Browsing Bergen Open Research Archive by Author "Hermansen, Erland"
Now showing items 1-18 of 18
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Assessing the Anti-Inflammatory Effects of an Orally Dosed Enzymatically Liberated Fish Oil in a House Dust Model of Allergic Asthma
Currie, Crawford; Framroze, Bomi; Singh, Dave; Lea, Simon; Bjerknes, Christian; Hermansen, Erland (Journal article; Peer reviewed, 2022-10-14)Eosinophils are a major driver of inflammation in a number of human diseases, including asthma. Biologic therapies targeting IL-5 have enabled better control of severe eosinophilic asthma, but no such advances have been ... -
The association between preoperative MRI findings and clinical improvement in patients included in the NORDSTEN spinal stenosis trial
Aaen, Jørn Ståle; Banitalebi, Hasan; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Anvar, Masoud D; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Peer reviewed, 2022)Purpose To investigate potential associations between preoperative MRI findings and patient reported outcome measures (PROMs) after surgery for lumbar spinal stenosis (LSS). Methods The NORDSTEN trial included 437 ... -
Clinical and MRI findings in lumbar spinal stenosis: baseline data from the NORDSTEN study
Aaen, Jørn; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Banitalebi, Hasan; Anvar, Masoud; Brox, Jens Ivar; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Peer reviewed, 2021)Purpose: The aim was to describe magnetic resonance imaging findings in patients planned for lumbar spinal stenosis surgery. Further, to describe possible associations between MRI findings and patient characteristics with ... -
Clinical outcome after surgery for lumbarspinal stenosis in patients with insignificantlower extremity pain. A prospective cohortstudy from the Norwegian registry for spine surgery
Hermansen, Erland; Myklebust, Tor Åge; Austevoll, Ivar Magne; Rekeland, Frode; Solberg, Tore; Storheim, Kjersti; Grundnes, Oliver; Aaen, Jørn Ståle; Brox, Jens Ivar; Hellum, Christian; Indrekvam, Kari (Peer reviewed; Journal article, 2019-01-22)Background: Spinal stenosis is a clinical diagnosis in which the main symptom is pain radiating to the lower extremities, or neurogenic claudication. Radiological spinal stenosis is commonly observed in the population and ... -
Comparable Increases in Dural Sac Area After Three Different Posterior Decompression Techniques for Lumbar Spinal Stenosis: Radiological Results From a Randomized Controlled Trial in the NORDSTEN Study
Hermansen, Erland; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Aaen, Jørn Ståle; Banitalebi, Hasan; Anvar, Masoud; Rekeland, Frode; Brox, Jens Ivar; Franssen, Eric; Weber, Clemens; Solberg, Tore; Haug, Knut Jørgen; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari (Journal article; Peer reviewed, 2020)Purpose: To investigate changes in dural sac area after three different posterior decompression techniques in patients undergoing surgery for lumbar spinal stenosis. Decompression of the nerve roots is the main surgical ... -
Comparative effectiveness of microdecompression alone vs decompression plus instrumented fusion in lumbar degenerative spondylolisthesis
Austevoll, Ivar Magne; Gjestad, Rolf; Solberg, Tore; Storheim, Kjersti; Brox, Jens Ivar; Hermansen, Erland; Rekeland, Frode; Indrekvam, Kari; Hellum, Christian (Journal article; Peer reviewed, 2020)Importance Conflicting evidence and large practice variation are present in the surgical treatment of degenerative spondylolisthesis. More than 90% of surgical procedures in the United States include instrumented fusion ... -
Comparison of 3 Different Minimally Invasive Surgical Techniques for Lumbar Spinal Stenosis: A Randomized Clinical Trial
Hermansen, Erland; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Aaen, Jørn Ståle; Banitalebi, Hasan; Anvar, Masoud D; Rekeland, Frode; Brox, Jens Ivar; Franssen, Eric; Weber, Clemens; Solberg, Tore; Furunes, Håvard; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari (Journal article; Peer reviewed, 2022)Importance: Operations for lumbar spinal stenosis is the most often performed surgical procedure in the adult lumbar spine. This study reports the clinical outcome of the 3 most commonly used minimally invasive posterior ... -
Decompression alone versusdecompression with instrumental fusionthe NORDSTEN degenerativespondylolisthesis trial (NORDSTEN-DS); study protocol for a randomized controlled trial
Austevoll, Ivar Magne; Hermansen, Erland; Fagerland, Morten; Rekeland, Frode; Solberg, Tore; Storheim, Kjersti; Brox, Jens Ivar; Lønne, Greger; Indrekvam, Kari; Aaen, Jørn; Grundnes, Oliver; Hellum, Christian (Peer reviewed; Journal article, 2019-01-05)Background: Fusion in addition to decompression has become the standard treatment for lumbar spinal stenosis with degenerative spondylolisthesis (DS). The evidence for performing fusion among these patients is conflicting ... -
Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis
Austevoll, Ivar Magne; Hermansen, Erland; Fagerland, Morten Wang; Storheim, Kjersti; Brox, Jens Ivar; Solberg, Tore; Rekeland, Frode; Franssen, Eric; Weber, Clemens; Brisby, Helena; Grundnes, Oliver; Algaard, Knut; Bøker, Tordis; Banitalebi, Hasan; Indrekvam, Kari; Hellum, Christian (Journal article; Peer reviewed, 2021)BACKGROUND In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone is noninferior to decompression with instrumented fusion. METHODS We conducted an ... -
Follow-up score, change score or percentage change score for determining clinical important outcome following surgery? An observational study from the Norwegian registry for Spine surgery evaluating patient reported outcome measures in lumbar spinal stenosis and lumbar degenerative spondylolisthesis
Austevoll, Ivar Magne; Gjestad, Rolf; Grotle, Margreth; Solberg, Tore; Brox, Jens Ivar; Hermansen, Erland; Rekeland, Frode; Indrekvam, Kari; Storheim, Kjersti; Hellum, Christian (Peer reviewed; Journal article, 2019-01-18)Background: Assessment of outcomes for spinal surgeries is challenging, and an ideal measurement that reflects all aspects of importance for the patients does not exist. Oswestry Disability Index (ODI), EuroQol (EQ-5D) and ... -
Is the presence of foraminal stenosis associated with outcome in lumbar spinal stenosis patients treated with posterior microsurgical decompression
Aaen, Jørn Ståle; BANITALEBI, HASAN; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Anvar, Masoud D; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Peer reviewed, 2023)Background We aim to investigate associations between preoperative radiological findings of lumbar foraminal stenosis with clinical outcomes after posterior microsurgical decompression in patients with predominantly central ... -
The Norwegian degenerative spondylolisthesis and spinal stenosis (NORDSTEN) study: study overview, organization structure and study population
Indrekvam, Kari; Bånerud, Ingrid Fjeldheim; Hermansen, Erland; Austevoll, Ivar Magne; Rekeland, Frode Gurvin; Guddal, Maren Hjelle; Solberg, Tore; Brox, Jens Ivar; Hellum, Christian; Storheim, Kjersti (Journal article; Peer reviewed, 2023)Purpose To provide an overview of the The Norwegian Degenerative spondylolisthesis and spinal stenosis (NORDSTEN)-study and the organizational structure, and to evaluate the study population. Methods The NORDSTEN is ... -
A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study
Aaen, Jørn Ståle; Storheim, Kjersti; Negård, Anne; Myklebust, Tor Åge; Grotle, Margreth; Hellum, Christian; Espeland, Ansgar; Anvar, Masoud D; Indrekvam, Kari; Weber, Clemens; Brox, Jens Ivar; Brisby, Helena; Hermansen, Erland; Banitalebi, Hasan (Journal article; Peer reviewed, 2022)Background Fatty infiltration of the paraspinal muscles may play a role in pain and disability in lumbar spinal stenosis. We assessed the reliability and association with clinical symptoms of a method for assessing fatty ... -
Pharmacological evaluation of the effects of enzymatically liberated fish oil on eosinophilic inflammation in animal models
Currie, Crawford; Framroze, Bomi; Singh, Dave; Sharma, Deepali; Bjerknes, Christian; Hermansen, Erland (Journal article; Peer reviewed, 2022)The inappropriate activation of eosinophils is a well-recognized driver of various human inflammatory diseases including asthma, chronic rhinitis, and various gastrointestinal diseases, including eosinophilic esophagitis. ... -
Postoperative Dural Sac Cross-Sectional Area as an Association for Outcome After Surgery for Lumbar Spinal Stenosis: Clinical and Radiological Results From the NORDSTEN-Spinal Stenosis Trial
Hermansen, Erland; Myklebust, Tor Åge; Weber, Clemens; Brisby, Helena; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Aaen, Jørn Ståle; Banitalebi, Hasan; Brox, Jens Ivar; Grundnes, Oliver; Rekeland, Frode Gurvin; Solberg, Tore; Franssen, Eric; Indrekvam, Kari (Journal article; Peer reviewed, 2023)Study Design: Prospective cohort study. Objective: The aim was to investigate the association between postoperative dural sac cross-sectional area (DSCA) after decompressive surgery for lumbar spinal stenosis and clinical ... -
Reliability of preoperative MRI findings in patients with lumbar spinal stenosis
Banitalebi, Hasan; Espeland, Ansgar; Anvar, Masoud D; Hermansen, Erland; Hellum, Christian; Brox, Jens Ivar; Myklebust, Tor Åge; Indrekvam, Kari; Brisby, Helena; Weber, Clemens; Aaen, Jørn Ståle; Austevoll, Ivar Magne; Grundnes, Oliver; Negård, Anne (Journal article; Peer reviewed, 2022)Background Magnetic Resonance Imaging (MRI) is an important tool in preoperative evaluation of patients with lumbar spinal stenosis (LSS). Reported reliability of various MRI findings in LSS varies from fair to excellent. ... -
Salmon Protein Hydrolysate Potentiates the Growth Inhibitory Effect of Bicalutamide on Human Prostate Cancer Cell Lines LNCaP and PC3 by Modulating Iron Homeostasis
Bjerknes, Christian; Framroze, Bomi; Currie, Crawford; Pettersen, Caroline Hild; Axcrona, Karol; Hermansen, Erland (Journal article; Peer reviewed, 2022)Prostate cancer is a common cause of cancer death in men. In advanced stages of prostate cancer, androgen deprivation therapy (ADT) is initiated. Despite ADT, prostate cancers invariably progress to become androgen ... -
Study-protocol for a randomized controlled trial comparing clinical and radiological results after three different posterior decompression techniques for lumbar spinal stenosis: the Spinal Stenosis Trial (SST) (part of the NORDSTEN Study)
Hermansen, Erland; Austevoll, Ivar Magne; Romild, Ulla Kristina; Rekeland, Frode; Solberg, Tore; Storheim, Kjersti; Grundnes, Oliver; Aaen, Jørn; Brox, Jens Ivar; Hellum, Christian; Indrekvam, Kari (Peer reviewed; Journal article, 2017-03-21)Background: There are several posterior decompression techniques for lumbar spinal stenosis (LSS). There is a trend towards performing less invasive surgical procedures, but no multicentre randomized controlled trials have ...