Browsing Bergen Open Research Archive by Author "Helgeland, Erik"
Now showing items 1-4 of 4
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B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion
Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Peer reviewed; Journal article, 2015-04)Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ... -
Exploring the human plasma proteome for humoral mediators of remote ischemic preconditioning - A word of caution
Helgeland, Erik; Breivik, Lars Ertesvåg; Vaudel, Marc; Svendsen, Øyvind Sverre; Garberg, Hilde Kristin; Nordrehaug, Jan Erik; Berven, Frode S.; Jonassen, Anne Kristin (Peer reviewed; Journal article, 2014-10-15)Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ... -
Insulin and GSK3β-inhibition abrogates the infarct sparing-effect of ischemic postconditioning in ex vivo rat hearts
Helgeland, Erik; Wergeland, Anita; Sandøy, Rune Kringstad; Askeland, Maren Haave; Aspevik, Anne; Breivik, Lars Ertesvåg; Jonassen, Anne K (Peer reviewed; Journal article, 2017)Objectives. Pharmacological treatment of reperfusion injury using insulin and GSK3β inhibition has been shown to be cardioprotective, however, their interaction with the endogenous cardioprotective strategy, ischemic ... -
Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion
Breivik, Lars Ertesvåg; Helgeland, Erik; Aarnes, Eva-Katrine; Mrdalj, Jelena; Jonassen, Anne Kristin (Peer reviewed; Journal article, 2010-12-29)Short non-lethal ischemic episodes administered to hearts prior to (ischemic preconditioning, IPC) or directly after (ischemic postconditioning, IPost) ischemic events facilitate myocardial protection. Transferring coronary ...