Blar i Bergen Open Research Archive på forfatter "Hanevik, Kurt"
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Assessment of malaria real-time PCR methods and application with focus on lowlevel parasitaemia
Haanshuus, Christel Gill; Mørch, Kristine; Blomberg, Bjørn; Strøm, Gro Elizabeth Ann; Langeland, Nina; Hanevik, Kurt; Mohn, Stein Christian (Peer reviewed; Journal article, 2019-07-05)In epidemiological surveys and surveillance the application of molecular tools is essential in detecting submicroscopic malaria. A genus-specific conventional cytochrome b (cytb) PCR has shown high sensitivity in field ... -
Bacteraemia, Malaria, and Case Fatality Among Children Hospitalized With Fever in Dar es Salaam, Tanzania
Moyo, Sabrina John; Manyahi, Joel; Blomberg, Bjørn; Tellevik, Marit Gjerde; Masoud, Nahya Salim; Aboud, Said; Manji, Karim; Roberts, Adam P.; Hanevik, Kurt; Mørch, Kristine; Langeland, Nina (Journal article; Peer reviewed, 2020)Background: Febrile illness is the commonest cause of hospitalization in children <5 years in sub-Saharan Africa, and bacterial bloodstream infections and malaria are major causes of death. Methods: From March 2017 to ... -
Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course
Mørch, Kristine; Hanevik, Kurt; Rivenes, Ann Christin; Bødtker, Jørn; Næss, Halvor; Stubhaug, Bjarte; Wensaas, Knut-Arne; Rørtveit, Guri; Eide, Geir Egil; Hausken, Trygve; Langeland, Nina (Peer reviewed; Journal article, 2013-02-12)Background: A high prevalence of chronic fatigue has previously been reported following giardiasis after a large waterborne outbreak in Bergen, Norway in 2004. The aim of this study was to describe and evaluate differential ... -
Development of functional gastrointestinal disorders after Giardia lamblia infection
Hanevik, Kurt; Dizdar, Vernesa; Langeland, Nina; Hausken, Trygve (Peer reviewed; Journal article, 2009-04-21)Background: Functional gastrointestinal disorders (FGID) may occur following acute gastroenteritis. This long-term complication has previously not been described after infection with the non-invasive protozoan Giardia ... -
Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Kleppa, Elisabeth; Lillebø, Kristine; Sævik, Marianne; Søyland, Hanne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen M.; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-06-22)Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled ... -
Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination
Moyo, Sabrina John; Blomberg, Bjørn; Hanevik, Kurt; Kommedal, Øyvind; Vainio, Kirsti; Maselle, Samwel Y.; Langeland, Nina (Peer reviewed; Journal article, 2014-05-20)Background: Tanzania currently rolls out vaccination against rotavirus-diarrhea, a major cause of child illness and death. As the vaccine covers a limited number of rotavirus variants, this study describes the molecular ... -
Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical giardia lamblia assemblage A and B isolates
Saghaug, Christina Skår; Klotz, Christian; Kallio, Juha Pekka; Brattbakk, Hans-Richard; Stokowy, Tomasz; Aebischer, Toni; Kursula, Inari; Langeland, Nina; Hanevik, Kurt (Peer reviewed; Journal article, 2019-05-10)Purpose: Treatment-refractory Giardia cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established yet, but several enzymes and their pathways ... -
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
Hanevik, Kurt; Kristoffersen, Einar; Mørch, Kristine; Rye, Kristin Paulsen; Sørnes, Steinar; Svärd, Staffan; Bruserud, Øystein; Langeland, Nina (Peer reviewed; Journal article, 2017-01-28)Background: The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. ... -
Giardiasis treatment: an update with a focus on refractory disease
Mørch, Kristine; Hanevik, Kurt (Journal article; Peer reviewed, 2020-10)Purpose of review Giardiasis remains a common cause of diarrhea and intestinal enteropathy globally. Here we give an overview of clinical treatment studies and discuss potential mechanisms and molecular targets for ... -
Human mucosal IgA immune responses against enterotoxigenic escherichia coli
Riaz, Saman; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2020-08-29)Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ... -
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome
Hanevik, Kurt; Kristoffersen, Einar K.; Sørnes, Steinar; Mørch, Kristine; Næss, Halvor; Rivenes, Ann Christin; Bødtker, Jørn; Hausken, Trygve; Langeland, Nina (Peer reviewed; Journal article, 2012-10-14)Background: A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting ... -
Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
Rajilic-Stojanovic, Mirjana; Jonkers, Daisy M; Salonen, Anne; Hanevik, Kurt; Raes, Jeroen; Jalanka, Jonna; de Vos, Willem M; Manichanh, Chaysavanh; Golic, Natasa; Enck, Paul; Elena, Philippou; Iraqi, Fuad A; Clarke, Gerard; Spiller, Robin C; Penders, John (Peer reviewed; Journal article, 2015-01-27)Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, ... -
Irritable Bowel Syndrome and Chronic Fatigue 6 Years After Giardia Infection: A Controlled Prospective Cohort Study
Hanevik, Kurt; Wensaas, Knut-Arne; Rørtveit, Guri; Eide, Geir Egil; Mørch, Kristine; Langeland, Nina (Peer reviewed; Journal article, 2014-08-12)Background. Functional gastrointestinal disorders and fatigue may follow acute infections. This study aimed to estimate the persistence, prevalence, and risk of irritable bowel syndrome and chronic fatigue 6 years after ... -
Monocytes from neonates and adults have a similar capacity to adapt their cytokine production after previous exposure to BCG and β-glucan
Namakula, Rhoda; de Bree, L Charlotte J; Tvedt, Tor Henrik Anderson; Netea, Mihai G; Cose, Stephen; Hanevik, Kurt (Journal article; Peer reviewed, 2020-02-21)The Bacillus Calmette-Guérin (BCG) vaccine is administered at birth in tuberculosis (TB) endemic countries. BCG vaccination is also associated with protective non-specific effects against non-tuberculous infections. This ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Rykkje Heien, Astrid; Gjerde Tellevik, Marit; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
Haanshuus, Christel Gill; Mohn, Stein Christian; Mørch, Kristine; Langeland, Nina; Blomberg, Bjørn; Hanevik, Kurt (Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
Haanshuus, Christel Gill; Mohn, Stein Christian; Mørch, Kristine; Langeland, Nina; Blomberg, Bjørn; Hanevik, Kurt (Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
Perceived food intolerance and irritable bowel syndrome in a population 3 years after a giardiasis-outbreak: a historical cohort study
Litleskare, Sverre; Wensaas, Knut-Arne; Eide, Geir Egil; Hanevik, Kurt; Kahrs, Gudrun E; Langeland, Nina; Rørtveit, Guri (Peer reviewed; Journal article, 2015-11-19)Background: Studies have shown an increased prevalence of irritable bowel syndrome (IBS) after acute gastroenteritis. Food as a precipitating and perpetuating factor in IBS has gained recent interest, but food intolerance ... -
Performance and operational feasibility of two diagnostic tests for cryptosporidiosis in children (CRYPTO-POC): a clinical, prospective, diagnostic accuracy study
Johansen, Øystein Haarklau; Abdissa, Alemseged; Zangenberg, Mike; Mekonnen, Zeleke; Eshetu, Beza; Bjørang, Ola; Alemu, Yonas; Sharew, Bizuwarek; Langeland, Nina; Robertson, Lucy; Hanevik, Kurt (Journal article; Peer reviewed, 2020)Background: Cryptosporidiosis is a common cause of diarrhoea in young children (aged younger than 24 months) in low-resource settings but is currently challenging to diagnose. Light-emitting diode fluorescence microscopy ... -
Plasma levels of guanylins are reduced in patients with Crohn’s disease
Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Tronstad, Rune Rose; Dizdar, Vernesa; Nylund, Kim; Hanevik, Kurt; Hausken, Trygve; Gilja, Odd Helge; Fiskerstrand, Torunn (Journal article; Peer reviewed, 2020)Background: Guanylin (GN) and uroguanylin (UGN) are endogenous ligands for the intestinal receptor guanylate cyclase C (GC-C), an important regulator of intestinal fluid homeostasis. Gene expression and protein levels of ...