Browsing Bergen Open Research Archive by Author "Handeland, Andreas Havsgård"
Now showing items 1-4 of 4
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A case-control study of linear energy transfer and relative biological effectiveness related to symptomatic brainstem toxicity following pediatric proton therapy
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland; Lassen-Ramshad, Yasmin; Muren, Ludvig Paul; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2022)Background and purpose A fixed relative biological effectiveness (RBE) of 1.1 (RBE1.1) is used clinically in proton therapy even though the RBE varies with properties such as dose level and linear energy transfer (LET). ... -
Influence of beam pruning techniques on LET and RBE in proton arc therapy
Henjum, Helge; Tjelta, Johannes; Fjæra, Lars Fredrik; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Lyngholm, Erlend; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)Introduction: Proton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk. We aimed to investigate if pruning ... -
Linear energy transfer-inclusive models of brainstem necrosis following proton therapy of paediatric ependymoma
Handeland, Andreas Havsgård; Indelicato, Daniel J.; Fjæra, Lars Fredrik; Ytre-Hauge, Kristian Smeland; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2023)Background and Purpose Radiation-induced brainstem necrosis after proton therapy is a severe toxicity with potential association to uncertainties in the proton relative biological effectiveness (RBE). A constant RBE of ... -
Modelling of Brainstem Toxicity Including Variable Relative Biological Effectiveness in Paediatric Proton Therapy
Handeland, Andreas Havsgård (Master thesis, 2021-06-01)Brainstem necrosis is a rare but severe side-effect following paediatric proton therapy. Substructures of the brainstem may be associated with regional differences in radiosensitivity, but these are not accounted for ...