Andreas; Carlsen, Karin Cecilie Lødrup; Roses, Allen; Anderson, Wayne; Rennard, Stephen I.; Lomas, David A.; Silverman, Edwin K.; Goldstein, David B. (Peer reviewed; Journal article, 2009-03-20)
      There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ...
    • A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts 

      Gereige, Jessica D.; Xu, Hanfei; Ortega, Victor E.; Cho, Michael H.; Liu, Ming; Sakornsakolpat, Phuwanat; Silverman, Edwin K.; Beaty, Terri H.; Miller, Bruce E.; Bakke, Per S.; Gulsvik, Amund; Hersh, Craig P.; Morrow, Jarrett D.; Ampleford, Elizabeth J.; Hawkins, Gregory A.; Bleecker, Eugene R.; Meyers, Deborah A.; Peters, Stephen P.; Celedón, Juan C.; Tantisira, Kelan; Li, Jiang; Dupuis, Josée; O’connor, George T. (Journal article; Peer reviewed, 2022)
      Introduction Bronchodilator response (BDR) is a measurement of acute bronchodilation in response to short-acting β2-agonists, with a heritability between 10 and 40%. Identifying genetic variants associated with BDR may ...
    • Incidence of utilization- and symptom-defined COPD exacerbations in hospital- and population-recruited patients 

      Erdal, Marta; Johannessen, Ane; Eagan, Tomas Mikal; Bakke, Per S.; Gulsvik, Amund; Grønseth, Rune (Peer reviewed; Journal article, 2016-09)
      Objectives: The objectives of this study were to estimate the impact of recruitment source and outcome definition on the incidence of acute exacerbations of COPD (AECOPD) and explore possible predictors of AECOPD. Patients ...
    • Incremental costs of COPD exacerbations in GOLD stage 2+ COPD in ever-smokers of a general population 

      Erdal, Marta; Johannessen, Ane; Bakke, Per S.; Gulsvik, Amund; Eagan, Tomas Mikal; Nielsen, Rune (Journal article; Peer reviewed, 2020-11)
      Objectives To estimate treatment- and productivity-related costs associated with COPD in two different samples, and to analyse the association between the costs and moderate and severe exacerbations. Methods We performed ...
    • Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer 

      Erdem, Johanna Samulin; Skaug, Vidar; Bakke, Per S.; Gulsvik, Amund; Haugen, Aage; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2016-01-19)
      Background: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC). SOX2 signaling is important in maintaining the stem cell-like phenotype ...
    • Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease 

      Aminuddin, Farzian; Hackett, Tillie-Louise; Stefanowicz, Dorota; Saferali, Aabida; Paré, Peter D.; Gulsvik, Amund; Bakke, Per; Cho, Michael H.; Litonjua, Augusto A.; Lomas, David A.; Anderson, Wayne H.; Beaty, Terri H.; Silverman, Edwin K.; Sandford, Andrew J. (Peer reviewed; Journal article, 2013-11-06)
      Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was ...
    • Period and cohort effects: consequences on spirometric lung function in Norway during the 20th century 

      Cestelli, Lucia; Johannessen, Ane; Stavem, Knut; Gulsvik, Amund; Nielsen, Rune (Journal article; Peer reviewed, 2022)
      Background and aim Several factors can influence measured lung function over time. The aim of this study was to investigate period and cohort effects on spirometric measures in a large general population sample in Norway ...
    • Prevalence and prognostic ability of the GOLD 2017 classification compared to the GOLD 2011 classification in a Norwegian COPD cohort 

      Le, Lan Ai Kieu; Johannessen, Ane; Hardie, Jon Andrew; Johansen, Odd Erik; Gulsvik, Amund; Vikse, Bjørn Egil; Bakke, Per S. (Peer reviewed; Journal article, 2019-07-23)
      Rationale: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 is based on an ABCD assessment tool of symptoms and exacerbation history and grade 1–4 of airflow limitation severity, facilitating ...
    • Respiratory symptoms and cardiovascular causes of deaths: A population-based study with 45 years of follow-up 

      Stavem, Knut; Schirmer, Henrik; Gulsvik, Amund (Journal article; Peer reviewed, 2022)
      This study determined the association between respiratory symptoms and death from cardiovascular (CV) diseases during 45 years in a pooled sample of four cohorts of random samples of the Norwegian population with 95,704 ...