• 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy 

      Joubert, Bonnie R.; Håberg, Siri Eldevik; Nilsen, Roy Miodini; Wang, Xuting; Vollset, Stein Emil; Murphy, Susan K; Huang, Zhiqing; Hoyo, Cathrine; Midttun, Øivind; Cupul-Uicab, Lea A; Ueland, Per Magne; Wu, Michael C; Nystad, Wenche; Bell, Douglas A; Peddada, Shyamal D; London, Stephanie J (Peer reviewed; Journal article, 2012-10)
      Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple ...
    • Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry 

      Bohlin, Jon; Page, Christian Magnus; Lee, Yunsung; Pettersson, John H.-O.; Jugessur, Astanand; Magnus, Per Minor; Håberg, Siri Eldevik (Journal article; Peer reviewed, 2022)
      Male sex and advanced age are associated with severe symptoms of COVID-19. Sex and age also exhibit substantial associations with genome-wide DNA methylation (DNAm) differences in humans. Using a random sample of Illumina ...
    • Antipsychotic use in pregnancy and risk of attention/ deficit-hyperactivity disorder and autism spectrum disorder: a Nordic cohort study 

      Halfdanarson, Oskar; Cohen, Jacqueline Mallory; Karlstad, Øystein; Cesta, Carolyn E.; Bjørk, Marte-Helene; Håberg, Siri Eldevik; Einarsdottir, Kristjana; Furu, Kari; Gissler, Mika; Hjellvik, Vidar; Kieler, Helle; Leinonen, Maarit; Nørgaard, Mette; Essen, Buket Öztürk; Ulrichsen, Sinna Pilgaard; Reutfors, Johan; Zoega, Helga (Journal article; Peer reviewed, 2021)
      Background Antipsychotics are increasingly used among women of childbearing age and during pregnancy. Objective To determine whether children exposed to antipsychotics in utero are at increased risk of attention-d ...
    • Association of Household Income With Life Expectancy and Cause-Specific Mortality in Norway, 2005-2015 

      Kinge, Jonas Minet; Modalsli, Jørgen Heibø; Øverland, Simon Nygaard; Gjessing, Håkon K.; Tollånes, Mette Christophersen; Knudsen, Ann Kristin; Skirbekk, Vegard Fykse; Strand, Bjørn Heine; Håberg, Siri Eldevik; Vollset, Stein Emil (Peer reviewed; Journal article, 2019-05-13)
      Importance: Examining causes of death and making comparisons across countries may increase understanding of the income-related differences in life expectancy. Objectives: To describe income-related differences in life ...
    • Associations between epigenetic age acceleration and infertility 

      Lee, Yunsung; Bohlin, Jon; Page, Christian Magnus; Nustad, Haakon E.; Harris, Jennifer Ruth; Magnus, Per Minor; Magnus, Per; Jugessur, Astanand; Magnus, Maria Christine; Håberg, Siri Eldevik; Hanevik, Hans Ivar (Journal article; Peer reviewed, 2022)
      Study question: Is the use of ART, a proxy for infertility, associated with epigenetic age acceleration? Summary answer: The epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed ...
    • Birthweight and childhood cancer: Preliminary findings from the international childhood cancer cohort consortium (I4C) 

      Paltiel, Ora; Tikellis, Gabriella; Linet, Martha; Golding, Jean; Lemeshow, Stanley; Phillips, Gary; Lamb, Karen; Stoltenberg, Camilla; Håberg, Siri Eldevik; Strøm, Marin; Granstrøm, Charlotta; Northstone, Kate; Klebanoff, Mark; Ponsonby, Anne-Louise; Milne, Elizabeth; Pedersen, Marie; Kogevinas, Manolis; Ha, Eunhee; Dwyer, Terence (Peer reviewed; Journal article, 2015-07)
      Background: Evidence relating childhood cancer to high birthweight is derived primarily from registry and case–control studies. We aimed to investigate this association, exploring the potential modifying roles of age at ...
    • Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium 

      Felix, Janine F.; Joubert, Bonnie R.; Baccarelli, Andrea A.; Sharp, Gemma C.; Almqvist, Catarina; Annesi-Maesano, Isabella; Arshad, Hasan; Baïz, Nour; Bakermans-Kranenburg, Marian J.; Bakulski, Kelly M.; Binder, Elisabeth B.; Bouchard, Luigi; Breton, Carrie V.; Brunekreef, Bert; Brunst, Kelly J.; Burchard, Esteban G.; Bustamante, Mariona; Chatzi, Leda; Munthe-Kaas, Monica Cheng; Corpeleijn, Eva; Czamara, Darina; Dabelea, Dana; Smith, George Davey; De Boever, Patrick; Duijts, Liesbeth; Dwyer, Terence; Eng, Celeste; Eskenazi, Brenda; Everson, Todd M.; Falahi, Fahimeh; Fallin, M. Daniele; Farchi, Sara; Fernández, Mariana F.; Gao, Lu; Gaunt, Tom R.; Ghantous, Akram; Gillman, Matthew W.; Gonseth, Semira; Grote, Veit; Gruzieva, Olena; Håberg, Siri Eldevik; Herceg, Zdenko; Hivert, Marie-France; Holland, Nina; Holloway, John W.; Hoyo, Cathrine; Hu, Donglei; Huang, Rae-Chi; Huen, Karen; Järvelin, Marjo-Riitta; Jima, Dereje D.; Just, Allan C.; Karagas, Margaret R.; Magnus, Per; Nystad, Wenche; Page, Christian; Lie, Rolv T.; Magnus, Maria Christine (Peer reviewed; Journal article, 2018-02)
    • Comorbidities treated in primary care in children with chronic fatigue syndrome 

      Bakken, Inger Johanne; Tveito, Kari; Aaberg, Kari Modalsli; Ghaderi, Sara; Gunnes, Nina; Trogstad, Lill; Magnus, Per; Stoltenberg, Camilla; Håberg, Siri Eldevik (Peer reviewed; Journal article, 2016-09-02)
      Background: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex condition. Causal factors are not established, although underlying psychological or immunological susceptibility has been proposed. We ...
    • DNA methylation in newborns conceived by assisted reproductive technology 

      Håberg, Siri Eldevik; Page, Christian Magnus; Lee, Yunsung; Nustad, Haakon Egdetveit; Magnus, Maria Christine; Haftorn, Kristine Løkås; Carlsen, Ellen Øen; Denault, William Robert Paul; Bohlin, Jon; Jugessur, Astanand; Magnus, Per Minor; Gjessing, Håkon Kristian; Lyle, Robert (Journal article; Peer reviewed, 2022)
      Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo ...
    • DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy 

      Reese, Sarah E; Zhao, Shanshan; Wu, Michael C; Joubert, Bonnie R; Parr, Christine Louise; Håberg, Siri Eldevik; Ueland, Per Magne; Nilsen, Roy Miodini; Midttun, Øivind; Vollset, Stein Emil; Peddada, Shyamal D; Nystad, Wenche; London, Stephanie J (Peer reviewed; Journal article, 2017-04)
      Background: Maternal smoking during pregnancy, especially when sustained, leads to numerous adverse health outcomes in offspring. Pregnant women disproportionately underreport smoking and smokers tend to have lower follow-up ...
    • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 

      Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit; Lyle, Robert; Gjessing, Håkon Kristian; Malmberg, Anni; Magnus, Maria Christine; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand; Bohlin, Jon (Journal article; Peer reviewed, 2021)
      Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate ...
    • Evaluating national guidelines for monitoring early growth using routinely collected data in Bergen, Norway 

      Balthasar, Melissa Rajini; Roelants, Mathieu; Brannsether-Ellingsen, Bente; Stangenes, Kristine Marie; Magnus, Maria Christine; Håberg, Siri Eldevik; Øverland, Simon Nygaard; Juliusson, Pétur Benedikt (Journal article; Peer reviewed, 2023)
      Aims: The overarching aim of this study was to evaluate the Norwegian guidelines for growth monitoring using routinely collected data from healthy children up to five years of age. We analysed criteria for both status ...
    • An examination of mediation by DNA methylation on birthweight differences induced by assisted reproductive technologies 

      Carlsen, Ellen Øen; Lee, Yunsung; Magnus, Per Minor; Jugessur, Astanand; Page, Christian Magnus; Nustad, Haakon Egdetveit; Håberg, Siri Eldevik; Lie, Rolv Terje; Magnus, Maria Christine (Journal article; Peer reviewed, 2022)
      Background Children born after assisted reproductive technologies (ART) differ in birthweight from those naturally conceived. It has been hypothesized that this might be explained by epigenetic mechanisms. We examined ...
    • Growth in children conceived by ART 

      Magnus, Maria Christine; Wilcox, Allen J.; Fadum, Elin Anita; Gjessing, Håkon; Opdahl, Signe; Juliusson, Petur Benedikt; Romundstad, Liv Bente; Håberg, Siri Eldevik (Journal article; Peer reviewed, 2021)
      STUDY QUESTION Is the growth pattern of children conceived by ART different compared to naturally conceived children. SUMMARY ANSWER Both ART and underlying parental subfertility may contribute to differences in early ...
    • Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway 

      Ghaderi, Sara; Berg-Hansen, Pål; Bakken, Inger Johanne Landsjøåsen; Magnus, Per; Trogstad, Lill; Håberg, Siri Eldevik (Peer reviewed; Journal article, 2020)
      Patients with multiple sclerosis (MS) are at increased risk of infections and related worsening of neurological function. Influenza infection has been associated with increased risk of various neurological complications. ...
    • Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder 

      Gustavson, Kristin; Ask, Helga; Ystrøm, Eivind; Stoltenberg, Camilla; Lipkin, W. Ian; Suren, Pål; Håberg, Siri Eldevik; Magnus, Per; Knudsen, Gun Peggy S.; Eilertsen, Espen Moen; Bresnahan, Michaeline; Aase, Heidi; Mjaaland, Siri; Susser, Ezra S.; Hornig, Mady; Reichborn-Kjennerud, Ted (Peer reviewed; Journal article, 2019-07-02)
      Maternal fever during pregnancy is associated with several adverse child outcomes. We investigated associations between maternal fever and ADHD among offspring, as well as the sub-dimensions of ADHD - inattention and ...
    • Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns 

      Joubert, Bonnie R; Den Dekker, Herman T; Felix, Janine F; Bohlin, Jon; Ligthart, Symen; Beckett, Emma; Tiemeier, Henning; van Meurs, Joyce B; Uitterlinden, Andre G; Hofman, Albert; Håberg, Siri Eldevik; Reese, Sarah E; Peters, Marjolein J; Kulle Andreassen, Bettina; Steegers, Eric A P; Nilsen, Roy Miodini; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Franco, Oscar H; Dehghan, Abbas; De Jongste, Johan C; Wu, Michael C; Wang, Tianyuan; Peddada, Shyamal D; Jaddoe, Vincent W V; Nystad, Wenche; Duijts, Liesbeth; London, Stephanie J (Peer reviewed; Journal article, 2016-02-10)
      Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development ...
    • Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero 

      Rotroff, Daniel M; Joubert, Bonnie R; Marvel, Skylar W; Håberg, Siri Eldevik; Wu, Michael C; Nilsen, Roy Miodini; Ueland, Per Magne; Nystad, Wenche; London, Stephanie J; Motsinger-Reif, Alison (Peer reviewed; Journal article, 2016-11-25)
      Background: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend ...
    • Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight 

      Küpers, Leanne K.; Monnereau, Claire; Sharp, Gemma C.; Yousefi, Paul; Salas, Lucas A.; Ghantous, Akram; Page, Christian Magnus; Reese, Sarah E.; Wilcox, Allen J.; Czamara, Darina; Starling, Anne P.; Novoloaca, Alexei; Lent, Samantha; Roy, Ritu; Hoyo, Cathrine; Breton, Carrie V.; Allard, Catherine; Just, Allan C.; Bakulski, Kelly M.; Holloway, John W.; Everson, Todd M.; Xu, Cheng-Jian; Huang, Rae-Chi; van der Plaat, Diana A.; Wielscher, Matthias; Merid, Simon Kebede; Ullemar, Vilhelmina; Rezwan, Faisal I.; Lahti, Jari; van Dongen, Jenny; Langie, Sabine A.S.; Richardson, Tom G.; Magnus, Maria Christine; Nohr, Ellen A.; Xu, Zongli; Duijts, Liesbeth; Zhao, Shanshan; Zhang, Weiming; Plusquin, Michelle; DeMeo, Dawn L.; Solomon, Olivia; Heimovaara, Joosje H.; Jima, Dereje D.; Gao, Lu; Bustamante, Mariona; Perron, Patrice; Wright, Robert O.; Hertz-Picciotto, Irva; Zhang, Hongmei; Karagas, Margaret R.; Gehring, Ulrike; Marsit, Carmen J.; Beilin, Lawrence J.; Vonk, Judith M.; Jarvelin, Marjo-Riitta; Bergström, Anna; Örtqvist, Anne K.; Ewart, Susan; Villa, Pia M.; Moore, Sophie E.; Willemsen, Gonneke; Standaert, Arnout R.L.; Håberg, Siri Eldevik; Sørensen, Thorkild I.A.; Taylor, Jack A.; Räikkönen, Katri; Yang, Ivana V.; Kechris, Katerina; Nawrot, Tim S.; Silver, Matt J.; Gong, Yun Yun; Richiardi, Lorenzo; Kogevinas, Manolis; Litonjua, Augusto A.; Eskenazi, Brenda; Huen, Karen; Mbarek, Hamdi; Maguire, Rachel L.; Dwyer, Terence; Vrijheid, Martine; Bouchard, Luigi; Baccarelli, Andrea A.; Croen, Lisa A.; Karmaus, Wilfried; Anderson, Denise; de Vries, Maaike; Sebert, Sylvain; Kere, Juha; Karlsson, Robert; Arshad, Syed Hasan; Hämäläinen, Esa; Routledge, Michael N.; Boomsma, Dorret I.; Feinberg, Andrew P.; Newschaffer, Craig J.; Govarts, Eva; Moisse, Matthieu; Fallin, M. Daniele; Melén, Erik; Prentice, Andrew M.; Kajantie, Eero; Almqvist, Catarina; Oken, Emily; Dabelea, Dana; Boezen, H. Marike; Melton, Philip E.; Wright, Rosalind J.; Koppelman, Gerard H.; Trevisi, Letizia; Hivert, Marie-France; Sunyer, Jordi; Munthe-Kaas, Monica Cheng; Murphy, Susan K.; Corpeleijn, Eva; Wiemels, Joseph L.; Holland, Nina; Herceg, Zdenko; Binder, Elisabeth B.; Davey Smith, George; Jaddoe, Vincent V.W.; Lie, Rolv T.; Nystad, Wenche; London, Stephanie J.; Lawlor, Debbie A.; Relton, Caroline L.; Snieder, Harold; Felix, Janine F. (Peer reviewed; Journal article, 2019-04-23)
      Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in ...
    • Narcolepsy and hypersomnia in Norwegian children and young adults following the influenza A(H1N1) 2009 pandemic 

      Trogstad, Lill; Bakken, Inger Johanne; Gunnes, Nina; Ghaderi, Sara; Stoltenberg, Camilla; Magnus, Per; Håberg, Siri Eldevik (Peer reviewed; Journal article, 2017-04)
      Background: Associations between influenza infection and sleep disorders are poorly studied. We investigated if pandemic influenza infection or vaccination with Pandemrix in 2009/2010 was associated with narcolepsy or ...