Browsing Bergen Open Research Archive by Author "Hagen, Karen Marie"

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CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors

Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen; Hagen, Karen Marie; Lavecchia, Antonio; Bruserud, Øystein (Peer reviewed; Journal article, 2017-03-11)

Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. ...
The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells

Reikvam, Håkon; Brenner, Annette; Hagen, Karen Marie; Liseth, Knut; Skrede, Silje; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2015-11)

Interactions between acute myeloid leukemia (AML) blasts and neighboring stromal cells are important for disease development and chemosensitivity. However, the molecular mechanisms involved in the cytokine-mediated crosstalk ...