Blar i Bergen Open Research Archive på forfatter "Hatlebakk, Jan Gunnar"
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Acute effect of a cod protein hydrolysate on postprandial acylated ghrelin concentration and sensations associated with appetite in healthy subjects: a double-blind crossover trial
Dale, Hanna Fjeldheim; Jensen, Caroline; Hausken, Trygve; Lied, Einar; Hatlebakk, Jan Gunnar; Brønstad, Ingeborg; Hoff, Dag Arne Lihaug; Lied, Gülen Arslan (Peer reviewed; Journal article, 2019-10-22)Background: Fish protein hydrolysates are suggested to contain bioactive sequences capable of affecting metabolic pathways involved in the regulation of glucose metabolism and body weight when consumed in low doses. ... -
Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome
El-Salhy, Magdy; Valeur, Jørgen; Hausken, Trygve; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2020)Background Short‐chain fatty acids (SCFAs) may play a role in the pathophysiology of irritable bowel syndrome (IBS). This study analyzed fecal SCFAs after performing fecal microbiota transplantation (FMT) in the IBS ... -
Changes in the symptom pattern and the densities of large-intestinal endocrine cells following Campylobacter infection in irritable bowel syndrome: a case report
El-Salhy, Magdy; Mazzawi, Tarek; Gundersen, Doris; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2013-09-29)Background Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder. Post-infectious IBS (PI-IBS) is a subset of IBS that accounts for a large proportion of IBS patients. The PI-IBS symptoms ... -
Chromogranin A Cell Density as a Diagnostic Marker for Lymphocytic Colitis
El-Salhy, Magdy; Gundersen, Doris; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2012-06-15)Background: Lymphocytic colitis (LC) can be mistakenly diagnosed as irritable bowel syndrome (IBS). In a previous study on IBS, some patients showed extremely high colonic chromogranin A cell density. Further examination ... -
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels
Mazzawi, Tarek; Hausken, Trygve; Hov, Johannes Espolin Roksund; Valeur, Jørgen; Sangnes, Dag André; El-Salhy, Magdy; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Lied, Gülen Arslan (Peer reviewed; Journal article, 2019)Objectives: Irritable bowel syndrome (IBS) may be associated with disturbances in gut microbiota composition and functions. We recently performed a study of fecal microbiota transplantation (FMT) in diarrhea-predominant ... -
Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome
El-Salhy, Magdy; Hausken, Trygve; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2020)Irritable bowel syndrome (IBS) affects ~12% of the global population. Although the etiology of IBS is not completely understood, several factors are known to serve a pivotal role in its pathophysiology, including genetic ... -
Diet in Irritable Bowel Syndrome (IBS): Interaction with Gut Microbiota and Gut Hormones
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2019-08-07)Diet plays an important role not only in the pathophysiology of irritable bowel syndrome (IBS), but also as a tool that improves symptoms and quality of life. The effects of diet seem to be a result of an interaction with ... -
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial
Dale, Hanna Fjeldheim; Jensen, Caroline; Hausken, Trygve; Lied, Einar; Hatlebakk, Jan Gunnar; Brønstad, Ingeborg; Hoff, Dag Arne Lihaug; Lied, Gülen Arslan (Peer reviewed; Journal article, 2018)The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these ... -
The effect of supplementation with low doses of a cod protein hydrolysate on satiety hormones and inflammatory biomarkers in adults with metabolic syndrome: A randomized, double-blind study
Jensen, Caroline; Dale, Hanna Fjeldheim; Hausken, Trygve; Hatlebakk, Jan Gunnar; Brønstad, Ingeborg; Lied, Gülen Arslan; Hoff, Dag Arne Lihaug (Journal article; Peer reviewed, 2020-11)Metabolic syndrome (MetS) is characterised by metabolic abnormalities that increase the risk of developing type 2 diabetes mellitus and cardiovascular disease. Altered levels of circulating ghrelin, several adipokines and ... -
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Gilja, Odd Helge; Bråthen Kristoffersen, Anja; Hausken, Trygve (Peer reviewed; Journal article, 2020)Objective: Faecal microbiota transplantation (FMT) from healthy donors to patients with irritable bowel syndrome (IBS) has been attempted in two previous double-blind, placebo-controlled studies. While one of those studies ... -
Gastric emptying of low- and high-caloric liquid meals measured using ultrasonography in healthy volunteers
Mazzawi, Tarek; Bartsch, Emily; Benammi, Sara; Ferro, Rosa Maria Carrasco; Nikitina, Ekaterina; Nimer, Nancy; Ortega, Lara Jiménez; Perrotte, Charles; Pithon, Joäo Vitor; Rosalina, Safira; Sharp, Alexis; Stevano, Reza; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2019-01-07)Purpose Delayed gastric emptying is present in patients with functional dyspepsia (FD), diabetes mellitus, and neurological diseases. Diet may affect gastric emptying symptoms in patients with FD. We sought to determine ... -
Increasing the Dose and/or Repeating Faecal Microbiota Transplantation (FMT) Increases the Response in Patients with Irritable Bowel Syndrome (IBS)
El-Salhy, Magdy; Hausken, Trygve; Hatlebakk, Jan Gunnar (Peer reviewed; Journal article, 2019-06-24)Background: Faecal microbiome transplantation (FMT) appears to be an effective method for treating irritable bowel syndrome (IBS) patients. However, it is not clear if a high transplant dose and/or repeating FMT are/is ... -
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
Mazzawi, Tarek; Lied, Gülen Arslan; Sangnes, Dag André; El-Salhy, Magdy; Hov, Johannes Espolin Roksund; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2018-11-14)Background: Gut microbiota alterations are important in irritable bowel syndrome (IBS). The aim was to investigate the effect of fecal microbiota transplantation (FMT) on gut microbiota and the symptoms in patients with ... -
Low Densities of Serotonin and Peptide YY Cells in the Colon of Patients with Irritable Bowel Syndrome
El-Salhy, Magdy; Gundersen, Doris; Østgaard, Hege; Lomholt-Beck, B.; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2011-11-05)Background The gut hormones are important in regulating gastrointestinal motility. Disturbances in gastrointestinal motility have been reported in patients with irritable bowel syndrome (IBS). Reduced endocrine cell density, ... -
Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy-resistant achalasia
Pham, Khanh Do-Cong; Havre, Roald Flesland; Langø, Thomas; Hofstad, Erlend Fagertun; Tangen, Geir Arne; Mårvik, Ronald; Pham, T.; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Viste, Asgaut (Peer reviewed; Journal article, 2018-04)Background In achalasia, muscle spasm may involve the proximal esophagus. When the muscle spasm is located in the proximal esophagus, conventional per oral endoscopic myotomy (POEM) may not be sufficient to relieve symptoms. ... -
Overlapping of irritable bowel syndrome with erosive esophagitis and the performance of Rome criteria in diagnosing IBS in a clinical setting
El-Salhy, Magdy; Gilja, Odd Helge; Hatlebakk, Jan Gunnar (Peer reviewed; Journal article, 2019)Irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD) overlap. It is not clear whether GERD is caused by non‑erosive esophagitis, or erosive esophagitis. The Rome criteria are not widely used for the ... -
Pathophysiology of idiopathic gastroparesis and implications for therapy
Bekkelund, Mattis; Sangnes, Dag André; Hatlebakk, Jan Gunnar; Aabakken, Lars (Peer reviewed; Journal article, 2019)Objectives: Idiopathic gastroparesis is a gastric motility disorder characterized by chronic upper gastrointestinal symptoms and delayed gastric emptying without an identifiable underlying condition. This review summarizes ... -
Possible role of peptide YY (PYY) in the pathophysiology of irritable bowel syndrome (IBS)
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2020)Irritable bowel syndrome (IBS) is a common gastrointestinal disorder of unknown aetiology for which there is no effective treatment. Although IBS does not increase mortality, it reduces the quality of life and is an economic ... -
The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Gilja, Odd Helge; Hausken, Trygve (Peer reviewed; Journal article, 2015-09-07)Wheat products make a substantial contribution to the dietary intake of many people worldwide. Despite the many beneficial aspects of consuming wheat products, it is also responsible for several diseases such as celiac ... -
Study protocol of the Bergen brain-gut-microbiota-axis study: A prospective case-report characterization and dietary intervention study to evaluate the effects of microbiota alterations on cognition and anatomical and functional brain connectivity in patients with irritable bowel syndrome
Berentsen, Birgitte; Nagaraja, Bharath Halandur; Teige, Erica Persson; Lied, Gülen Arslan; Lundervold, Astri; Lundervold, Katarina; Steinsvik, Elisabeth Kjelsvik; Hillestad, Eline Margrete Randulff; Valeur, Jørgen; Brønstad, Ingeborg; Gilja, Odd Helge; Osnes, Berge; Hatlebakk, Jan Gunnar; Haász, Judit; Labus, Jennifer; Gupta, Arpana; Mayer, Emeran; Benitez-Páez, Alfonso; Sanz, Yolanda; Lundervold, Arvid; Hausken, Trygve (Journal article; Peer reviewed, 2020-09)Introduction: Irritable bowel syndrome (IBS) is a common clinical label for medically unexplained gastrointestinal (GI) symptoms, recently described as a disturbance of the brain-gut-microbiota (BGM) axis. To gain a ...