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Browsing Bergen Open Research Archive by Author "Hegvik, Tor-Arne"

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    • Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study 

      Hegvik, Tor-Arne; Instanes, Johanne Telnes; Haavik, Jan; Klungsøyr, Kari; Engeland, Anders (Peer reviewed; Journal article, 2018-05)
      Several studies have demonstrated associations between neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD), and the immune system, including autoimmune diseases. Since ADHD and many autoimmune ...
    • A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study 

      Hegvik, Tor-Arne; Jacobsen, Kaya Kvarme; Fredriksen, Mats; Zayats, Tetyana; Haavik, Jan (Peer reviewed; Journal article, 2016-08)
      Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence of ADHD symptoms into adulthood is common. Methylphenidate ...
    • Common psychiatric and metabolic comorbidity of adult attention-deficit/hyperactivity disorder: A population-based cross-sectional study 

      Chen, Qi; Hartman, Catharina A; Haavik, Jan; Harro, Jaanus; Klungsøyr, Kari; Hegvik, Tor-Arne; Wanders, Rob; Ottosen, Cæcilie; Dalsgaard, Søren; Faraone, Stephen V.; Larsson, Henrik (Peer reviewed; Journal article, 2018-09-26)
      Attention-deficit/hyperactivity disorder (ADHD) is often comorbid with other psychiatric conditions in adults. Yet, less is known about its relationship with common metabolic disorders and how sex and ageing affect the ...
    • Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment. 

      Hegvik, Tor-Arne; Waløen, Kai; Pandey, Sunil Kumar; Faraone, Stephen V.; Haavik, Jan; Zayats, Tetyana (Peer reviewed; Journal article, 2019)
      Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder with only symptomatic care available. Genome-wide association (GWA) studies can provide a starting point in the search for novel drug ...
    • GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production 

      Mahootchi, Elaheh; Homaei, Selina Cannon; Kleppe, Rune; Winge, Ingeborg; Hegvik, Tor-Arne; Perez, Roberto Megias; Totland, Christian; Mogavero, Floriana; Baumann, Anne; Glennon, Jeffrey Colm; Miletic, Hrvoje; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2020)
      Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neuromodulators. However, their biosynthetic routes and therapeutic potential are still being debated. This ...
    • Paraneoplastic syndrome-associated neuronal antibodies in adult ADHD 

      Haukanes, Bjørn Ivar; Hegvik, Tor-Arne; Eichler, Tilo Wolf; Haavik, Jan; Vedeler, Christian A. (Peer reviewed; Journal article, 2015-09-01)
      A high seroprevalence of Yo antibodies targeting cerebellar Purkinje cells was recently reported in children with attention deficit/hyperactivity disorder (ADHD). We investigated the presence of 8 paraneoplastic neurological ...
    • Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study 

      Hegvik, Tor-Arne; Ulvik, Arve; Halmøy, Anne; Haavik, Jan; Aarsland, Tore Ivar Malmei; Landaas, Elisabeth Toverud; Ueland, Per Magne (Peer reviewed; Journal article, 2015-11-05)
      Background: The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several ...

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