Blar i Bergen Open Research Archive på forfatter "Hammenfors, Daniel"
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Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation
Sarkar, Irene; Davies, Richard Allan; Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Petrovic, Aleksandra; Joshi, Anagha; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Appel, Silke (Journal article; Peer reviewed, 2022)Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity ... -
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam; Bianchi, Matteo; Lundström, Emeli; Eloranta, Maija-Leena; Sandling, Johanna K.; Sjöwall, Christopher; Jönsen, Andreas; Gunnarsson, Iva; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Leonard, Dag; Baecklund, Eva; Jonsson, Roland; Hammenfors, Daniel; Forsblad-d'Elia, Helena; Eriksson, Per; Mandl, Thomas; Magnusson Bucher, Sara; Norheim, Katrine Brække; Johnsen, Svein Joar Auglæn; Omdal, Roald; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Notarnicola, Antonella; Andersson, Anna Helena; Molberg, Øyvind; Diederichsen, Louise Pyndt; Almlöf, Jonas; Syvänen, Ann-Christine; Kozyrev, Sergey V.; Lindblad-Toh, Kerstin; Rönnblom, Lars; Brokstad, Karl Albert; Skarstein, Kathrine; Jonsson, Malin Viktoria; Appel, Silke; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Palm, Øyvind; Nilsson, Birgitta Blakstad; Blom, Anna M.; Lundberg, Ingrid E.; Nordmark, Gunnel; Diaz-Gallo, Lina Marcela; Svenungsson, Elisabet; Rönnblom, Lars (Journal article; Peer reviewed, 2022)Objective Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation ... -
Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang; Reksten, Tove Ragna; Adler, Adam; Alevizos, Ilias; Anaya, Juan-Manuel; Aqrawi, Lara A.; Baecklund, Eva; Brun, Johan Gorgas; Bucher, Sara Magnusson; Eloranta, Maija-Leena; Engelke, Fiona; Forsblad-d’Elia, Helena; Glenn, Stuart B.; Hammenfors, Daniel; Imgenberg-Kreuz, Juliana; Jensen, Janicke Liaaen; Johnsen, Svein Joar Auglæn; Jonsson, Malin Viktoria; Kvarnström, Marika; Kelly, Jennifer A.; Li, He; Mandl, Thomas; Martín, Javier; Nocturne, Gaétane; Norheim, Katrine Brække; Palm, Øyvind; Skarstein, Kathrine; Stolarczyk, Anna M.; Taylor, Kimberly E.; Teruel, Maria; Theander, Elke; Venuturupalli, Swamy; Wallace, Daniel J.; Grundahl, Kiely M.; Hefner, Kimberly S.; Radfar, Lida; Lewis, David M.; Stone, Donald U.; Kaufman, C. Erick; Brennan, Michael T.; Guthridge, Joel M.; James, Judith A.; Scofield, R. Hal; Gaffney, Patrick M.; Criswell, Lindsey A.; Jonsson, Roland; Eriksson, Per; Bowman, Simon J.; Omdal, Roald; Rönnblom, Lars; Warner, Blake; Rischmueller, Maureen; Witte, Torsten; Farris, A. Darise; Mariette, Xavier; Alarcon-Riquelme, Marta E.; Shiboski, Caroline H.; Herlenius, Marie Elisabeth Wahren; Ng, Wan-Fai; Sivils, Kathy L.; Adrianto, Indra; Nordmark, Gunnel; Lessard, Christopher J. (Journal article; Peer reviewed, 2022)Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of ... -
Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome
Keindl, Magdalena; Davies, Richard Allan; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Lyssenko, Valeriya; Appel, Silke (Journal article; Peer reviewed, 2022)Background Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. ... -
Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary Sjögren's syndrome
Davies, Richard Allan; Sarkar, Irene; Hammenfors, Daniel; Bergum, Brith; Vogelsang, Petra; Solberg, Silje Michelsen; Gavasso, Sonia; Brun, Johan G; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2019-02-21)Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate and type I IFN immune response. Excessive activation potential of signaling pathways ... -
Strong association of combined genetic deficiencies in the classical complement pathway with risk of systemic lupus erythematosus and primary Sjögren's syndrome
Lundtoft, Christian; Sjöwall, Christopher; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Jönsen, Andreas; Pucholt, Pascal; Wu, Yee Ling; Lundström, Emeli; Eloranta, Maija-Leena; Gunnarsson, Iva; Baecklund, Eva; Jonsson, Roland; Hammenfors, Daniel; Forsblad-d'Elia, Helena; Eriksson, Per; Mandl, Thomas; Bucher, Sara; Norheim, Katrine Brække; Johnsen, Svein Joar Auglæn; Omdal, Roald; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Truedsson, Lennart; Nilsson, Bo; Kozyrev, Sergey V.; Bianchi, Matteo; Lindblad-Toh, Kerstin; Yu, Chack-Yung; Nordmark, Gunnel; Sandling, Johanna K.; Svenungsson, Elisabet; Leonard, Dag; Rönnblom, Lars (Journal article; Peer reviewed, 2022)Objective Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or primary ... -
Understanding fatigue in Sjögren’s Syndrome: Outcome measures, biomarkers and possible interventions
Mæland, Elisabeth; Miyamoto, Samira T.; Hammenfors, Daniel; Valim, Valeria; Jonsson, Malin Viktoria (Journal article; Peer reviewed, 2021)Sjögren’s syndrome (SS) is an autoimmune disease affecting the salivary and lacrimal glands. Symptoms range from dryness to severe extra-glandular disease involving manifestations in the skin, lungs, nervous system, and ... -
Weight of salivary gland ultrasonography compared to other items of the 2016 ACR/EULAR classification criteria for Primary Sjögren's syndrome
Jousse-Joulin, Sandrine; Gatineau, Florence; Baldini, Chiara; Baer, Alan; Barone, Francesca; Bootsma, Hendrika; Bowman, Simon Jonathan; Brito-Zerón, Pilar; Cornec, Divi; Dörner, Thomas; de Vita, Salvatore; Fisher, Benjamin A.; Hammenfors, Daniel; Jonsson, Malin V; Mariette, Xavier; Milić, Vera D.; Nakamura, Hideki; Ng, Wan-Fai; Nowak, Emmanuel; Ramos-Casals, Manuel; Rasmussen, Astrid; Séror, Raphaèle; Shiboski, Caroline H.; Nakamura, Takashi; Vissink, Arjan; Saraux, Alain; Devauchelle-Pensec, Valérie (Peer reviewed; Journal article, 2020)Objective: Major salivary gland ultrasonography (SGUS) is widely used for the diagnosis of primary Sjögren’s syndrome (pSS). Our objective was to assess the contribution of SGUS compared to other items of the 2016 ACR/EULAR ...