Browsing Bergen Open Research Archive by Author "Hansmann, Jan"
Now showing items 1-5 of 5
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Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor
Yamada, Shuntaro; Yassin, Mohammed Ahmed; Schwarz, Thomas; Hansmann, Jan; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)The fatal determination of bone marrow mesenchymal stem/stromal cells (BMSC) is closely associated with mechano-environmental factors in addition to biochemical clues. The aim of this study was to induce osteogenesis in ... -
Optimisation and validation of a custom-designed perfusion bioreactor for bone tissue engineering: Flow assessment and optimal culture environmental conditions
Yamada, Shuntaro; Yassin, Mohammed Ahmed Alamin Yousif; Schwarz, Thomas; Mustafa, Kamal Babikeir Elnour; Hansmann, Jan (Journal article; Peer reviewed, 2022)Various perfusion bioreactor systems have been designed to improve cell culture with three-dimensional porous scaffolds, and there is some evidence that fluid force improves the osteogenic commitment of the progenitors. ... -
Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three- dimensional microporous scaffolds
Yamada, Shuntaro; Yassin, Mohammed Ahmed; Weigel, Tobias; Schmitz, Tobias; Hansmann, Jan; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2021)Various types of synthetic polyesters have been developed as biomaterials for tissue engineering. These materials commonly possess biodegradability, biocompatibility, and formability, which are preferable properties for ... -
Translation of Biophysical Environment in Bone into Dynamic Cell Culture under Flow for Bone Tissue Engineering
Yamada, Shuntaro; Niklas Ockermann, Philipp; Schwarz, Thomas; Mustafa, Kamal Babikeir Elnour; Hansmann, Jan (Journal article; Peer reviewed, 2023)Bone is a dynamic environment where osteocytes, osteoblasts, and mesenchymal stem/progenitor cells perceive mechanical cues and regulate bone metabolism accordingly. In particular, interstitial fluid flow in bone and bone ... -
Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho-ROCK-mediated contractility dependent
Yamada, Shuntaro; Yassin, Mohammed Ahmed; Torelli, Francesco; Hansmann, Jan; Green, Jeremy; Mustafa, Kamal (Journal article; Peer reviewed, 2023)The fate determination of bone marrow mesenchymal stem/stromal cells (BMSC) is tightly regulated by mechanical cues, including fluid shear stress. Knowledge of mechanobiology in 2D culture has allowed researchers in bone ...