• Anabaenolysins, Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteria 

      Jokela, Jouni; Oftedal, Linn; Herfindal, Lars; Permi, Perttu; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Peer reviewed; Journal article, 2012-07-19)
      Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a ...
    • Anticancer activity in Planctomycetes 

      Calisto, Rita; Sæbø, Eirik Færøy; Storesund, Julia Endresen; Øvreås, Lise; Herfindal, Lars; Lage, Olga M. (Peer reviewed; Journal article, 2019-01-07)
      There is a strong need to develop new drugs against many severe diseases. Therapy resistance is a major problem, for instance, in infectious diseases and cancer. Drug discovery has again turned to nature to search for ...
    • The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity 

      Oftedal, Linn; Skjærven, Kaja H.; Coyne, Rosie T.; Edvardsen, Bente; Rohrlack, Thomas; Skulberg, Olav M.; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2010-08-06)
      Cyanobacteria (83 strains and seven natural populations) were screened for content of apoptosis (cell death)-inducing activity towards neoplastic cells of the immune (jurkat acute T-cell lymphoma) and hematopoetic (acute ...
    • AXL is a driver of stemness in normal mammary gland and breast cancer 

      Engelsen, Agnete; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien; Vatter, Fanny A. Pelissier; Tiron, Crina Elena; Villadsen, René; Miyano, Masaru; Lotsberg, Maria Lie; Madeleine, Noëlly; Panahandeh, Pouda; Dhakal, Sushil; Tan, Tuan Zea; Peters, Stacey D'Mello; Grøndal, Sturla Magnus; Aziz, Sura Mohammed; Nord, Silje; Herfindal, Lars; Stampfer, Martha R.; Sørlie, Therese; Brekken, Rolf A; Straume, Oddbjørn; Halberg, Nils; Gausdal, Gro; Thiery, Jean Paul; Akslen, Lars A.; Petersen, Ole W.; LaBarge, Mark A.; Lorens, James (Journal article; Peer reviewed, 2020)
      The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ...
    • Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action 

      Kleppe, Rune; Herfindal, Lars; Døskeland, Stein Ove (Peer reviewed; Journal article, 2015-10-22)
      Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death. Their intracellular targets are the ...
    • Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes 

      Humisto, Anu; Jokela, Jouni; Teigen, Knut; Wahlsten, Matti; Permi, Perttu; Sivonen, Kaarina; Herfindal, Lars (Peer reviewed; Journal article, 2019-08-01)
      Hassallidins are cyclic glycolipopeptides produced by cyanobacteria and other prokaryotes. The hassallidin structure consists of a peptide ring of eight amino acids where a fatty acid chain, additional amino acids, and ...
    • Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells 

      Liu, Liwei; Herfindal, Lars; Jokela, Jouni; Shishido, Tania Keiko; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Peer reviewed; Journal article, 2014-04-03)
      In this study, we investigated forty cyanobacterial isolates from biofilms, gastropods, brackish water and symbiotic lichen habitats. Their aqueous and organic extracts were used to screen for apoptosis-inducing activity ...
    • Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis 

      Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frédéric; Rouhee, Nazanin; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Døskeland, Stein Ove (Peer reviewed; Journal article, 2013)
      We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect ...
    • Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L 

      Carpinteyro Diaz, Andrea Estefania; Herfindal, Lars; Rathe, Bendik Auran; Sletta, Kristine; Vedeler, Anni; Haavik, Svein; Fossen, Torgils (Peer reviewed; Journal article, 2019)
      For more than four centuries, the intake of Narthecium ossifragum has been associated with poisoning in domesticated animals. Saponins occurring in flowering tops of the plant are considered to cause kidney damage in calves. ...
    • Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles 

      Prandina, Anthony; Herfindal, Lars; Radix, S; Rongved, Pål; Doskeland, Stein Ove; Le Borgne, Marc; Perret, F (Journal article; Peer reviewed, 2018)
      Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. ...
    • Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression 

      Nygaard, Gyrid; Herfindal, Lars; Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Oveland, Eystein; Berven, Frode; Myhren, Lene Elisabeth; Høivik, Erling Andre; Lunde, Turid Helen Felli; Bakke, Marit; Døskeland, Stein Ove; Selheim, Frode (Peer reviewed; Journal article, 2017)
      Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ...
    • Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen 

      Herfindal, Lars; Myhren, Lene Elisabeth; Gjertsen, Bjørn Tore; Døskeland, Stein Ove; Gausdal, Gro (Peer reviewed; Journal article, 2013-07-11)
      Background: The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline ...
    • Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3 

      Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Døskeland, Stein Ove (Peer reviewed; Journal article, 2014-04-16)
      Analogs of the cyclic nucleotides cAMP and cGMP have been extensively used to mimic or modulate cellular events mediated by protein kinase A (PKA), Exchange protein directly activated by cAMP (Epac), or protein kinase G ...
    • Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells 

      Myhren, Lene Elisabeth; Nygård, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Døskeland, Stein Ove; Selheim, Frode; Herfindal, Lars (Peer reviewed; Journal article, 2013-01-30)
      Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ...
    • Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes 

      Oftedal, Linn Silje Wathne; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2010-10-14)
      The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial ...
    • Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity 

      Prestegard, Siv Kristin; Oftedal, Linn Silje Wathne; Coyne, Rosie Theresa; Nygård, Gyrid; Skjærven, Kaja Helvik; Knutsen, Gjert; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2009-11-18)
      In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in ...
    • Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy 

      Åsrud, Kathrine Sivertsen; Pedersen, Line; Aesoy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit (Peer reviewed; Journal article, 2019-09-24)
      The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ...
    • New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation 

      Solum, Eirik Johansson; Hansen, Trond Vidar; Aesoy, Reidun; Herfindal, Lars (Journal article; Peer reviewed, 2020)
      Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ...
    • NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform 

      Allahverdiyeva, Yagut; Aro, Eva-Mari; Bavel, Bert van; Escudero, Carlos; Funk, Christiane; Heinonen, Jarna; Herfindal, Lars; Lindblad, Peter; Makinen, Sari; Penttilä, Merja; Sivonen, Kaarina; Chauton, Matilde Skogen; Skomedal, Hanne; Skjermo, Jorunn (Journal article; Peer reviewed, 2021)
      NordAqua is a multidisciplinary Nordic Center of Excellence funded by NordForsk Bioeconomy program (2017–2022). The research center promotes Blue Bioeconomy and endeavours to reform the use of natural resources in a ...
    • A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae) 

      Ibrahim, Ayaan Hamdi Haji; Herfindal, Lars; Rathe, Bendik Auran; Andersen, Heidi Lie; Almeida, Jackson R. G. S.; Fossen, Torgils (Peer reviewed; Journal article, 2019)
      Neoglaziovia variegata is endemic to northeastern Brazil. The drought resistant plant produces edible fruits and is used as a fibre plant by rural communities in the Caatinga region where a variety of products are made ...