Browsing Bergen Open Research Archive by Author "Haukaas, Svein Andreas"
Now showing items 1-5 of 5
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The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Mannelqvist, Monica; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2021)The prognostic importance of transcription factors promoting epithelial–mesenchymal transition (EMT) and angiogenesis has not been well explored in prostate cancer patients with long follow-up, nor the interplay between ... -
FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Beisland, Christian; Akslen, Lars A.; Halvorsen, Ole Johan (Peer reviewed; Journal article, 2019)Epithelial–mesenchymal transition (EMT) is important for tumour cell invasion and metastasis and is a feature of aggressive carcinomas. EMT is characterised by reduced E‐cadherin and increased N‐cadherin expression ... -
Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer
Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ... -
The prognostic relevance of interactions between venous invasion, lymph node involvement and distant metastases in renal cell carcinoma after radical nephrectomy
Zubac, Dragomir; Bostad, Leif; Seidal, Tomas; Wentzel-Larsen, Tore; Haukaas, Svein Andreas (Peer reviewed; Journal article, 2008-12-19)Background: To investigate a possible prognostic significance of interactions between lymph node invasion (LNI), synchronous distant metastases (SDM), and venous invasion (VI) adjusted for mode of detection, Eastern ... -
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression
Sui, Lufei; Wang, Suming; Ganguly, Debolina; El Rayes, Tyler P.; Askeland, Cecilie; Børretzen, Astrid; Sim, Danielle; Halvorsen, Ole Johan; Knutsvik, Gøril; Arnes, Jarle; Aziz, Sura Mohammed; Haukaas, Svein Andreas; Foulkes, William D.; Bielenberg, Diane R.; Ziemys, Arturas; Mittal, Vivek; Brekken, Rolf A.; Akslen, Lars Andreas; Watnick, Randolph (Journal article; Peer reviewed, 2022)The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ...