Browsing Bergen Open Research Archive by Author "Haslene-Hox, Hanne"
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The microenvironment in human ovarian carcinoma - characterization through proteomic analysis of tissue interstitial fluid
Haslene-Hox, Hanne (Doctoral thesis, 2013-10-11)The interstitial fluid of tissues and that of tumors in particular, represents the secretome and is thus a valuable source of tissue-specific proteins. The differential expression of proteins that are secreted in tumor ... -
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats
Thowsen, Irene Matre; Karlsen, Tine Veronica; Nikpey, Elham; Haslene-Hox, Hanne; Skogstrand, Trude; Randolph, Gwendalyn J.; Zinselmeyer, Bernd H.; Tenstad, Olav; Wiig, Helge (Journal article; Peer reviewed, 2022)Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated whether there were electrolyte gradients ... -
A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue
Haslene-Hox, Hanne; Oveland, Eystein; Berg, Kaja Christine Graue; Kolmannskog, Odd; Woie, Kathrine; Salvesen, Helga Birgitte; Tenstad, Olav; Wiig, Helge (Peer reviewed; Journal article, 2011-04-26)Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ... -
Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood
Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga Birgitte; Wiig, Helge; Tenstad, Olav (Peer reviewed; Journal article, 2014-12)Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ...