Browsing Bergen Open Research Archive by Author "Hanevik, Kurt"
Now showing items 1-20 of 30
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Assessment of malaria real-time PCR methods and application with focus on lowlevel parasitaemia
Haanshuus, Christel Gill; Mørch, Kristine; Blomberg, Bjørn; Strøm, Gro Elizabeth Ann; Langeland, Nina; Hanevik, Kurt; Mohn, Stein Christian (Peer reviewed; Journal article, 2019-07-05)In epidemiological surveys and surveillance the application of molecular tools is essential in detecting submicroscopic malaria. A genus-specific conventional cytochrome b (cytb) PCR has shown high sensitivity in field ... -
Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course
Mørch, Kristine; Hanevik, Kurt; Rivenes, Ann Christin; Bødtker, Jørn; Næss, Halvor; Stubhaug, Bjarte; Wensaas, Knut-Arne; Rørtveit, Guri; Eide, Geir Egil; Hausken, Trygve; Langeland, Nina (Peer reviewed; Journal article, 2013-02-12)Background: A high prevalence of chronic fatigue has previously been reported following giardiasis after a large waterborne outbreak in Bergen, Norway in 2004. The aim of this study was to describe and evaluate differential ... -
Development of functional gastrointestinal disorders after Giardia lamblia infection
Hanevik, Kurt; Dizdar, Vernesa; Langeland, Nina; Hausken, Trygve (Peer reviewed; Journal article, 2009-04-21)Background: Functional gastrointestinal disorders (FGID) may occur following acute gastroenteritis. This long-term complication has previously not been described after infection with the non-invasive protozoan Giardia ... -
Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Kleppa, Elisabeth; Lillebø, Kristine; Sævik, Marianne; Søyland, Hanne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen M.; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-06-22)Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled ... -
Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination
Moyo, Sabrina John; Blomberg, Bjørn; Hanevik, Kurt; Kommedal, Øyvind; Vainio, Kirsti; Maselle, Samwel Y.; Langeland, Nina (Peer reviewed; Journal article, 2014-05-20)Background: Tanzania currently rolls out vaccination against rotavirus-diarrhea, a major cause of child illness and death. As the vaccine covers a limited number of rotavirus variants, this study describes the molecular ... -
Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical giardia lamblia assemblage A and B isolates
Saghaug, Christina Skår; Klotz, Christian; Kallio, Juha Pekka; Brattbakk, Hans-Richard; Stokowy, Tomasz; Aebischer, Toni; Kursula, Inari; Langeland, Nina; Hanevik, Kurt (Peer reviewed; Journal article, 2019-05-10)Purpose: Treatment-refractory Giardia cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established yet, but several enzymes and their pathways ... -
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
Hanevik, Kurt; Kristoffersen, Einar; Mørch, Kristine; Rye, Kristin Paulsen; Sørnes, Steinar; Svärd, Staffan; Bruserud, Øystein; Langeland, Nina (Peer reviewed; Journal article, 2017-01-28)Background: The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. ... -
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome
Hanevik, Kurt; Kristoffersen, Einar K.; Sørnes, Steinar; Mørch, Kristine; Næss, Halvor; Rivenes, Ann Christin; Bødtker, Jørn; Hausken, Trygve; Langeland, Nina (Peer reviewed; Journal article, 2012-10-14)Background: A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting ... -
Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
Rajilic-Stojanovic, Mirjana; Jonkers, Daisy M; Salonen, Anne; Hanevik, Kurt; Raes, Jeroen; Jalanka, Jonna; de Vos, Willem M; Manichanh, Chaysavanh; Golic, Natasa; Enck, Paul; Elena, Philippou; Iraqi, Fuad A; Clarke, Gerard; Spiller, Robin C; Penders, John (Peer reviewed; Journal article, 2015-01-27)Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, ... -
Irritable Bowel Syndrome and Chronic Fatigue 6 Years After Giardia Infection: A Controlled Prospective Cohort Study
Hanevik, Kurt; Wensaas, Knut-Arne; Rørtveit, Guri; Eide, Geir Egil; Mørch, Kristine; Langeland, Nina (Peer reviewed; Journal article, 2014-08-12)Background. Functional gastrointestinal disorders and fatigue may follow acute infections. This study aimed to estimate the persistence, prevalence, and risk of irritable bowel syndrome and chronic fatigue 6 years after ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Rykkje Heien, Astrid; Gjerde Tellevik, Marit; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
Haanshuus, Christel Gill; Mohn, Stein Christian; Mørch, Kristine; Langeland, Nina; Blomberg, Bjørn; Hanevik, Kurt (Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
Haanshuus, Christel Gill; Mohn, Stein Christian; Mørch, Kristine; Langeland, Nina; Blomberg, Bjørn; Hanevik, Kurt (Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
Perceived food intolerance and irritable bowel syndrome in a population 3 years after a giardiasis-outbreak: a historical cohort study
Litleskare, Sverre; Wensaas, Knut-Arne; Eide, Geir Egil; Hanevik, Kurt; Kahrs, Gudrun E; Langeland, Nina; Rørtveit, Guri (Peer reviewed; Journal article, 2015-11-19)Background: Studies have shown an increased prevalence of irritable bowel syndrome (IBS) after acute gastroenteritis. Food as a precipitating and perpetuating factor in IBS has gained recent interest, but food intolerance ... -
Performance and operational feasibility of two diagnostic tests for cryptosporidiosis in children (CRYPTO-POC): a clinical, prospective, diagnostic accuracy study
Johansen, Øystein Haarklau; Abdissa, Alemseged; Zangenberg, Mike; Mekonnen, Zeleke; Eshetu, Beza; Bjørang, Ola; Alemu, Yonas; Sharew, Bizuwarek; Langeland, Nina; Robertson, Lucy; Hanevik, Kurt (Journal article; Peer reviewed, 2020)Background: Cryptosporidiosis is a common cause of diarrhoea in young children (aged younger than 24 months) in low-resource settings but is currently challenging to diagnose. Light-emitting diode fluorescence microscopy ... -
Post epidemic giardiasis and gastrointestinal symptoms among preschool children in Bergen, Norway. A cross-sectional study
Mellingen, Kristin M.; Midtun, Anita; Hanevik, Kurt; Eide, Geir Egil; Søbstad, Øystein; Langeland, Nina (Peer reviewed; Journal article, 2010-03-26)Background A surprisingly low number of children became ill with giardiasis during the large waterborne outbreak of Giardia lamblia in Bergen, Norway during autumn 2004. The aim of the present study was to evaluate the ... -
Post-giardiasis functional gastrointestinal disorders and chronic fatigue syndrome – clinical symptoms, inflammation and immune responses
Hanevik, Kurt (Doctoral thesis, 2012-01-20) -
Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis
Wensaas, Knut-Arne; Hanevik, Kurt; Hausken, Trygve; Eide, Geir Egil; Langeland, Nina; Mørch, Kristine; Rørtveit, Guri (Peer reviewed; Journal article, 2016)Background: Irritable bowel syndrome (IBS) is a common complication following gastroenteritis, and a high prevalence of postgiardiasis IBS has previously been reported. This study aims to investigate the prevalence, adjusted ... -
Prevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control study
Moyo, Sabrina John; Hanevik, Kurt; Blomberg, Bjørn; Kommedal, Øyvind; Nordbø, Svein Arne; Maselle, Samuel Y; Langeland, Nina (Peer reviewed; Journal article, 2014-12-12)Background: Human adenovirus (HAdV) causes acute diarrhoea sporadically, as well as in outbreaks. Understanding the prevalence and types of HAdV in diarrhoea is important for control and preventive measures, especially in ... -
Prevalence of Cryptosporidium parvum/hominis, Entamoeba histolytica and Giardia lamblia among Young Children with and without Diarrhea in Dar es Salaam, Tanzania
Tellevik, Marit Gjerde; Moyo, Sabrina John; Blomberg, Bjørn; Hjøllo, Torunn; Maselle, Samuel Y; Langeland, Nina; Hanevik, Kurt (Peer reviewed; Journal article, 2015-10-09)Background: Although enteroparasites are common causes of diarrheal illness, few studies have been performed among children in Tanzania. This study aimed to investigate the prevalence of Cryptosporidium parvum/hominis, ...