Browsing Bergen Open Research Archive by Author "Halvorsen, Ole Johan"
Now showing items 1-9 of 9
-
The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Mannelqvist, Monica; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2021)The prognostic importance of transcription factors promoting epithelial–mesenchymal transition (EMT) and angiogenesis has not been well explored in prostate cancer patients with long follow-up, nor the interplay between ... -
FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Beisland, Christian; Akslen, Lars A.; Halvorsen, Ole Johan (Peer reviewed; Journal article, 2019)Epithelial–mesenchymal transition (EMT) is important for tumour cell invasion and metastasis and is a feature of aggressive carcinomas. EMT is characterised by reduced E‐cadherin and increased N‐cadherin expression ... -
Higher than expected and significantly increasing incidence of upper tract urothelial carcinoma. A population based study
Almås, Bjarte; Halvorsen, Ole Johan; Johannessen, Tom Børge; Beisland, Christian (Journal article; Peer reviewed, 2021)Purpose: To register all cases of urothelial cancer and renal cell carcinoma (RCC) in Norway during 1999–2018 to obtain the contemporary incidence of UTUC and UTUC incidence relative to other urothelial cancers and RCC. ... -
MicroRNAs in Differentiation of Embryoid Bodies and the Teratoma Subtype of Testicular Cancer
Myklebust, Mette Pernille; Søviknes, Anne Mette; Halvorsen, Ole Johan; Thor, Anna; Dahl, Olav; Ræder, Helge (Journal article; Peer reviewed, 2022)Background: Testicular germ cell tumours (TGCTs) are the most frequent tumour type among young, adult men. TGCTs can be efficiently treated, but metastases of the teratoma subtype, for which there are no circulating ... -
Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer
Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ... -
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne; Almås, Bjarte; Børretzen, Astrid; Helle, Svein Inge; Førde, Kristina; Kristoffersen, Einar Klæboe; Kaada, Silje Katrine Helland; Melve, Guro Kristin; Haslerud, Torjan Magne; Biermann, Martin; Bigalke, Iris; Kvalheim, Gunnar; Azeem, Waqas; Olsen, Jan Roger; Gabriel, Benjamin; Knappskog, Stian; Halvorsen, Ole Johan; Akslen, Lars Andreas; Bahn, Duke; Pantel, Klaus; Riethdorf, Sabine; Ragde, Haakon; Gjertsen, Bjørn Tore; Øyan, Anne Margrete; Kalland, Karl Henning; Beisland, Christian (Journal article; Peer reviewed, 2023)Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ... -
Preoperative predictors of pathological tumour stage and prognosis may be used when selecting candidates for intensified treatment in upper tract urothelial carcinoma
Almås, Bjarte; Øverby, Stein; Halvorsen, Ole Johan; Reisæter, Lars Anders Rokne; Carlsen, Birgitte; Beisland, Christian (Journal article; Peer reviewed, 2021)Purpose: Intensified treatment such as extended lymph node dissection (LND) and/or perioperative chemotherapy in addition to radical nephroureterectomy (RNU) has been suggested for high-risk cases of upper tract urothelial ... -
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression
Sui, Lufei; Wang, Suming; Ganguly, Debolina; El Rayes, Tyler P.; Askeland, Cecilie; Børretzen, Astrid; Sim, Danielle; Halvorsen, Ole Johan; Knutsvik, Gøril; Arnes, Jarle; Aziz, Sura Mohammed; Haukaas, Svein Andreas; Foulkes, William D.; Bielenberg, Diane R.; Ziemys, Arturas; Mittal, Vivek; Brekken, Rolf A.; Akslen, Lars Andreas; Watnick, Randolph (Journal article; Peer reviewed, 2022)The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ... -
Ten-Year Results From a Phase II Study on Image Guided, Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost in High-Risk Prostate Cancer
Ekanger, Christian; Helle, Svein Inge; Heinrich, Daniel; Johannessen, Dag Clement; Karlsdottir, Åsa; Nygård, Yngve; Halvorsen, Ole Johan; Reisæter, Lars Anders Rokne; Kvåle, Rune; Hysing, Liv Bolstad; Dahl, Olav (Journal article; Peer reviewed, 2020)Purpose There is no consensus on how to treat high-risk prostate cancer, and long-term results from hypofractionated radiation therapy are lacking. We report 10-year results after image guided, intensity modulated radiation ...