• CDR2 antigen and Yo antibodies 

      Totland, Cecilie; Aarskog, Nina K.; Eichler, Tilo W.; Haugen, Mette; Nøstbakken, Jane K.; Monstad, Sissel E.; Salvesen, Helga Birgitte; Mørk, Sverre; Haukanes, Bjørn Ivar; Vedeler, Christian A. (Peer reviewed; Journal article, 2011)
      Paraneoplastic cerebellar degeneration (PCD) is often associated with Yo antibodies that are directed against human cerebellar degeneration-related protein 2 (CDR2). Such antibodies may also be found in ovarian cancer ...
    • CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration 

      Kråkenes, Torbjørn; Herdlevær, Ida Ajvazi; Raspotnig, Margrethe; Haugen, Mette; Schubert, Manja; Vedeler, Christian A. (Peer reviewed; Journal article, 2019)
      The pathogenesis of Yo‐mediated paraneoplastic cerebellar degeneration (PCD) is unclear. We applied cerebrospinal fluid and serum from PCD patients as well as CDR2 and CDR2L antibodies to neuronal tissue, cancer cell lines, ...
    • Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis 

      Schubert, Manja; Panja, Debabrata; Haugen, Mette; Bramham, Clive R.; Vedeler, Christian A. (Peer reviewed; Journal article, 2014-12)
      Paraneoplastic cerebellar degeneration (PCD) is characterized by loss of Purkinje cells (PCs) associated with progressive pancerebellar dysfunction in the presence of onconeural Yo antibodies. These antibodies recognize ...
    • Progressive striatal necrosis associated with anti-NMDA receptor antibodies 

      Tzoulis, Charalampos; Vedeler, Christian A.; Haugen, Mette; Storstein, Anette; Tran, Gia Tuong Thi; Gjerde, Ivar Otto; Biermann, Martin; Schwarzlmüller, Thomas; Bindoff, Laurence (Peer reviewed; Journal article, 2013-05-31)
      Background: We report a case of childhood onset, generalized dystonia due to slowly progressive bilateral striatal necrosis associated with anti-N-methyl-D-aspartate receptor (NMDAR) antibodies. This clinical phenotype has ...