• Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients 

      Watne, Leiv Otto; Pollmann, Christian Thomas; Neerland, Bjørn Erik; Quist-Paulsen, Else; Halaas, Nathalie Bodd; Idland, Ane-Victoria; Hassel, Bjørnar; Henjum, Kristi; Knapskog, Anne Brita; Frihagen, Frede; Ræder, Johan; Godø, Aasmund; Ueland, Per Magne; McCann, Adrian; Figved, Paul Wender; Selbæk, Geir; Zetterberg, Henrik; Fei Fang, Evandro; Myrstad, Marius; Giil, Lasse Melvær (Journal article; Peer reviewed, 2022)
      Background: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) ...
    • Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity 

      Watne, Leiv Otto; Idland, Ane-Victoria; Fekkes, Durk; Ræder, Johan; Frihagen, Frede Jon; Ranhoff, Anette Hylen; Chaudhry, Farrukh Abbas; Engedal, Knut; Wyller, Torgeir Bruun; Hassel, Bjørnar (Peer reviewed; Journal article, 2016-08-02)
      Background: To examine whether delirium in hip fracture patients was associated with changes in the levels of amino acids and/or monoamine metabolites in cerebrospinal fluid (CSF) and serum. Methods: In this prospective ...
    • β-Amyloid may accumulate in the human brain after focal bacterial infection: a 18F-flutemetamol positron emission tomography study 

      Rogne, Ane Gretesdatter; Müller, Ebba Gløersen; Udnæs, Eirin; Sigurdardottir, Solrun; Raudeberg, Rune; Connelly, James Pattrick; Revheim, Mona-Elisabeth; Hassel, Bjørnar; Dahlberg, Daniel (Journal article; Peer reviewed, 2021)
      Background and purpose β‐Amyloid formation has been suggested to form part of the brain's response to bacterial infection. This hypothesis has been based on experimental animal studies and autopsy studies in humans. We ...